Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells

scientific article

Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1258/EBM.2011.010367
P932PMC publication ID3508693
P698PubMed publication ID21427233
P5875ResearchGate publication ID50808298

P50authorJeffrey SchlomQ90227155
P2093author name stringClaudia Palena
Bruce Huang
Duane H Hamilton
Mary T Litzinger
Romaine I Fernando
P2860cites workThe Hallmarks of CancerQ221226
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Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancersQ24674085
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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisQ28131703
Correlation of Snail expression with histological grade and lymph node status in breast carcinomasQ28206944
The snail superfamily of zinc-finger transcription factorsQ28216843
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traitsQ28237197
Identification of selective inhibitors of cancer stem cells by high-throughput screeningQ28255115
The transcriptional repressor Snail promotes mammary tumor recurrenceQ28272823
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cellsQ28304564
Snail blocks the cell cycle and confers resistance to cell deathQ28572344
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformationQ28589469
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
Complex networks orchestrate epithelial-mesenchymal transitionsQ29547478
Metastasis: from dissemination to organ-specific colonizationQ29614295
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathwaysQ29615855
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasionQ29616467
Molecular requirements for epithelial-mesenchymal transition during tumor progressionQ29618960
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating featuresQ29620020
Immunosuppressive strategies that are mediated by tumor cellsQ29636247
Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early developmentQ30311953
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cellsQ33604855
Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancerQ33703387
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?Q33727178
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Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancerQ35007782
The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferationQ35788475
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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansionQ36042084
Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patientsQ36614440
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The role of epithelial-mesenchymal transition in cancer pathologyQ36845018
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HER-2/neu antigen loss and relapse of mammary carcinoma are actively induced by T cell-mediated anti-tumor immune responsesQ37066149
Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic targetQ37151287
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progressionQ37286365
The functioning antigens: beyond just as the immunological targetsQ37483795
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A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.Q38301815
TGFβ and EGF synergistically induce a more invasive phenotype of epithelial ovarian cancer cellsQ39653885
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transitionQ39689085
Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cellsQ39834964
Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulationQ39954485
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotypeQ40012189
Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells.Q40111238
The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy.Q40145050
Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2.Q40200816
Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell linesQ40252973
Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinomaQ40349219
Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibitionQ40360895
Up-regulation of TWIST in prostate cancer and its implication as a therapeutic targetQ40409031
Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transitionQ40446051
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressorsQ40680001
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathwaysQ40757186
Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4+ and CD8+ T cell responsesQ41234424
A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancerQ42522113
Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.Q42671796
Twist expression in patients with cervical cancer is associated with poor disease outcomeQ43624019
Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responsesQ44885246
Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancyQ46434108
Development and characterization of gemcitabine-resistant pancreatic tumor cells.Q46971449
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.Q53376881
The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers.Q53629087
Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma.Q54677737
Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patientsQ73330168
Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients [seecomments]Q73368658
A crucial function of PDGF in TGF-beta-mediated cancer progression of hepatocytesQ83139111
P433issue5
P921main subjectphenotypeQ104053
P304page(s)537-545
P577publication date2011-03-22
P1433published inExperimental Biology and MedicineQ15716535
P1476titleStrategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells
P478volume236

Reverse relations

cites work (P2860)
Q39148033A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells
Q35741566Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody
Q37273999An autocrine loop between TGF-β1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype
Q24324198Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer
Q31153211Comparative genomic analysis of primary and synchronous metastatic colorectal cancers
Q38067434Epithelial-mesenchymal transition in carcinomas of the female genital tract
Q33276468Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma
Q38555670Immune Targeting of Tumor Epithelial-Mesenchymal Transition via Brachyury-Based Vaccines.
Q33275963Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT.
Q44392303Radiosensitization of brain metastasis by targeting c-MET.
Q64246941TGF-β inducible epithelial-to-mesenchymal transition in renal cell carcinoma
Q39706171Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer
Q97645866The Roles of Embryonic Transcription Factor BRACHYURY in Tumorigenesis and Progression
Q36985133The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies
Q39371308Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells
Q34463393mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch

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