Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis

scientific article published on 22 February 2017

Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP43078
P932PMC publication ID5320536
P698PubMed publication ID28225038

P2093author name stringRony Seger
Shiri Procaccia
Merav Ordan
Sarit Bendetz-Nezer
Izel Cohen
P2860cites workNovel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumorsQ22000766
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Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinasesQ28248110
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A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signalQ43543397
Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase PathwayQ43783336
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Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinaseQ72068689
Activated MEK1 binds the nuclear MyoD transcriptional complex to repress transactivationQ74484718
Comparative effects of paclitaxel and rapamycin on smooth muscle migration and survival: role of AKT-dependent signalingQ83215010
Ras, PI(3)K and mTOR signalling controls tumour cell growthQ29614734
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1Q29617416
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RETRACTED: Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinasesQ30570532
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteinsQ33887662
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Mitogen-activated Protein Kinase Kinase 1 (MEK1) Stabilizes MyoD through Direct Phosphorylation at Tyrosine 156 During Myogenic DifferentiationQ34998206
FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and InvasionQ35024427
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Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cellsQ35165105
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The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functionsQ36360691
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradationQ36647913
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MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral toleranceQ36764687
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Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
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Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibitionQ39442875
Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factorQ39551502
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptakeQ39616081
Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell linesQ39819940
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancersQ39859169
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectcell migrationQ189092
phosphorylationQ242736
P304page(s)43078
P577publication date2017-02-22
P1433published inScientific ReportsQ2261792
P1476titleDirect binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis
P478volume7

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cites work (P2860)
Q50137602FoxO transcription factors in cancer metabolism
Q47235498Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway
Q98725861IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas
Q92463729Inactivation of FOXO1 induces T follicular cell polarization and involves angioimmunoblastic T cell lymphoma
Q58428561Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases
Q47389746MicroRNA-497 Accelerates Apoptosis While Inhibiting Proliferation, Migration, and Invasion through negative regulation of the MAPK/ERK signaling pathway via RAF-1.
Q64115578Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer
Q90171484PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer
Q91691853Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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