scholarly article | Q13442814 |
P2093 | author name string | Rony Seger | |
Shiri Procaccia | |||
Merav Ordan | |||
Sarit Bendetz-Nezer | |||
Izel Cohen | |||
P2860 | cites work | Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors | Q22000766 |
MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade | Q24311840 | ||
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer | Q24338724 | ||
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1 | Q24596134 | ||
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation | Q24616946 | ||
GSK-3: tricks of the trade for a multi-tasking kinase | Q24624069 | ||
The PI3K pathway as drug target in human cancer | Q24632283 | ||
Targeting the PI3K signaling pathway in cancer | Q24647554 | ||
AKT/PKB signaling: navigating downstream | Q24657857 | ||
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers | Q27851457 | ||
Phosphorylation and regulation of Raf by Akt (protein kinase B) | Q28138863 | ||
Negative regulation of the serine/threonine kinase B-Raf by Akt | Q28139252 | ||
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling | Q28144330 | ||
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation | Q28188974 | ||
Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases | Q28248110 | ||
Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases | Q28268392 | ||
The activation of phosphatidylinositol 3-kinase by Ras | Q28305326 | ||
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 | Q28570374 | ||
Real-time imaging of lymphogenic metastasis in orthotopic human breast cancer. | Q40243329 | ||
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance | Q40253550 | ||
Regulation of Raf-Akt Cross-talk | Q40727585 | ||
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis | Q40750080 | ||
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. | Q40915594 | ||
The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt. | Q41843247 | ||
Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase | Q42828607 | ||
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal | Q43543397 | ||
Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway | Q43783336 | ||
Identification and characterization of a general nuclear translocation signal in signaling proteins | Q46399783 | ||
PI3K signalling: the path to discovery and understanding | Q54527804 | ||
Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase | Q72068689 | ||
Activated MEK1 binds the nuclear MyoD transcriptional complex to repress transactivation | Q74484718 | ||
Comparative effects of paclitaxel and rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling | Q83215010 | ||
Ras, PI(3)K and mTOR signalling controls tumour cell growth | Q29614734 | ||
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K | Q29614757 | ||
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 | Q29617416 | ||
Targeting PI3K signalling in cancer: opportunities, challenges and limitations | Q29617685 | ||
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer | Q29618030 | ||
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer | Q29618155 | ||
Phosphatidylinositol-3-OH kinase as a direct target of Ras | Q29620177 | ||
RETRACTED: Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases | Q30570532 | ||
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins | Q33887662 | ||
Ten years of protein kinase B signalling: a hard Akt to follow | Q34432885 | ||
Tangled webs: evidence of cross-talk between c-Raf-1 and Akt. | Q34543737 | ||
Mitogen-activated Protein Kinase Kinase 1 (MEK1) Stabilizes MyoD through Direct Phosphorylation at Tyrosine 156 During Myogenic Differentiation | Q34998206 | ||
FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion | Q35024427 | ||
The many forks in FOXO's road | Q35079447 | ||
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells | Q35165105 | ||
Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma | Q35641787 | ||
Structure, regulation and function of PKB/AKT--a major therapeutic target | Q35692051 | ||
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions | Q36360691 | ||
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation | Q36647913 | ||
The MEK/ERK cascade: from signaling specificity to diverse functions | Q36656631 | ||
MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance | Q36764687 | ||
Intracellular signaling by Akt: bound to be specific | Q37193392 | ||
PI3K/Akt: getting it right matters | Q37310202 | ||
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition | Q37331610 | ||
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer | Q37376100 | ||
The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions | Q37784732 | ||
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation | Q37822076 | ||
PTEN loss in the continuum of common cancers, rare syndromes and mouse models. | Q37856722 | ||
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins | Q37894891 | ||
The ERK Cascade: Distinct Functions within Various Subcellular Organelles | Q37903694 | ||
MEK1/2 dual-specificity protein kinases: Structure and regulation | Q37969380 | ||
ERK1/2 MAP kinases: structure, function, and regulation | Q38008550 | ||
The nuclear translocation of ERK1/2 as an anticancer target. | Q38893704 | ||
Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition | Q39442875 | ||
Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor | Q39551502 | ||
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake | Q39616081 | ||
Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines | Q39819940 | ||
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers | Q39859169 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P4510 | describes a project that uses | ImageJ | Q1659584 |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell migration | Q189092 |
phosphorylation | Q242736 | ||
P304 | page(s) | 43078 | |
P577 | publication date | 2017-02-22 | |
P1433 | published in | Scientific Reports | Q2261792 |
P1476 | title | Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis | |
P478 | volume | 7 |
Q50137602 | FoxO transcription factors in cancer metabolism |
Q47235498 | Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway |
Q98725861 | IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas |
Q92463729 | Inactivation of FOXO1 induces T follicular cell polarization and involves angioimmunoblastic T cell lymphoma |
Q58428561 | Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases |
Q47389746 | MicroRNA-497 Accelerates Apoptosis While Inhibiting Proliferation, Migration, and Invasion through negative regulation of the MAPK/ERK signaling pathway via RAF-1. |
Q64115578 | Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer |
Q90171484 | PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer |
Q91691853 | Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks |
Search more.