| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NSMB.1564 |
| P698 | PubMed publication ID | 19219045 |
| P50 | author | Manuela Baccarini | Q21264306 |
| Federica Catalanotti | Q125215562 | ||
| Veronika Jesenberger | Q125344561 | ||
| Gergana Galabova-Kovacs | Q125344576 | ||
| P2093 | author name string | Oliviero Carugo | |
| Gloria Reyes | |||
| Ricardo de Matos Simoes | |||
| P2860 | cites work | Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites | Q24309323 |
| MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade | Q24311840 | ||
| Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway | Q24534940 | ||
| IQGAP1 is a scaffold for mitogen-activated protein kinase signaling | Q24535435 | ||
| Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome | Q46550924 | ||
| Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition | Q50335943 | ||
| IQPNNI: moving fast through tree space and stopping in time | Q51636617 | ||
| Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain | Q52099750 | ||
| Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia. | Q52578300 | ||
| BRAF and MEK mutations make a late entrance | Q82995707 | ||
| MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform | Q24540347 | ||
| ProbCons: Probabilistic consistency-based multiple sequence alignment | Q24557418 | ||
| MUSCLE: multiple sequence alignment with high accuracy and high throughput | Q24613456 | ||
| Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation | Q24614153 | ||
| M-Coffee: combining multiple sequence alignment methods with T-Coffee | Q25257876 | ||
| Mutations of the BRAF gene in human cancer | Q27860760 | ||
| Active Ras induces heterodimerization of cRaf and BRaf | Q28185999 | ||
| PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation | Q28188974 | ||
| Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization | Q28287759 | ||
| Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta | Q28511740 | ||
| Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation | Q28574106 | ||
| Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate | Q28576088 | ||
| Regulation and role of Raf-1/B-Raf heterodimerization | Q28580581 | ||
| Spatial and temporal patterns of ERK signaling during mouse embryogenesis | Q28594004 | ||
| The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo | Q28609067 | ||
| Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1) | Q28609139 | ||
| Mek2 is dispensable for mouse growth and development | Q28609344 | ||
| Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety | Q29615160 | ||
| Coordinating ERK/MAPK signalling through scaffolds and inhibitors | Q29618995 | ||
| The RAF proteins take centre stage | Q29620153 | ||
| Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. | Q30193042 | ||
| Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion | Q30312140 | ||
| Integrin signalling in directed cell migration. | Q30441276 | ||
| MEK1 activation by PAK: a novel mechanism | Q30441421 | ||
| Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy | Q33308740 | ||
| MAP kinases and cell migration | Q35889220 | ||
| Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells | Q36121178 | ||
| GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor | Q36222393 | ||
| Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development | Q36491749 | ||
| Ras nanoclusters: combining digital and analog signaling | Q37062789 | ||
| Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene | Q39645041 | ||
| Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. | Q40247976 | ||
| Regulation of Raf-1 by direct feedback phosphorylation. | Q40467820 | ||
| MEK1 and MEK2, different regulators of the G1/S transition. | Q40530177 | ||
| A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase. | Q41070272 | ||
| Raf-1 regulates Rho signaling and cell migration | Q41887999 | ||
| Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf | Q44679396 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 294-303 | |
| P577 | publication date | 2009-02-15 | |
| P1433 | published in | Nature Structural & Molecular Biology | Q1071739 |
| P1476 | title | A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal | |
| P478 | volume | 16 |
| Q38220879 | "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway |
| Q35826693 | A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling |
| Q42675375 | A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells. |
| Q54650268 | A novel MEK2/PI3Kδ pathway controls the expression of IL-1 receptor antagonist in IFN-β-activated human monocytes. |
| Q36339315 | Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics |
| Q50292948 | Activated MAPKs phosphorylate MAP2K1 |
| Q92642778 | Adaptive Responses as Mechanisms of Resistance to BRAF Inhibitors in Melanoma |
| Q54978059 | An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. |
| Q35547898 | Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation |
| Q37657919 | Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis |
| Q50292970 | Dissociation of p-T,Y-MAPK3:MAP2K1 |
| Q34768262 | ERK2 is essential for the growth of human epithelioid malignant mesotheliomas. |
| Q42005192 | Ectopic expression of the male BmDSX affects formation of the chitin plate in female Bombyx mori. |
| Q37588717 | Emerging Raf inhibitors. |
| Q37192616 | Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy |
| Q36938348 | Exploiting conformational ensembles in modeling protein-protein interactions on the proteome scale |
| Q34544759 | Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth |
| Q41909915 | From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity |
| Q33698374 | From basic research to clinical development of MEK1/2 inhibitors for cancer therapy |
| Q54219237 | Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect. |
| Q33565363 | Genome scale modeling in systems biology: algorithms and resources |
| Q41752617 | Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma. |
| Q36685109 | Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation |
| Q50292933 | MAP2Ks and MAPKs bind to the activated RAF complex |
| Q33916063 | MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening |
| Q64059604 | MAPK/ERK Signaling in Regulation of Renal Differentiation |
| Q36099005 | MEK genomics in development and disease |
| Q36041862 | MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1. |
| Q38092584 | MEK inhibitors as a chemotherapeutic intervention in multiple myeloma |
| Q38591835 | MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road |
| Q40698944 | MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages. |
| Q36764687 | MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance |
| Q37696978 | MEK1 is required for the development of NRAS-driven leukemia |
| Q91697812 | MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury |
| Q37969380 | MEK1/2 dual-specificity protein kinases: Structure and regulation |
| Q38086019 | Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount. |
| Q28484612 | Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression |
| Q39697330 | Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer |
| Q36862768 | Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response |
| Q45317149 | Negative feedback regulation of MAPK pathway |
| Q28079202 | Negative feedback regulation of the ERK1/2 MAPK pathway |
| Q45317147 | Negative regulation of MAPK pathway |
| Q24303902 | Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation |
| Q52666594 | New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling. |
| Q41667171 | Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates |
| Q37828536 | Novel mitogen-activated protein kinase kinase inhibitors |
| Q34552000 | Optical control of cell signaling by single-chain photoswitchable kinases |
| Q33890304 | Phylogenomic analysis of MKKs and MAPKs from 16 legumes and detection of interacting pairs in chickpea divulge MAPK signalling modules. |
| Q24316181 | Raf family kinases: old dogs have learned new tricks |
| Q28237793 | Raf kinases in cancer-roles and therapeutic opportunities |
| Q42562424 | Raf-independent, PP2A-dependent MEK activation in response to ERK silencing |
| Q37333782 | Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways. |
| Q33646519 | Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target |
| Q43095950 | Reconstruction of an Integrated Genome-Scale Co-Expression Network Reveals Key Modules Involved in Lung Adenocarcinoma |
| Q35783154 | Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain |
| Q30371492 | Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases |
| Q42728681 | Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression |
| Q88767177 | Role of MEK1 in TLR4 Mediated Signaling |
| Q34966603 | Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging |
| Q37865381 | Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. |
| Q41322187 | Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions |
| Q34711337 | Stress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineage |
| Q37301884 | Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging |
| Q37629722 | Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors |
| Q33823577 | Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells. |
| Q37903694 | The ERK Cascade: Distinct Functions within Various Subcellular Organelles |
| Q37784732 | The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions |
| Q52147605 | The Ras/Raf/Erk Pathway Mediates the Subarachnoid Hemorrhage-Induced Apoptosis of Hippocampal Neurons Through Phosphorylation of p53. |
| Q37626102 | The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma |
| Q37752795 | Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice |
| Q24315032 | Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction |
| Q54513771 | [Mek1 and Mek2 functions in the formation of the blood placental barrier]. |
| Q39554370 | c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma |
| Q38603219 | miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage. |
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