Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

scientific article published on 14 November 2004

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1017445972
P356DOI10.1038/NSMB859
P698PubMed publication ID15543157
P5875ResearchGate publication ID8184125

P2093author name stringPeter Kuffa
Alexander Pavlovsky
Iris K Leung
Jeffrey F Ohren
Patrick McConnell
Charles Omer
Huifen Chen
Erli Zhang
Chunhong Yan
Stephen Barrett
David T Dudley
Christopher Whitehead
Judith Sebolt-Leopold
Michael Kaufman
Amy Delaney
Cathlin Flamme
Charles A Hasemann
Cindy Spessard
Craig Banotai
Haile Tecle
Joseph Warmus
W Thomas Mueller
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Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathwayQ43691664
The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cellsQ47791722
2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitorQ47984433
Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP KinasesQ61640754
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1Q107343694
The protein kinase complement of the human genomeQ24324497
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Structural mechanism for STI-571 inhibition of abelson tyrosine kinaseQ27627097
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding siteQ27638349
Three-dimensional structure of the tyrosine kinase c-SrcQ27734749
Crystal structure of the Src family tyrosine kinase HckQ27734750
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
The CCP4 suite: programs for protein crystallographyQ27861090
Signaling by dual specificity kinasesQ28285928
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoQ28368373
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analogQ29616450
Crystal structure of cyclin-dependent kinase 2Q29622946
MOLREP: an Automated Program for Molecular ReplacementQ29642797
Mitogen-activated protein kinases: specific messages from ubiquitous messengersQ30303652
JOY: protein sequence-structure representation and analysis.Q30431389
Applications of anomalous scattering from S atoms for improved phasing of protein diffraction data collected at Cu Kalpha wavelengthQ30661021
Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352.Q31113651
Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological interventionQ34583868
Ras/Raf signalling and emerging pharmacotherapeutic targetsQ34660771
Designing bisubstrate analog inhibitors for protein kinasesQ34792879
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.Q37672900
Signal transduction through MAP kinase cascadesQ41750250
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.Q42435242
P433issue12
P304page(s)1192-1197
P577publication date2004-11-14
P1433published inNature Structural & Molecular BiologyQ1071739
P1476titleStructures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
P478volume11

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Q108120440Crystal structure of three solvated alphinumisoflavonesmain subjectP921