Novel mitogen-activated protein kinase kinase inhibitors

scientific article published on February 1, 2011

Novel mitogen-activated protein kinase kinase inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1517/13543784.2011.548803
P953full work available at URLhttp://www.informapharmascience.com/doi/abs/10.1517/13543784.2011.548803
http://www.tandfonline.com/doi/pdf/10.1517/13543784.2011.548803
P698PubMed publication ID21235429

P2093author name stringJeffrey N. Miner
Mark S. Chapman
P2860cites workEGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinibQ24561953
RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancerQ27657185
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthQ27659493
MEK1 mutations confer resistance to MEK and B-RAF inhibitionQ27777362
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancersQ27851426
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutationQ27851610
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Mutations of the BRAF gene in human cancerQ27860760
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumorsQ28297412
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoQ28368373
Cancer statistics, 2009Q29547625
BRAF mutation predicts sensitivity to MEK inhibitionQ29614281
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase KinaseQ29616448
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Ordered phosphorylation of p42mapk by MAP kinase kinaseQ30438677
Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenograftsQ33709656
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.Q34014364
A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancerQ34106382
Dysregulation of Met receptor tyrosine kinase activity in invasive tumorsQ34584046
MEK inhibitors: a therapeutic approach to targeting the Ras-MAP kinase pathway in tumorsQ35794067
Targeting the mitogen-activated protein kinase cascade to treat cancerQ35968411
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profilingQ36288956
Sorafenib: delivering a targeted drug to the right targetsQ36817095
Recent advances of MEK inhibitors and their clinical progressQ36907524
BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implicationsQ36972859
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinomaQ36980836
Ras and phosphoinositide 3-kinase: partners in development and tumorigenesisQ36997611
MAPKs and their relevance to arthritis and inflammationQ37054686
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.Q37109225
Oncogene addictionQ37152445
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
Recent developments in anti-cancer agents targeting the Ras/Raf/ MEK/ERK pathway.Q37370630
Targeting the RAF-MEK-ERK pathway in cancer therapyQ37393116
Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastasesQ37421620
Small molecules and targeted therapies in distant metastatic disease.Q37555793
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancerQ38445646
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical modelsQ39706127
E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MQ39812078
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.Q39830937
Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cellsQ39877518
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclQ40093939
Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoproteinQ40109392
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitorQ40164535
MEK1 and MEK2, different regulators of the G1/S transition.Q40530177
Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategiesQ42521987
PIKing the right patientQ43031144
Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.Q43244288
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signalQ43543397
Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignanciesQ46595207
The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxelQ46825496
Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppressionQ46868532
MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartmentsQ46956856
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibitionQ50335943
Oncogenes and tumor suppressor genes.Q53472800
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttargeted therapyQ492646
P304page(s)209-220
P577publication date2011-02-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titleNovel mitogen-activated protein kinase kinase inhibitors
P478volume20

Reverse relations

cites work (P2860)
Q36351612Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants.
Q35041937BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors
Q39365692Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic–Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor
Q26752774Cutaneous Side Effects of BRAF Inhibitors in Advanced Melanoma: Review of the Literature
Q38164679Dabrafenib therapy for advanced melanoma
Q34482125ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K.
Q38083979Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities
Q36582547Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma
Q36985669Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation
Q38982765Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production
Q28534949Integrative modelling of the influence of MAPK network on cancer cell fate decision
Q34971882Interplay Between HGF/SF-Met-Ras Signaling, Tumor Metabolism and Blood Flow as a Potential Target for Breast Cancer Therapy
Q36253975MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia
Q36764687MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance
Q26795510Managing Side Effects of Vemurafenib Therapy for Advanced Melanoma
Q27685364Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
Q36301783Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
Q51287971Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress
Q35911350Personalized therapy in endometrial cancer: Challenges and opportunities
Q36086845Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer
Q36731185Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know
Q38791244Resolution of inflammation: a new therapeutic frontier
Q40072841Signature of microsatellite instability, KRAS and BRAF gene mutations in German patients with locally advanced rectal adenocarcinoma before and after neoadjuvant 5-FU radiochemotherapy

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