Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts

scientific article published on 28 September 2010

Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1018940730
P356DOI10.1186/1471-2407-10-515
P932PMC publication ID2955043
P698PubMed publication ID20920162
P5875ResearchGate publication ID47335377

P50authorDavid HedleyQ54282536
Jeffrey N MinerQ115235146
P2093author name stringMark S Chapman
Qing Chang
P2860cites workPotential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancerQ24685746
RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancerQ27657185
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseQ29620396
The two TORCs and Akt.Q34617423
Targeting the mitogen-activated protein kinase cascade to treat cancerQ35968411
The Akt-mTOR tango and its relevance to cancerQ36260264
Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts.Q37177892
Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft modelsQ39763382
AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC).Q39775573
Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenograftsQ40220268
The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferationQ40432178
Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplantsQ40439754
Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinomaQ43279511
Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice.Q43763050
Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts.Q43770303
Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xeQ45285589
Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppressionQ46868532
The role of fludarabine-induced apoptosis and cell cycle synchronization in enhanced murine tumor radiation response in vivoQ72789935
An in vivo platform for translational drug development in pancreatic cancerQ80087890
P4510describes a project that usesImageQuantQ112270642
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
sirolimusQ32089
xenograftQ64148587
P304page(s)515
P577publication date2010-09-28
P1433published inBMC CancerQ326300
P1476titleAntitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts
P478volume10

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cites work (P2860)
Q47098844Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma
Q24608066Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism
Q39119302Imaging Mass Cytometry
Q34406302K-RAS Mutant Pancreatic Tumors Show Higher Sensitivity to MEK than to PI3K Inhibition In Vivo
Q34036341MEK and the inhibitors: from bench to bedside
Q37872791MEK inhibitors: a patent review 2008 – 2010
Q38179145MEK1/2 inhibitors in the treatment of gynecologic malignancies.
Q89086204Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells
Q36174910Molecular targeted approaches for treatment of pancreatic cancer.
Q27852097Multicenter Phase I Trial of the Mitogen-Activated Protein Kinase 1/2 Inhibitor BAY 86-9766 in Patients with Advanced Cancer
Q26787087Novel agents for advanced pancreatic cancer
Q37828536Novel mitogen-activated protein kinase kinase inhibitors
Q38193520Prospects for MEK inhibitors for treating cancer.
Q34307356Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance
Q39426747Synergistic anti-tumor effects of RAD001 with MEK inhibitors in neuroendocrine tumors: A potential mechanism of therapeutic limitation of mTOR inhibitor
Q35018805Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models
Q35537413Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle
Q38053855Targeting the Ras-ERK pathway in pancreatic adenocarcinoma.
Q38270129The biology and clinical development of MEK inhibitors for cancer

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