| scholarly article | Q13442814 |
| P50 | author | Ming-Sound Tsao | Q47492209 |
| P2093 | author name string | D W Hedley | |
| T Nicklee | |||
| S S Ng | |||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | pancreatic cancer | Q212961 |
| gemcitabine | Q414143 | ||
| xenograft | Q64148587 | ||
| phosphorylation | Q242736 | ||
| P304 | page(s) | 3269-3275 | |
| P577 | publication date | 2001-10-01 | |
| P1433 | published in | Clinical Cancer Research | Q332253 |
| P1476 | title | Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice | |
| P478 | volume | 7 |
| Q33620076 | A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate |
| Q34313117 | Activation of c-Jun NH2-terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells |
| Q37177892 | Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts. |
| Q42426022 | Akt2 and Akt3 play a pivotal role in malignant gliomas |
| Q38142539 | Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi. |
| Q33709656 | Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts |
| Q24800170 | Apoptosis: targets in pancreatic cancer |
| Q36835642 | Apoptotic pathways in pancreatic ductal adenocarcinoma |
| Q33899938 | Biological approaches to therapy of pancreatic cancer |
| Q36084097 | CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis |
| Q38425940 | Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer |
| Q52681396 | Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation. |
| Q90376957 | Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling |
| Q54979207 | Combination of PI3K/Akt Pathway Inhibition and Plk1 Depletion Can Enhance Chemosensitivity to Gemcitabine in Pancreatic Carcinoma. |
| Q34603280 | Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways |
| Q28538024 | Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability |
| Q41680911 | Cytotoxic effects exerted by pentachlorophenol by targeting nodal pro-survival signaling pathways in human pancreatic cancer cells |
| Q36445102 | Dual role of autophagy in HIV-1 replication and pathogenesis |
| Q47170368 | Effect of arenobufagin on human pancreatic carcinoma cells |
| Q38946429 | Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies |
| Q34384695 | Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway |
| Q37119968 | HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma |
| Q94453056 | Impact of ethanolic extract of Equisetum arvense (EA1) on pancreatic carcinoma AsPC-1 cells |
| Q36648105 | Incidence, mechanism and prognostic value of activated AKT in pancreas cancer |
| Q35719620 | Inhibition of AKT2 enhances sensitivity to gemcitabine via regulating PUMA and NF-κB signaling pathway in human pancreatic ductal adenocarcinoma |
| Q45555100 | Inhibition of Phosphatidylinositol 3-kinease suppresses formation and progression of experimental abdominal aortic aneurysms |
| Q39165812 | Insulin-like growth factor 1 receptor promotes the growth and chemoresistance of pancreatic cancer |
| Q92068154 | Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation |
| Q40206683 | Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma |
| Q39695611 | Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma |
| Q39250668 | Molecular predictors of gemcitabine response in pancreatic cancer |
| Q40343052 | Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo |
| Q53700817 | Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10. |
| Q47805260 | PI3K inhibition protects mice from NAFLD by down-regulating CMKLR1 and NLRP3 in Kupffer cells |
| Q37627237 | PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer |
| Q54113534 | PI3K/AKT/mTOR pathway inhibitors inhibit the growth of melanoma cells with mTOR H2189Y mutations in vitro. |
| Q89983732 | PROM2 promotes gemcitabine chemoresistance via activating the Akt signaling pathway in pancreatic cancer |
| Q35693011 | Pharmacological modulation of autophagy to protect cardiomyocytes according to the time windows of ischaemia/reperfusion |
| Q58586943 | Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol |
| Q36922913 | Prediction of functional phosphorylation sites by incorporating evolutionary information |
| Q36769980 | Promise and progress for functional and molecular imaging of response to targeted therapies. |
| Q37324457 | RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance |
| Q36983840 | Regulation of cell apoptosis and proliferation in pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1. |
| Q35991577 | Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery. |
| Q28066950 | Role of Akt signaling in resistance to DNA-targeted therapy |
| Q64940849 | Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells. |
| Q64962788 | Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer. |
| Q40268278 | Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma |
| Q33899923 | Targeted therapies for pancreatic cancer |
| Q30539569 | Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. |
| Q41912427 | Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells |
| Q36742629 | Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations |
| Q34260205 | Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells |
| Q51242782 | Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson's Disease Mice. |
| Q35194201 | The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1. |
| Q42991719 | The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance |
| Q36761584 | The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth |
| Q36020360 | The role of Akt activation in the response to chemotherapy in pancreatic cancer |
| Q93046345 | Therapeutic Effect of pHLIP-mediated CEACAM6 Gene Silencing in Lung Adenocarcinoma |
| Q35854134 | Up-regulation of VEGF and its receptor in refractory leukemia cells. |
| Q42530564 | Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells |
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