Dysregulation of Met receptor tyrosine kinase activity in invasive tumors

scientific article

Dysregulation of Met receptor tyrosine kinase activity in invasive tumors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI0215418
P932PMC publication ID150937
P698PubMed publication ID11927612

P2093author name stringAlla Danilkovitch-Miagkova
Berton Zbar
P2860cites workCross-talk between the proto-oncogenes Met and RonQ22254408
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto-oncogene (hepatocyte growth factor receptor).Q33238614
Cross-talk between CD44 and c-Met in B cellsQ33681252
Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.Q33963349
Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathwayQ33969327
The cadherin-catenin adhesion system in signaling and cancerQ34124023
Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinaseQ34358610
Invasive growth: from development to metastasisQ34584035
Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic miceQ36326357
Activating mutations for the Met tyrosine kinase receptor in human cancerQ36595980
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growthQ36734562
Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumorsQ37356573
Cellular adherence elicits ligand-independent activation of the Met cell-surface receptorQ37404891
A novel germ line juxtamembrane Met mutation in human gastric cancerQ40847293
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cellsQ40893206
Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytesQ41900830
Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors.Q42279434
Structural and functional domains critical for constitutive activation of the HGF-receptor (Met).Q42798119
Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.Q42800257
Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC familyQ42812959
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.Q42815807
Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.Q42824006
Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studiesQ42828980
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Different point mutations in the met oncogene elicit distinct biological propertiesQ53413979
Evidence for non-covalent clusters of the c-met proto-oncogene productQ54269961
Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-MetQ58324027
Constitutive activation of c-Met in liver metastatic B16 melanoma cells depends on both substrate adhesion and cell density and is regulated by a cytosolic tyrosine phosphatase activityQ71246262
The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuitQ72560868
Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expressionQ73004517
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomasQ73586595
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomasQ77931840
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)863-867
P577publication date2002-04-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleDysregulation of Met receptor tyrosine kinase activity in invasive tumors
P478volume109

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cites work (P2860)
Q38083828A call to ARMS: targeting thePAX3-FOXO1gene in alveolar rhabdomyosarcoma
Q39692077A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor
Q39503071Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer
Q35551938Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells
Q24633986An overview of the c-MET signaling pathway
Q35222611Analysis of MET genetic aberrations in patients with breast cancer at MD Anderson Phase I unit
Q33649756Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review
Q35041627Animal models of melanoma: an HGF/SF transgenic mouse model may facilitate experimental access to UV initiating events
Q38160838Antiangiogenic treatment in hepatocellular carcinoma: the balance of efficacy and safety
Q37312433Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation
Q37750050C-MET as a new therapeutic target for the development of novel anticancer drugs
Q36101108C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression
Q34440437CD34+/CD38− acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells
Q39841653Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors
Q37894860Caveolins in rhabdomyosarcoma
Q37505664Cell and molecular biology of the novel protein tyrosine-phosphatase-interacting protein 51.
Q38222270Challenges in first line chemotherapy and targeted therapy in advanced gastric cancer
Q37317264Chronic arsenic trioxide exposure leads to enhanced aggressiveness via Met oncogene addiction in cancer cells
Q52640291Cigarette smoke enhances oncogene addiction to c-MET and desensitizes EGFR-expressing non-small cell lung cancer to EGFR TKIs.
Q84584265Clinical significance of serum hepatocyte growth factor and epidermal growth factor gene somatic mutations in patients with non-squamous non-small cell lung cancer receiving gefitinib or erlotinib
Q49414583Clinicopathological impacts of high c-Met expression in head and neck squamous cell carcinoma: a meta-analysis and review
Q47103399Clinicopathological impacts of high c-Met expression in renal cell carcinoma: a meta-analysis and review
Q37446964Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer
Q34978329Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models
Q31062741Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607
Q42049311Critical Role of S1PR1 and Integrin β4 in HGF/c-Met-mediated Increases in Vascular Integrity
Q38372437Crizotinib in the management of advanced-stage non-small-cell lung cancer.
Q24647566Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
Q36452714Current status and perspective of antiangiogenic therapy for cancer: urinary cancer
Q37137050Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition.
Q39500213Decorin and chondroitin‐6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification
Q37263981Decorin is a novel antagonistic ligand of the Met receptor
Q39890089Deletion of the ectodomain unleashes the transforming, invasive, and tumorigenic potential of the MET oncogene
Q38912279Development of antibody-based c-Met inhibitors for targeted cancer therapy
Q40075732Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.
Q41463125Differential expression of genes encoding proteins of the HGF/MET system in insulinomas
Q24608143Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197
Q28505611Divergent functions of murine Pax3 and Pax7 in limb muscle development
Q36413232Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation
Q34782774Drug development of MET inhibitors: targeting oncogene addiction and expedience
Q38941681FOXC2 promotes colorectal cancer metastasis by directly targeting MET.
Q49619487First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors
Q36287691Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer
Q35550045Functional consequence of the MET-T1010I polymorphism in breast cancer
Q28186796Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
Q40572436GW domains of the Listeria monocytogenes invasion protein InlB are required for potentiation of Met activation
Q39545863Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells
Q96610153Genomic profiling in renal cell carcinoma
Q34442918Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation
Q33919993Hepatocyte growth factor promotes lymphatic vessel formation and function
Q37225326Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer
Q40961095Impact of MET inhibition on small-cell lung cancer cells showing aberrant activation of the hepatocyte growth factor/MET pathway.
Q39404792Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation
Q39310636Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K–Akt signaling
Q44737495Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy
Q38859217Inhibition of ligand-independent constitutive activation of the Met oncogenic receptor by the engineered chemically-modified antibody DN30.
Q40431244Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor
Q34603045Integrins in invasive growth
Q34971882Interplay Between HGF/SF-Met-Ras Signaling, Tumor Metabolism and Blood Flow as a Potential Target for Breast Cancer Therapy
Q24295561Interplay between scatter factor receptors and B plexins controls invasive growth
Q28253680Invasive growth: a MET-driven genetic programme for cancer and stem cells
Q34584035Invasive growth: from development to metastasis
Q39007909Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis
Q51320328Loss of MicroRNA-489-3p promotes osteosarcoma metastasis by activating PAX3-MET pathway
Q40135925Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
Q91789111MET Oncogene in Non-Small Cell Lung Cancer: Mechanism of MET Dysregulation and Agents Targeting the HGF/c-Met Axis
Q82286267MET Signaling Pathway: A Rational Target for Cancer Therapy
Q54729777MET Y1253D-activating point mutation and development of distant metastasis in advanced head and neck cancers.
Q37485001MET abnormalities in patients with genitourinary malignancies and outcomes with c-MET inhibitors
Q38260120MET and Small-Cell Lung Cancer
Q58164582MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients
Q45968290MET inhibitors in advanced non-small-cell lung cancer: a meta-analysis and review.
Q33273821MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions
Q38956316MET overexpression and gene amplification in NSCLC: a clinical perspective.
Q35208173MET phosphorylation predicts poor outcome in small cell lung carcinoma and its inhibition blocks HGF-induced effects in MET mutant cell lines
Q51689102MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.
Q38675350MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy.
Q47947817Management of Atypical Renal Cell Carcinomas
Q53580017Maxillary carcinosarcoma: Identification of a novel MET mutation in both carcinomatous and sarcomatous components through next generation sequencing.
Q28077785Mechanism of c-MET in Non-small Cell Lung Cancer and Its Treatment and Testing
Q33654173Met degradation by SAIT301, a Met monoclonal antibody, reduces the invasion and migration of nasopharyngeal cancer cells via inhibition of EGR-1 expression
Q28235183Met, metastasis, motility and more
Q39153274Met-induced membrane blebbing leads to amoeboid cell motility and invasion
Q34412493MicroRNA-1 in Cardiac Diseases and Cancers
Q24648202MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development
Q48246859Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors.
Q37876081Molecular Imaging for Guiding Oncologic Prognosis and Therapy in Esophageal Adenocarcinoma
Q45826769Molecular genetic analysis of the hepatocyte growth factor/MET signaling pathway in pediatric medulloblastoma
Q30372506Mutation-introduced dimerization of receptor tyrosine kinases: from protein structure aberrations to carcinogenesis.
Q40427081Negative feedback regulation of Met-dependent invasive growth by Notch
Q28828215Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met
Q37828536Novel mitogen-activated protein kinase kinase inhibitors
Q39675235Nuclear and cytoplasmic expression of Met in oral squamous cell carcinoma and in an organotypic oral cancer model
Q46976409Oncogenic Met receptor induces ectopic structures in Xenopus embryos.
Q35754163P-selectin activates integrin-mediated colon carcinoma cell adhesion to fibronectin
Q41553643PD-L1 and c-MET expression and survival in patients with small cell lung cancer
Q30917936PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells
Q37883394Paradoxical action of growth factors: antiproliferative and proapoptotic signaling by HGF/c-MET.
Q80371652Pharmacokinetics and safety of a fully human hepatocyte growth factor antibody, AMG 102, in cynomolgus monkeys
Q38450015Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynx
Q57493808Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis
Q55145107Prognostic value of MET copy number gain in non-small-cell lung cancer: an updated meta-analysis.
Q47139946Prognostic value of c-Met overexpression in hepatocellular carcinoma: a meta-analysis and review
Q40456936RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.
Q51335207Regulation of HGF and c-MET Interaction in Normal Ovary and Ovarian Cancer
Q37973827Rhabdomyosarcomas: an overview on the experimental animal models.
Q33648325STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant
Q91931124Selection and characterization of FcεRI phospho-ITAM specific antibodies
Q37730020Selection criteria for c-Met-targeted therapies: emerging evidence for biomarkers
Q39385631Sensitivity of Selected Human Tumor Models to PF-04217903, a Novel Selective c-Met Kinase Inhibitor
Q92669216Significance of PD-L1 clones and C-MET expression in hepatocellular carcinoma
Q58164852Silencing the MET oncogene leads to regression of experimental tumors and metastases
Q34094632Small molecule c-Met kinase inhibitors: a review of recent patents
Q35040797Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents
Q64986290Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.
Q58726253Status of Agents Targeting the HGF/c-Met Axis in Lung Cancer
Q38922319Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery.
Q33760876Sunscreen effects on UV-induced immune suppression
Q40672745Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.
Q52547784Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis
Q41969702Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer
Q35525917TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation
Q34309927Targeting MET Amplification as a New Oncogenic Driver.
Q55032209Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma.
Q24606259Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy
Q38297235Targeting the MET pathway for potential treatment of NSCLC.
Q28254690The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants
Q58566840The Role of PI3K in Met Driven Cancer: A Recap
Q41945861The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice
Q39760115The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells
Q37621003The function, proteolytic processing, and histopathology of Met in cancer
Q36158717Therapeutic targeting of receptor tyrosine kinases in lung cancer
Q40626260Tyrosine kinase signal specificity: lessons from the HGF receptor
Q33823715Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells
Q37962905c-MET as a potential therapeutic target and biomarker in cancer
Q38923535c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma

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