Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.

scientific article published on June 2000

Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1012488570
P356DOI10.1038/SJ.ONC.1203628
P698PubMed publication ID10871851
P5875ResearchGate publication ID12446707

P2093author name stringSchmidt L
Zbar B
Nakaigawa N
Weirich G
P2860cites workIdentification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene ProductQ24310794
Paxillin: a new vinculin-binding protein present in focal adhesionsQ24678834
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanismQ30193362
Identification and characterization of a novel cytoskeleton-associated pp60src substrateQ30195583
Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformationQ30450902
Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotypeQ35787720
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core proteinQ36214322
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cellsQ36236279
Activating mutations for the Met tyrosine kinase receptor in human cancerQ36595980
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growthQ36734562
Chromosome imbalances in papillary renal cell carcinoma and first cytogenetic data of familial cases analyzed by comparative genomic hybridizationQ36842062
Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virusQ37392123
Molecular cytogenetics of renal cell tumorsQ40715328
Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene productQ40794270
Hereditary papillary renal cell carcinomaQ40814773
c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cellsQ40990822
Activation and translocation of c-Src to the cytoskeleton by both platelet-derived growth factor and epidermal growth factorQ41370996
MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potentialQ42809617
Activating mutations in the Met receptor overcome the requirement for autophosphorylation of tyrosines crucial for wild type signalingQ42810811
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.Q42815807
Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.Q42824006
Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the ron receptorQ42826965
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virusQ45802101
P433issue26
P407language of work or nameEnglishQ1860
P304page(s)2996-3002
P577publication date2000-06-01
P1433published inOncogeneQ1568657
P1476titleTumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.
P478volume19

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cites work (P2860)
Q42809894A direct role for Met endocytosis in tumorigenesis.
Q40373004Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity
Q47116036Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation
Q34002709Cancer driver mutations in protein kinase genes
Q30374663Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.
Q40075732Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.
Q34584046Dysregulation of Met receptor tyrosine kinase activity in invasive tumors
Q39214964HGF–MET Cascade, a Key Target for Inhibiting Cancer Metastasis: The Impact of NK4 Discovery on Cancer Biology and Therapeutics
Q44737495Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy
Q30415408Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells
Q33969327Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway
Q38031834Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer
Q28212407Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition
Q33510934Sequence and structure signatures of cancer mutation hotspots in protein kinases
Q42828980Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies
Q40343230Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases
Q39876378The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction
Q37765586Understanding the molecular genetics of renal cell neoplasia: implications for diagnosis, prognosis and therapy

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