Targeting the MET pathway for potential treatment of NSCLC.

scientific article published on 23 December 2014

Targeting the MET pathway for potential treatment of NSCLC. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/14728222.2014.995093
P698PubMed publication ID25532429

P2093author name stringYi-Long Wu
Anna Li
Hong-Fei Gao
P2860cites workRationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancerQ47992122
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Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptorsQ24339620
The MET axis as a therapeutic targetQ24609682
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinibQ24646295
Somatic mutations affect key pathways in lung adenocarcinomaQ24648102
MET gene copy number predicts worse overall survival in patients with non-small cell lung cancer (NSCLC); a systematic review and meta-analysisQ26823626
Prognostic significance of MET amplification and expression in gastric cancer: a systematic review with meta-analysisQ27027981
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Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangementQ27852650
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A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivoQ28270305
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MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinibQ35666332
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A germline variant N375S in MET and gastric cancer susceptibility in a Chinese populationQ36732888
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Prognostic value of MET, cyclin D1 and MET gene copy number in non-small cell lung cancerQ36878125
Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and PrognosisQ36953116
Expression and mutational analysis of MET in human solid cancersQ36975055
Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancerQ37111358
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MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients.Q37321772
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitorsQ37399525
Ethnic differences and functional analysis of MET mutations in lung cancerQ37399540
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Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivoQ37733681
MET Signaling: Novel Targeted Inhibition and Its Clinical Development in Lung CancerQ37975092
Targeting the MET gene for the treatment of non-small-cell lung cancerQ38172700
cMET in triple-negative breast cancer: is it a therapeutic target for this subset of breast cancer patients?Q38236096
Mechanisms of hepatocyte growth factor activation in cancer tissuesQ38255480
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer.Q38409218
Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survivalQ38441644
MiR-181a-5p is downregulated in hepatocellular carcinoma and suppresses motility, invasion and branching-morphogenesis by directly targeting c-MetQ38972160
Crizotinib inhibits migration and expression of ID1 in MET-positive lung cancer cells: implications for MET targeting in oncologyQ39027803
Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer.Q39315725
Activation of ERK–p53 and ERK-Mediated Phosphorylation of Bcl-2 Are Involved in Autophagic Cell Death Induced by the c-Met Inhibitor SU11274 in Human Lung Cancer A549 CellsQ39370977
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancersQ39430432
Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor GrowthQ39472261
A Novel Kinase Inhibitor, INCB28060, Blocks c-MET–Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3Q39473718
Met gene copy number predicts the prognosis for completely resected non-small cell lung cancerQ39911616
Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.Q39985982
MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort.Q40108065
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Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.Q40453775
Two mutations affecting conserved residues in the Met receptor operate via different mechanismsQ42621322
MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET AlterationsQ42731321
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.Q42815807
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor statusQ43164574
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancersQ43598203
MET and phosphorylated MET as potential biomarkers in lung cancerQ45329018
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Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status.Q45933831
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P433issue5
P407language of work or nameEnglishQ1860
P304page(s)663-674
P577publication date2014-12-23
P13046publication type of scholarly workreview articleQ7318358
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleTargeting the MET pathway for potential treatment of NSCLC.
P478volume19

Reverse relations

cites work (P2860)
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