Two mutations affecting conserved residues in the Met receptor operate via different mechanisms

scientific article published on March 2000

Two mutations affecting conserved residues in the Met receptor operate via different mechanisms is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049824156
P356DOI10.1038/SJ.ONC.1203431
P698PubMed publication ID10713677
P5875ResearchGate publication ID12601517

P2093author name stringPonzetto C
Accornero P
Maritano D
Bonifaci N
P2860cites workSequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptorsQ24339620
Crystal structure of the tyrosine kinase domain of the human insulin receptorQ27730800
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanismQ27733279
Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificitiesQ28277591
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor familyQ28285975
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle developmentQ28295203
Scatter factor/hepatocyte growth factor is essential for liver developmentQ28504542
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budQ28506228
Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3Q28579880
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analogQ29616450
Catalytic specificity of protein-tyrosine kinases is critical for selective signallingQ29616451
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitroQ30450983
Receptor signaling: when dimerization is not enoughQ33723925
A point mutation in the MET oncogene abrogates metastasis without affecting transformation.Q33731936
Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinaseQ34358610
Activating mutations for the Met tyrosine kinase receptor in human cancerQ36595980
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growthQ36734562
The mutationally activated Met receptor mediates motility and metastasisQ36735738
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1Q37048166
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit productQ38315689
Emerging multipotent aspects of hepatocyte growth factorQ41066829
Expression and characterization of biologically active human hepatocyte growth factor (HGF) by insect cells infected with HGF-recombinant baculovirusQ41070311
The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cellsQ41563732
"Invasive-growth" signaling by the Met/HGF receptor: the hereditary renal carcinoma connection.Q41679360
Autoregulatory mechanisms in protein-tyrosine kinasesQ41758716
Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonistsQ42810535
Activating mutations in the Met receptor overcome the requirement for autophosphorylation of tyrosines crucial for wild type signalingQ42810811
Mechanism of met oncogene activationQ42811433
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.Q42815807
Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.Q42824006
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Switching Signals On or Off by Receptor DimerizationQ46100759
Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agentsQ47801960
Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric ReactionQ57281116
One gene—four syndromesQ59096823
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1354-1361
P577publication date2000-03-01
P1433published inOncogeneQ1568657
P1476titleTwo mutations affecting conserved residues in the Met receptor operate via different mechanisms
P478volume19

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cites work (P2860)
Q112053038Advances in Renal Cell Carcinoma Drug Resistance Models
Q40070648Biological role of the HGF/MET ligand/receptor couple in bovine mammary epithelial cells.
Q34002709Cancer driver mutations in protein kinase genes
Q30374663Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.
Q42825226Differential requirement of the last C-terminal tail of Met receptor for cell transformation and invasiveness.
Q38735120Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers.
Q44226606Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase activity.
Q55285319Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors.
Q36868642Initial Clinical Sensitivity and Acquired Resistance to MET Inhibition in MET-Mutated Papillary Renal Cell Carcinoma
Q28214703K252a inhibits the oncogenic properties of Met, the HGF receptor
Q38445359NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants
Q40456936RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis.
Q33510934Sequence and structure signatures of cancer mutation hotspots in protein kinases
Q24307789Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase
Q38297235Targeting the MET pathway for potential treatment of NSCLC.

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