Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.

scientific article published on 25 June 2018

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/JCS.213314
P932PMC publication ID6031383
P698PubMed publication ID29848659

P50authorGang LiuQ88923475
Yoosun JooQ88923477
Kevin OuQ88923480
Saurabh Ghosh RoyQ88923482
Aimee L EdingerQ88923484
P2093author name stringJingwen Yu
Alison N McCracken
Jannett Nguyen
Elizabeth M Selwan
Brendan T Finicle
Manuel U Ramirez
Dania Virginia Corrales
Victor D Mendoza
P2860cites workMICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recyclingQ24311828
Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesisQ24338641
MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8aQ24338812
The eisosome core is composed of BAR domain proteinsQ24599419
Pathways and mechanisms of endocytic recyclingQ24625970
Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathwayQ24653956
Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkersQ27023509
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasionQ27309213
NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancerQ27310099
Novel functions for the endocytic regulatory proteins MICAL-L1 and EHD1 in mitosisQ27346737
Eisosomes mark static sites of endocytosis.Q27933330
Requirements of Slm proteins for proper eisosome organization, endocytic trafficking and recycling in the yeast Saccharomyces cerevisiaeQ27933842
The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress.Q27937386
The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.Q27939090
ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal MelanomaQ28115305
The structural requirements for ceramide activation of serine-threonine protein phosphatasesQ28189436
Invasive growth: a MET-driven genetic programme for cancer and stem cellsQ28253680
Recycling and EH domain proteins at the synapseQ28264561
Principles of bioactive lipid signalling: lessons from sphingolipidsQ28265743
Cytohesins/ARNO: the function in colorectal cancer cellsQ28540770
Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cellsQ28729071
Endocytic recyclingQ29547737
Ceramide triggers budding of exosome vesicles into multivesicular endosomesQ29616811
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase DQ30307678
Characterization of a fast cycling ADP-ribosylation factor 6 mutantQ30309896
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains.Q30444590
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathwayQ30448719
Requirement for Arf6 in breast cancer invasive activitiesQ33696335
Discovery of new cargo proteins that enter cells through clathrin-independent endocytosisQ33787962
Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiaeQ34084790
Clathrin-independent endocytosis: a cargo-centric viewQ34149489
GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculationQ34426263
SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegansQ34442163
Attacking the supply wagons to starve cancer cells to deathQ34516773
Exchange factor EFA6R requires C-terminal targeting to the plasma membrane to promote cytoskeletal rearrangement through the activation of ADP-ribosylation factor 6 (ARF6).Q34580319
Dysregulation of Met receptor tyrosine kinase activity in invasive tumorsQ34584046
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosisQ34624835
Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistanceQ34657306
Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.Q34718118
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.Q34726188
FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibitionQ47126749
Ceramide activates heterotrimeric protein phosphatase 2A.Q48246807
Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth.Q51813835
An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis.Q53193713
Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysisQ73675805
Sphingolipids are potential heat stress signals in SaccharomycesQ73889990
Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiaeQ74105889
Overexpression of the ARF1 exchange factor ARNO inhibits the early secretory pathway and causes the disassembly of the Golgi complexQ77465533
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesiclesQ35148002
Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membraneQ35197211
ARF family G proteins and their regulators: roles in membrane transport, development and disease.Q35632439
Biologically active sphingolipids in cancer pathogenesis and treatmentQ35852313
An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells.Q36255652
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteinsQ36266670
ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigationQ36274890
ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasisQ36278707
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesisQ36539110
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.Q36564705
MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cellsQ36610951
Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuseQ36698092
Distinct compartmentalization of TGN46 and beta 1,4-galactosyltransferase in HeLa cells.Q36851941
Ceramide starves cells to death by downregulating nutrient transporter proteinsQ36971061
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivoQ37142879
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodelingQ37223988
Loss of TSC2 confers resistance to ceramide and nutrient deprivationQ37381660
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathwaysQ37395800
The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasisQ37651978
Invading one step at a time: the role of invadopodia in tumor metastasisQ37672635
Ceramide in chemotherapy of tumorsQ37901479
Ceramide-orchestrated signalling in cancer cells.Q38067062
Fungal membrane organization: the eisosome concept.Q38227103
All roads lead to PP2A: exploiting the therapeutic potential of this phosphataseQ38617799
Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in VivoQ38812925
Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recyclingQ38846677
GEP100 regulates epidermal growth factor-induced MDA-MB-231 breast cancer cell invasion through the activation of Arf6/ERK/uPAR signaling pathwayQ39142367
Roles of Arf6 in cancer cell invasion, metastasis and proliferationQ39380855
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.Q39575996
Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6.Q40378604
Ceramide-activated protein phosphatase-2A activity in insulin-secreting cellsQ41074199
Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1.Q41839419
Grp1 plays a key role in linking insulin signaling to glut4 recyclingQ42203057
Analysis of Arf GTP‐Binding Protein Function in CellsQ42388845
GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migrationQ42758493
Rac1 and calmodulin interactions modulate dynamics of ARF6-dependent endocytosis.Q42806256
Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosineQ44931306
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell deathQ46375326
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectsphingolipidsQ410395
P577publication date2018-06-25
P1433published inJournal of Cell ScienceQ1524177
P1476titleSphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6
P478volume131

Reverse relations

cites work (P2860)
Q96135768Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling
Q98613650Ceramides: Nutrient Signals that Drive Hepatosteatosis
Q93350366Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs
Q91173363FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia
Q97643940Metabolic Messengers: ceramides