The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis

scientific article published on 05 March 2013

The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.2003398
P932PMC publication ID3961043
P698PubMed publication ID23462101

P50authorCrislyn D'Souza-SchoreyQ87876205
P2093author name stringDean Y Li
Kirk R Thomas
Lise K Sorensen
Jae Hyuk Yoo
Allie H Grossmann
Zongzhong Tong
Alanna Sedgwick
Sheryl R Tripp
Kenneth F Grossmann
Shannon J Odelberg
Kirill Ostanin
James Clancy
Aaron Rogers
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A member of the Frizzled protein family mediating axis induction by Wnt-5AQ24324119
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WNT5A expression increases during melanoma progression and correlates with outcomeQ39939612
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Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells.Q40337286
Practical spontaneous metastasis model for in vivo therapeutic studies using a human melanomaQ41149974
Fluorescent BODIPY-GTP analogs: real-time measurement of nucleotide binding to G proteinsQ43550155
ADP-ribosylation factors 1 and 6 regulate Wnt/β-catenin signaling via control of LRP6 phosphorylationQ44679998
Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switchingQ45736971
Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activationQ46250097
Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatmentQ46593339
Shifts in cadherin profiles between human normal melanocytes and melanomas.Q47971517
N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cellsQ73812967
Loss of beta-catenin expression associated with disease progression in malignant melanomaQ74451230
Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanomaQ81639122
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4Q28205234
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryosQ28242317
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma modelQ28306770
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migrationQ28348554
Lentiviral vectors to probe and manipulate the Wnt signaling pathwayQ28472995
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor contextQ28510950
Towards an integrated view of Wnt signaling in developmentQ29615175
ARF proteins: roles in membrane traffic and beyondQ29618078
Convergence of Wnt, beta-catenin, and cadherin pathwaysQ29619504
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993Q29619885
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathwayQ30448719
Small-molecule synergist of the Wnt/beta-catenin signaling pathwayQ33282822
Requirement for Arf6 in breast cancer invasive activitiesQ33696335
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenzaQ33875118
Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathwayQ33938454
An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanomaQ33947068
β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistanceQ33999619
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic developmentQ34286592
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.Q34726188
SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell numberQ35086895
The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signallingQ35124049
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesiclesQ35148002
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomasQ35621787
E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptorsQ35810162
ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasisQ36278707
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.Q36489436
Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine stormQ36520971
ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathwayQ37078757
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivoQ37142879
Interplay of cadherin-mediated cell adhesion and canonical Wnt signalingQ37698281
Rethinking the metastatic cascade as a therapeutic targetQ37866635
Wnt5a: its signalling, functions and implication in diseasesQ37868763
In melanoma, beta-catenin is a suppressor of invasion.Q38256043
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptorsQ38501378
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signallingQ38529495
P433issue265
P407language of work or nameEnglishQ1860
P304page(s)ra14
P577publication date2013-03-05
P1433published inScience SignalingQ7433604
P1476titleThe small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis
P478volume6

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