Dabrafenib therapy for advanced melanoma

scientific article

Dabrafenib therapy for advanced melanoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1177/1060028013513009
P698PubMed publication ID24259661

P2093author name stringKevin B Kim
Van Anh Trinh
Jennifer E Davis
Jaime E Anderson
P2860cites workKinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAFQ24298749
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenibQ24594790
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaQ24597152
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutationsQ24632064
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthQ27659493
NRAS mutation status is an independent prognostic factor in metastatic melanomaQ27851695
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.Q27851801
Mutations of the BRAF gene in human cancerQ27860760
Cancer statistics, 2013Q27860762
Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistanceQ28282963
Hepatotoxicity with combination of vemurafenib and ipilimumabQ28288255
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trialQ29614756
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFQ29616828
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensionsQ30486572
Melanoma brain metastases and vemurafenib: need for further investigationQ36512866
Analysis of dermatologic events in vemurafenib-treated patients with melanomaQ36714398
Brain and leptomeningeal metastases from cutaneous melanoma: survival outcomes based on clinical featuresQ37036930
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitorsQ37048053
Novel mitogen-activated protein kinase kinase inhibitorsQ37828536
Cutaneous side effects of inhibitors of the RAS/RAF/MEK/ERK signalling pathway and their managementQ38005994
Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanomaQ38026916
Resistance to BRAF-targeted therapy in melanomaQ38071800
Which drug, and when, for patients with BRAF-mutant melanoma?Q38078136
Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trialsQ38502534
Determinants of outcome in melanoma patients with cerebral metastasesQ38517839
Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.Q39610715
Novel treatments for metastatic cutaneous melanoma and the management of emergent toxicities.Q40298916
Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma.Q41675125
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trialQ44442912
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.Q54610975
MelanomaQ56428909
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)519-529
P577publication date2013-11-20
P1433published inAnnals of PharmacotherapyQ4767858
P1476titleDabrafenib therapy for advanced melanoma
P478volume48

Reverse relations

cites work (P2860)
Q38439387Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition
Q38281838BRAF inhibitors: experience in thyroid cancer and general review of toxicity
Q64986104Dabrafenib and its use in the treatment of metastatic melanoma.
Q50954724Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation
Q38370667Erythema nodosum-like lesions during BRAF inhibitor therapy: Report on 16 new cases and review of the literature
Q35578108Imaging MS in Toxicology: An Investigation of Juvenile Rat Nephrotoxicity Associated with Dabrafenib Administrationa
Q26738377Metastatic disease from uveal melanoma: treatment options and future prospects
Q23923997Safe handling of oral antineoplastic medications: focus on targeted therapeutics in the home setting

Search more.