Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression

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Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011484415
P356DOI10.1186/S12885-016-2199-Z
P932PMC publication ID4772351
P698PubMed publication ID26925841

P2093author name stringYin Liu
Sarah E Woodfield
Kathleen A Scorsone
Linna Zhang
Peter E Zage
P2860cites workAberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patientsQ24294421
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteinsQ24324729
Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group studyQ24658339
Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitorsQ27653491
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 studyQ27852083
Mammalian MAP kinase signalling cascadesQ28204140
Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous cultureQ28245251
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoQ28368373
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21Q28609120
Mitogen-activated protein kinase pathwaysQ29618431
Establishment and characterization of human neuroblastoma cell linesQ31202789
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytomaQ33861173
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcomeQ34031980
Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trialQ34446661
Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling PathwaysQ35729391
UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitorsQ36480984
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutationsQ36641925
Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trialQ37658501
MEK inhibitors: a patent review 2008 – 2010Q37872791
Sensitivity of neuroblastoma to the novel kinase inhibitor cabozantinib is mediated by ERK inhibitionQ38832429
GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.Q39034764
Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor modelsQ39755197
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclQ40093939
Human neuroblastomas and abnormalities of chromosomes 1 and 17.Q40222319
Neurofibromatosis type 1 gene mutations in neuroblastomaQ41579794
Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastomaQ42754992
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumourQ42799715
Human neuroblastoma cells and 13-cis-retinoic acid.Q42818963
Determination of cell surface membrane antigens common to both human neuroblastoma and leukemia-lymphoma cell lines by a panel of 38 monoclonal antibodies.Q48648618
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibitionQ50335943
Transient MEK inhibitor-associated retinopathy in metastatic melanoma.Q50455744
Cytogenetic features of human neuroblastomas and cell lines.Q52733297
Biological classification of cell lines derived from human extra-cranial neural tumorsQ53523979
A full-length 3D structure for MAPK/ERK kinase 2 (MEK2)Q54595233
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectneuroblastomaQ938205
P304page(s)172
P577publication date2016-03-01
P1433published inBMC CancerQ326300
P1476titleBinimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression
P478volume16

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cites work (P2860)
Q64121696Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation
Q92073835Genomic Profile and BRCA-1 Promoter Methylation Status in BRCA Mutated Ovarian Cancer: New Insights in Predictive Biomarkers of Olaparib Response
Q90367882Management of pediatric low-grade glioma
Q90085168Multifocal primary neuroblastoma tumor heterogeneity in siblings with co-occurring PHOX2B and NF1 genetic aberrations
Q37745480Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.
Q38710561Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B.
Q92618072Neurofibromin 1 expression is negatively correlated with malignancy and prognosis of epithelial ovarian cancer
Q89128864Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
Q30238693Overview and recent advances in the treatment of neuroblastoma
Q92240963Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma
Q64970891Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.
Q95840082Regorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun pathways
Q90312207Role of GOLPH3 and TPX2 in Neuroblastoma DNA Damage Response and Cell Resistance to Chemotherapy
Q52597787Too many targets, not enough patients: rethinking neuroblastoma clinical trials.

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