| scholarly article | Q13442814 |
| P50 | author | Loren D. Walensky | Q92710996 |
| Evripidis Gavathiotis | Q59661942 | ||
| P2093 | author name string | Denis E Reyna | |
| Marguerite L Davis | |||
| Gregory H Bird | |||
| P2860 | cites work | tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c | Q24290118 |
| Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function | Q24293924 | ||
| Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak | Q24296478 | ||
| Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins | Q24302494 | ||
| A stapled BID BH3 helix directly binds and activates BAX | Q24307663 | ||
| Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis | Q24307994 | ||
| Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death | Q24312211 | ||
| BID: a novel BH3 domain-only death agonist | Q24320091 | ||
| Hematopoietic malignancies demonstrate loss-of-function mutations of BAX | Q24321995 | ||
| Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax | Q24323186 | ||
| Conformation of the Bax C-terminus regulates subcellular location and cell death | Q24534099 | ||
| Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix | Q24537504 | ||
| Solution structure of BID, an intracellular amplifier of apoptotic signaling | Q27617719 | ||
| Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists | Q27617723 | ||
| Structure of Bax: coregulation of dimer formation and intracellular localization | Q27628839 | ||
| Solution structure of the antiapoptotic protein bcl-2 | Q27630598 | ||
| The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site | Q27640443 | ||
| Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1 | Q27651003 | ||
| BAX activation is initiated at a novel interaction site | Q27652635 | ||
| Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis | Q27734734 | ||
| Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels | Q27860531 | ||
| Using NMRView to visualize and analyze the NMR spectra of macromolecules | Q27860567 | ||
| Errors in protein structures | Q27860776 | ||
| NMR methods for studying protein-protein interactions involved in translation initiation | Q81390819 | ||
| Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains | Q81584715 | ||
| NMRPipe: a multidimensional spectral processing system based on UNIX pipes | Q27860859 | ||
| GROMACS: fast, flexible, and free | Q27860998 | ||
| Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death | Q28363890 | ||
| Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets | Q28910218 | ||
| Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane | Q29616354 | ||
| BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly | Q29617135 | ||
| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics | Q29620467 | ||
| Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2 | Q30493313 | ||
| Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. | Q33502518 | ||
| Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process | Q33569749 | ||
| Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis | Q33854131 | ||
| Bax forms an oligomer via separate, yet interdependent, surfaces | Q33885192 | ||
| The multidomain proapoptotic molecules Bax and Bak are directly activated by heat | Q34212713 | ||
| A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. | Q35917067 | ||
| Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak. | Q36118156 | ||
| Regulated targeting of BAX to mitochondria. | Q36255507 | ||
| Conformational control of Bax localization and apoptotic activity by Pro168. | Q36321947 | ||
| The Bax pore in liposomes, Biophysics | Q36501189 | ||
| Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH. | Q36746298 | ||
| The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins | Q37309119 | ||
| BH3-only proteins and their roles in programmed cell death | Q37566201 | ||
| Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. | Q37593642 | ||
| Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. | Q38268983 | ||
| Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis | Q38326924 | ||
| Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing | Q39576297 | ||
| The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. | Q40485961 | ||
| Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death | Q40732702 | ||
| Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices | Q43235008 | ||
| Involvement of the N-terminus of Bax in its intracellular localization and function. | Q45711449 | ||
| To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions. | Q46142204 | ||
| Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism | Q46159185 | ||
| Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains | Q46500385 | ||
| Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane | Q46765170 | ||
| Optimization and use of peptide mass measurement accuracy in shotgun proteomics | Q50232217 | ||
| BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. | Q52514947 | ||
| TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K | Q64380526 | ||
| Nonionic detergents induce dimerization among members of the Bcl-2 family | Q73343305 | ||
| Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies | Q79370601 | ||
| Complete activation of Bax by a single site mutation | Q80281973 | ||
| Impact of pH on Bax alpha conformation, oligomerisation and mitochondrial integration | Q81100878 | ||
| P433 | issue | 3 | |
| P304 | page(s) | 481-492 | |
| P577 | publication date | 2010-11-01 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | BH3-triggered structural reorganization drives the activation of proapoptotic BAX | |
| P478 | volume | 40 |
| Q38448926 | "Licensed to kill": tyrosine dephosphorylation and Bak activation |
| Q90044884 | A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels |
| Q98293355 | A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy |
| Q30466831 | A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. |
| Q39292731 | A unified model of mammalian BCL-2 protein family interactions at the mitochondria. |
| Q37727610 | After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. |
| Q36012325 | Allosteric inhibition of antiapoptotic MCL-1. |
| Q49261983 | Allosteric sensitization of proapoptotic BAX. |
| Q53424475 | Allostery in BAX protein activation. |
| Q39593727 | An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. |
| Q38387363 | An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology |
| Q36109186 | An interconnected hierarchical model of cell death regulation by the BCL-2 family |
| Q38181031 | Apoptosis regulation at the mitochondrial outer membrane |
| Q39384348 | Apoptotic foci at mitochondria: in and around Bax pores |
| Q28831381 | Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore |
| Q37151053 | Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis |
| Q49725642 | BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove |
| Q36941147 | BAK/BAX activation and cytochrome c release assays using isolated mitochondria |
| Q39073674 | BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells |
| Q27002044 | BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore |
| Q34363841 | BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells |
| Q58573059 | BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis |
| Q36478810 | BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes |
| Q39394965 | BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax |
| Q27677468 | BID-induced structural changes in BAK promote apoptosis |
| Q47254152 | BIM Binding Remotely Regulates BAX Activation: Insights from the Free Energy Landscapes |
| Q39033533 | Bax and Bak Pores: Are We Closing the Circle? |
| Q24313049 | Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis |
| Q41263641 | Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming |
| Q35512551 | Bax forms two types of channels, one of which is voltage-gated |
| Q54989154 | Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance. |
| Q37589942 | Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes |
| Q47305952 | Bax, Bak and beyond - mitochondrial performance in apoptosis |
| Q24298758 | Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol |
| Q24322034 | Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints |
| Q95267785 | Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/β-Catenin Signaling Pathway |
| Q36508651 | Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. |
| Q39661214 | Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment |
| Q28300914 | Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis |
| Q35579307 | CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. |
| Q28248512 | Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation |
| Q36927134 | Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak |
| Q38151753 | Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway |
| Q38855898 | Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. |
| Q28480411 | Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation |
| Q28833483 | Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting |
| Q37067833 | Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation |
| Q38172752 | Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. |
| Q40754542 | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction |
| Q37921609 | Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases |
| Q38115674 | Decoding and unlocking the BCL-2 dependency of cancer cells |
| Q47670493 | Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. |
| Q51015500 | Direct BAKtivation. |
| Q36692849 | Direct activation of full-length proapoptotic BAK |
| Q36741892 | Direct and selective small-molecule activation of proapoptotic BAX |
| Q42087886 | Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. |
| Q38969426 | Disordered clusters of Bak dimers rupture mitochondria during apoptosis. |
| Q38886445 | Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis |
| Q42788323 | Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. |
| Q37686266 | Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes |
| Q41941811 | Effects of Acupuncture on mRNA Levels of Apoptotic Factors in Perihematomal Brain Tissue During the Acute Phase of Cerebral Hemorrhage |
| Q38398064 | Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment. |
| Q41460863 | Examining BCL-2 family function with large unilamellar vesicles |
| Q64056422 | Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation |
| Q38957651 | HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells |
| Q33648382 | High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells |
| Q28542025 | Hydrocarbon-stapled peptides: principles, practice, and progress |
| Q36960198 | Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies |
| Q35679496 | Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain. |
| Q39331696 | Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage |
| Q41432708 | Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. |
| Q39357641 | Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis |
| Q90396260 | Isolation of Synthetic Antibodies Against BCL-2-Associated X Protein (BAX) |
| Q41570585 | Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis |
| Q33432478 | Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). |
| Q47148226 | MOMP, cell suicide as a BCL-2 family business |
| Q38185804 | Many players in BCL-2 family affairs |
| Q47624759 | Measurement of BH3-only protein tolerance. |
| Q36932838 | Mechanisms of action of Bcl-2 family proteins |
| Q35659301 | Mitochondria and apoptosis: emerging concepts. |
| Q90859789 | Mitochondria as multifaceted regulators of cell death |
| Q35165455 | Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. |
| Q36723084 | Mitochondria in human pluripotent stem cell apoptosis |
| Q38820532 | Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. |
| Q38134062 | Mitochondrial regulation of cell death. |
| Q47843948 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. |
| Q33819193 | Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL |
| Q37192687 | Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3 |
| Q87906376 | Neuronal Cell Death |
| Q28393874 | Neurotoxic effect of lead on rats: Relationship to Apoptosis |
| Q38477617 | New dimension in therapeutic targeting of BCL-2 family proteins |
| Q46528923 | Nitrogen Arylation for Macrocyclization of Unprotected Peptides |
| Q35731554 | Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim. |
| Q48162021 | Oligomerization process of Bcl-2 associated X protein revealed from intermediate structures in solution. |
| Q64229946 | Photocrosslinking Approach to Investigate Protein Interactions in the BCL-2 Family |
| Q26853192 | Photoreceptor cell death and rescue in retinal detachment and degenerations |
| Q35987570 | Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis |
| Q30388868 | Pro-apoptotic Bax molecules densely populate the edges of membrane pores |
| Q34328597 | Programming biological models in Python using PySB |
| Q38088109 | Programming cancer cells for high expression levels of Mcl1. |
| Q39452441 | Progress in targeting the BCL-2 family of proteins. |
| Q42869630 | Protein-protein interactions: A PUMA mechanism unfolds |
| Q35469778 | Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy |
| Q55234523 | Pulling the BAX trigger for tumor cell death. |
| Q41009828 | Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation. |
| Q37324058 | Redefining the BH3 Death Domain as a 'Short Linear Motif'. |
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| Q42003162 | S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis |
| Q41374031 | Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. |
| Q41907705 | Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors |
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| Q30381337 | Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. |
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