The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond

scientific article

The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1100/2012/838916
P932PMC publication ID3289992
P698PubMed publication ID22431925
P5875ResearchGate publication ID221724495

P2093author name stringAlexander H. Stegh
Fotini M. Kouri
Samuel A. Jensen
P2860cites workGlioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressorQ24299628
A stapled BID BH3 helix directly binds and activates BAXQ24307663
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Overexpression of bax in human glioma cell lines.Q54080419
Expression of bcl-2 in small cell lung carcinoma cells.Q54218040
Expression of antisense bcl-2 cDNA abolishes tumorigenicity and enhances chemosensitivity of human malignant glioma cells.Q55472578
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphomaQ73555358
EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activitiesQ83045380
Necrotic death as a cell fateQ36359618
The prognostic influence of bcl-2 in malignant gliomaQ36644672
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivoQ36647747
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastomaQ36825199
Cancer stem cells and gliomaQ37217237
Homeostatic functions of BCL-2 proteins beyond apoptosisQ37797382
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapyQ37854419
MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activityQ39679824
BIM induction of apoptosis triggered by EGFR-sensitive and resistance cell lines of non-small-cell lung cancerQ39726300
Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteinsQ39956386
Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrionQ40033557
A role for proapoptotic BID in the DNA-damage responseQ40381562
Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosisQ40511321
BCL-2 family proteins modulate radiosensitivity in human malignant glioma cellsQ40738665
Inhibition of virus-induced neuronal apoptosis by Bax.Q40943846
BH3-triggered structural reorganization drives the activation of proapoptotic BAX.Q41884328
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal developmentQ44399624
Proapoptotic BID is an ATM effector in the DNA-damage responseQ46669145
The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.Q46970879
What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulatorQ48939992
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastomaQ24670606
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3Q28246420
The mitochondrial death squad: hardened killers or innocent bystanders?Q28276624
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimeticsQ28469345
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutationsQ28756824
The BCL-2 protein family: opposing activities that mediate cell deathQ29547380
Malignant gliomas in adultsQ29615708
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 familyQ30168116
Bcl-2 expression in higher-grade human glioma: a clinical and experimental studyQ30321045
Adenoviral natural born killer gene therapy for malignant gliomaQ33188372
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.Q33266778
Gossypol treatment of recurrent adult malignant gliomasQ33329763
Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.Q33618246
Functional delivery of siRNA in mice using dendriwormsQ33686651
The WHO classification of tumors of the nervous systemQ33845646
EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.Q33872371
The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entryQ33887183
A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implicationsQ33900952
STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinomaQ33903747
Cell deathQ34019760
Inhibition of brain tumor growth by intravenous poly(β- l -malic acid) nanobioconjugate with pH-dependent drug releaseQ34241230
Intratumoral mediated immunosuppression is prognostic in genetically engineered murine models of glioma and correlates to immunotherapeutic responsesQ34393758
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastomaQ34621019
Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MG.Q34997130
The CD95(APO-1/Fas) DISC and beyondQ35091401
Bcl-2 promotes malignant progression in a PDGF-B-dependent murine model of oligodendroglioma.Q35388292
BCL-2 family protein expression in initial and recurrent glioblastomas: modulation by radiochemotherapyQ35454275
Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system originQ35763574
Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteasesQ36097402
New approaches and therapeutics targeting apoptosis in diseaseQ36138109
Investigations on gossypol: past and present developmentsQ36300043
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectbrain tumorQ233309
bcl-2 familyQ554446
gliomaQ1365309
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)838916
P577publication date2012-01-01
2012-02-14
P1433published inThe Scientific World JournalQ7762585
P1476titleThe role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond
P478volume2012

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cites work (P2860)
Q58700451Adjuvant Therapy Using Mistletoe Containing Drugs Boosts the T-Cell-Mediated Killing of Glioma Cells and Prolongs the Survival of Glioma Bearing Mice
Q38973191Aplysin enhances temozolomide sensitivity in glioma cells by increasing miR-181 level
Q34517100Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types.
Q60302022Clinical significance and effect of MTDH/AEG-1 in bladder urothelial cancer: a study based on immunohistochemistry, RNA-seq, and in vitro verification
Q38101608Enhancing radiation therapy for patients with glioblastoma
Q37382513Estrogen receptor β isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12.
Q39291616Gliomatosis cerebri type 1 with extensive involvement of the spinal cord and BRAF V600E mutation
Q40511892Optimized mixture of As, Cd and Pb induce mitochondria-mediated apoptosis in C6-glioma via astroglial activation, inflammation and P38-MAPK.
Q37641600Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide
Q90401877Proteinase-activated receptor-2 enhances Bcl2-like protein-12 expression in lung cancer cells to suppress p53 expression
Q35653078Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells
Q42968961The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma.

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