Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide

scientific article published on August 2016

Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.10973
P932PMC publication ID5308652
P698PubMed publication ID27494880

P50authorBrona M MurphyQ58811046
P2093author name stringMarkus Rehm
Birgit C Weyhenmeyer
Frank A Lincoln
Grainne Johnston
Janis Noonan
Maximilian L Würstle
P2860cites workTemozolomide: mechanisms of action, repair and resistanceQ39436413
Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cellsQ39680489
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.Q39753656
Enhancement of tumor-TRAIL susceptibility by modulation of autophagyQ39943681
Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteinsQ39956386
Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant gliomaQ40070342
Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft modelQ40508031
Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells.Q40775835
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.Q40975748
Prognostic factors for glioblastoma patients--a clinical population-based study.Q41377266
Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis proteinQ41834899
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.Q42064781
The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma.Q42968961
The dark side of TRAIL signalingQ43130518
Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cyclesQ43218101
Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomideQ43259949
Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosisQ46448054
Revisiting the role of p53 in primary and secondary glioblastomasQ48314523
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivoQ48548442
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.Q55035703
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.Q55463299
The Scree Test For The Number Of FactorsQ56210944
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic functionQ24293924
Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIPQ24302531
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptorsQ24310559
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptorQ24597543
Onto better TRAILs for cancer treatmentQ26768160
The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyondQ26851645
Small-molecule SMAC mimetics as new cancer therapeuticsQ26864204
Getting TRAIL back on track for cancer therapyQ27027460
MGMT gene silencing and benefit from temozolomide in glioblastomaQ27824832
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Quantitative and logic modelling of molecular and gene networksQ28083248
Apoptosis: controlled demolition at the cellular levelQ29620114
Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cellsQ30549646
Imaging genomics of Glioblastoma: state of the art bridge between genomics and neuroradiologyQ30874551
Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial.Q33245190
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiformeQ33387317
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trialQ33401179
Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trialQ33402747
Tetravalent antibody-scTRAIL fusion proteins with improved propertiesQ33619046
BH3 mimetics: status of the field and new developmentsQ34037924
BH3-only proteins in apoptosis and beyond: an overviewQ34085370
Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cellsQ34321143
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiformeQ34679133
Cancer stem cells in glioblastomaQ35829972
On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeuticsQ35853714
BH3-only proteins in apoptosis at a glanceQ35883875
Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.Q35922585
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosisQ36152548
Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiformeQ36525099
Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in GlioblastomasQ36651893
Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatmentQ36683578
Mechanisms of disease: temozolomide and glioblastoma--look to the futureQ37187383
Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trialQ37278379
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trialQ37325097
Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and TemozolomideQ37356520
TRAIL on trial: preclinical advances in cancer therapyQ37433463
Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant gliomaQ37585453
Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosisQ37610475
Cancer stem cells in glioma: challenges and opportunitiesQ37634973
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeuticsQ37761935
BH3-only proteins: Orchestrators of apoptosisQ37819153
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseasesQ37921609
Cancer stem cell contribution to glioblastoma invasivenessQ38091173
Cellular mechanisms controlling caspase activation and functionQ38111614
Glioblastoma multiforme: a look inside its heterogeneous natureQ38182805
MGMT testing--the challenges for biomarker-based glioma treatmentQ38218848
Molecular heterogeneity of glioblastoma and its clinical relevanceQ38243193
Cell death controlling complexes and their potential therapeutic roleQ38260863
Biomarkers of glioblastoma multiformeQ38281859
Venetoclax: First Global ApprovalQ38853500
Bcl2L12 with a BH3-like domain in regulating apoptosis and TMZ-induced autophagy: a prospective combination of ABT-737 and TMZ for treating glioma.Q38920339
APG350 induces superior clustering of TRAIL receptors and shows therapeutic antitumor efficacy independent of cross-linking via Fcγ receptorsQ39084817
Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatmentQ39167592
Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.Q39208647
ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cellsQ39236559
P4510describes a project that usesImageJQ1659584
P433issue38
P407language of work or nameEnglishQ1860
P921main subjectcell deathQ2383867
temozolomideQ425088
P1104number of pages17
P304page(s)61295-61311
P577publication date2016-08-01
P1433published inOncotargetQ1573155
P1476titlePredicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide
P478volume7

Reverse relations

cites work (P2860)
Q55456993Bufalin induces apoptosis and improves the sensitivity of human glioma stem-like cells to temozolamide.
Q47648800Cdc20 overexpression is involved in temozolomide-resistant glioma cells with epithelial-mesenchymal transition
Q38709582Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling
Q58547260Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism
Q64063271The combined efficacy of OTS964 and temozolomide for reducing the size of power-law coded heterogeneous glioma stem cell populations

Search more.