Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide

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Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide is …
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scholarly articleQ13442814

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P356DOI10.1158/1535-7163.MCT-08-0640
P932PMC publication ID2748233
P698PubMed publication ID19001440
P5875ResearchGate publication ID23465923

P50authorRalph WeisslederQ7288259
P2093author name stringXianghui Ren
Marie Classon
Khalid Shah
Shawn Hingtgen
Ernie Terwilliger
P2860cites workIncreased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAILQ24554360
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MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomasQ40073679
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Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human gliomaQ40261023
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A combination of mutations enhances the neurotropism of AAV-2.Q40384910
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in established and primary glioma cell linesQ40432328
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression.Q40476541
Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft modelQ40508031
Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosisQ40860890
Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regressionQ42835214
Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cellsQ43513023
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CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c releaseQ43682296
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo.Q43713225
Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapyQ44198636
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivoQ44611172
DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair systemQ45025213
Motor and cognitive improvements in patients with Huntington's disease after neural transplantationQ45301920
Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.Q45735544
Cationic albumin-conjugated pegylated nanoparticles allow gene delivery into brain tumors via intravenous administrationQ45864572
Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligandQ46324484
Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safetyQ46661382
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanineQ48479768
In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis.Q55471304
Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.Q55476497
Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) geneQ64379934
P433issue11
P921main subjecttemozolomideQ425088
P304page(s)3575-3585
P577publication date2008-11-01
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleTargeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide
P478volume7

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