Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma.

scientific article published on 26 March 2013

Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/SCD.2012.0529
P932PMC publication ID3685394
P698PubMed publication ID23428290
P5875ResearchGate publication ID235688976

P50authorKam M HuiQ56872772
Berwini EndayaQ59560731
Ivy A W HoQ79316768
P2093author name stringPaula Y P Lam
Yulyana Yulyana
Chang M Guo
Wai H Ng
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Connexin 43 confers resistance to hydrogen peroxide-mediated apoptosis.Q40087234
Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs.Q40287620
Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancerQ40359028
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Inhibition of Connexin 26/43 and Extracellular-Regulated Kinase Protein Plays a Critical Role in Melatonin Facilitated Gap Junctional Intercellular Communication in Hydrogen Peroxide-Treated HaCaT Keratinocyte CellsQ42404459
Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells.Q42833342
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LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptorsQ45866584
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Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationshipsQ46979453
Gap-junction blocker carbenoxolone differentially enhances NMDA-induced cell death in hippocampal neurons and astrocytes in co-cultureQ48220479
Cancer Vaccines in Glioma: How to Balance the Challenges of Small Trials, Efficiency, and Potential Adverse EventsQ53074821
Inhibition of gap junction-mediated intercellular communication by TNF-alpha in cultured human corneal fibroblasts.Q54674022
Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury.Q55045700
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Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung CancerQ60620763
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versionsQ73704158
Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3)Q79843385
Carbenoxolone inhibits junctional transfer and upregulates Connexin43 expression by a protein kinase A-dependent pathwayQ82907665
Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotectionQ83896557
P433issue13
P304page(s)1870-1882
P577publication date2013-03-26
P1433published inStem Cells and DevelopmentQ15724421
P1476titleCarbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma
P478volume22

Reverse relations

cites work (P2860)
Q90575658A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma
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Q42368059Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells
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Q90929877Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells
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Q37049935Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.
Q28076798Role of nanotechnology and gene delivery systems in TRAIL-based therapies
Q90711989Survival of aging CD264+ and CD264- populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency

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