Structural and functional diversity of connexin genes in the mouse and human genome

scientific article

Structural and functional diversity of connexin genes in the mouse and human genome is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1515/BC.2002.076
P698PubMed publication ID12108537
P5875ResearchGate publication ID11269046

P50authorUrban DeutschQ32420081
P2093author name stringKlaus Willecke
Goran Söhl
Joachim Degen
Alessandro Romualdi
Dominik Eckardt
Jürgen Eiberger
Martin Güldenagel
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectfunctional diversityQ113242927
P304page(s)725-737
P577publication date2002-05-01
P1433published inBiological ChemistryQ4914948
P1476titleStructural and functional diversity of connexin genes in the mouse and human genome
P478volume383

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cites work (P2860)
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Q45526506Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration.
Q37769339Cell membrane permeabilization via connexin hemichannels in living and dying cells
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Q44912536Cell-Cell Junctions Organize Structural and Signaling Networks
Q36740282Cell-cell communication in the osteoblast/osteocyte lineage.
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Q36456187Changes in connexin43 expression and localization during pancreatic cancer progression
Q50567646Changes in object recognition and anxiety-like behaviour in mice expressing a Cx47 mutation that causes Pelizaeus-Merzbacher-like disease.
Q46032741Characteristics of ethylnitrosourea-induced cataracts.
Q42183057Characterization of a novel water pocket inside the human Cx26 hemichannel structure
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Q34010878Clinical significance of the expression of connexin26 in colorectal cancer
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Q42639770Cloning and functional expression of invertebrate connexins from Halocynthia pyriformis.
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Q33437222Colocalization of connexin 36 and corticotropin-releasing hormone in the mouse brain
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Q91817535Connexin 26 and Connexin 43 in Canine Mammary Carcinoma
Q35010472Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer
Q54771321Connexin 37 gene is not mutated in lung carcinomas 3LL and CMT.
Q28508603Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum
Q92729411Connexin 43 Functions as a Positive Regulator of Stem Cell Differentiation into Definitive Endoderm and Pancreatic Progenitors
Q34295662Connexin 43 a check-point component of cell proliferation implicated in a wide range of human testis diseases.
Q37058574Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium.
Q41962385Connexin 43 is a potential prognostic biomarker for ewing sarcoma/primitive neuroectodermal tumor
Q24810763Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture
Q55462530Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin.
Q34205721Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS.
Q31080762Connexin 48.5 is required for normal cardiovascular function and lens development in zebrafish embryos
Q36057694Connexin 57 is expressed by the axon terminal network of B-type horizontal cells in the rabbit retina
Q37019005Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles
Q37218997Connexin and pannexin mediated cell-cell communication.
Q38699139Connexin channels in congenital skin disorders.
Q36107147Connexin composition in apposed gap junction hemiplaques revealed by matched double-replica freeze-fracture replica immunogold labeling
Q30587337Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex.
Q52682485Connexin hemichannels mediate glutathione transport and protect lens fiber cells from oxidative stress.
Q36870663Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation
Q37116451Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner
Q36524192Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma.
Q28073076Connexin's Connection in Breast Cancer Growth and Progression
Q41311993Connexin-43 enhances tumor suppressing activity of artesunate via gap junction-dependent as well as independent pathways in human breast cancer cells.
Q24674144Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning
Q44502159Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells
Q44490298Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells
Q24670178Connexin29 expression, immunocytochemistry and freeze-fracture replica immunogold labelling (FRIL) in sciatic nerve
Q28511260Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of mice
Q64967877Connexin30 and Connexin43 show a time-of-day dependent expression in the mouse suprachiasmatic nucleus and modulate rhythmic locomotor activity in the context of chronodisruption.
Q28254582Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea
Q54706476Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development.
Q34049242Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21Cip1 and p27Kip1
Q30485962Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects
Q44763050Connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells
Q35832932Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways
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Q46217913Connexin36, an essential element in the rod pathway, is highly expressed in the essentially rodless retina of Gallus gallus.
Q36743696Connexin37: a potential modifier gene of inflammatory disease.
Q28595070Connexin39 deficient mice display accelerated myogenesis and regeneration of skeletal muscle
Q37118870Connexin43 and the brain transcriptome of newborn mice
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Q38020754Connexin43 cardiac gap junction remodeling: lessons from genetically engineered murine models
Q24295100Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells
Q52108100Connexin43 is expressed in mouse fetal ovary.
Q47767685Connexin43 orthologues in vertebrates: phylogeny from fish to man.
Q44405208Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation
Q35621893Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues
Q36846713Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure.
Q30530110Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone
Q30499651Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain
Q35584623Connexin: a potential novel target for protecting the central nervous system?
Q73668171Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice
Q59359881Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics
Q36946179Connexins and apoptotic transformation
Q42118458Connexins and cyclooxygenase-2 crosstalk in the expression of radiation-induced bystander effects
Q36895379Connexins and gap junctions in mammary gland development and breast cancer progression
Q36031743Connexins and pannexins in neuronal development and adult neurogenesis
Q37983849Connexins and pannexins: Coordinating cellular communication in the testis and epididymis
Q37857716Connexins and the gap in context
Q33841038Connexins and the kidney.
Q50016422Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets.
Q36849393Connexins induce and maintain tight junctions in epithelial cells
Q37526742Connexins, cell motility, and the cytoskeleton
Q21245510Connexins: a myriad of functions extending beyond assembly of gap junction channels
Q36287121Connexon connexions in the thalamocortical system
Q37164105Connexons and cell adhesion: a romantic phase
Q30425814Connexons and pannexons: newcomers in neurophysiology
Q24311880Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins
Q39914592Contractile properties of esophageal striated muscle: comparison with cardiac and skeletal muscles in rats
Q30499066Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice
Q36202777Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function
Q28210913Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines
Q42089141Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct
Q28509175Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development
Q46574879Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways
Q33998452Cx37 deletion enhances vascular growth and facilitates ischemic limb recovery
Q26859920Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals
Q52666789DE-cadherin, a core component of the adherens junction complex modifies subcellular localization of the Drosophila gap junction protein innexin2.
Q44975253Decreased intercellular communication and connexin expression in mouse aortic endothelium during lipopolysaccharide-induced inflammation.
Q30833243Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43.
Q28586045Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission
Q33831809Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body
Q42151901Detection of the GJB2 Mutation in Iranian Children with Hearing Loss Treated with Cochlear Implantation
Q38805573Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus
Q42656536Developmental regulation and expression of the zebrafish connexin43 gene.
Q35676252Developmental regulation of gap junctions and their role in mammary epithelial cell differentiation
Q28505618Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9
Q34979286Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50
Q46572559Differential expression of connexins during histogenesis of the chick retina.
Q42481789Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis
Q50689999Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia.
Q36304831Differential responses of induced pluripotent stem cell-derived cardiomyocytes to anisotropic strain depends on disease status
Q30405820Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation
Q47723180Direct visualization of interaction between calmodulin and connexin45.
Q35209953Disease mechanisms in inherited neuropathies
Q36908171Distinct and gradient distributions of connexin26 and connexin30 in the cochlear sensory epithelium of guinea pigs
Q33721861Divalent regulation and intersubunit interactions of human connexin26 (Cx26) hemichannels.
Q37397290Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models
Q42791910Dominant Cx26 mutants associated with hearing loss have dominant-negative effects on wild type Cx26
Q36323542Dominant cataracts result from incongruous mixing of wild-type lens connexins
Q40519966Dominant connexin26 mutants associated with human hearing loss have trans-dominant effects on connexin30.
Q35546522Downregulation of connexin43 by microRNA-130a in cardiomyocytes results in cardiac arrhythmias.
Q46447814Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells
Q24533504Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells
Q34478062Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica
Q34180119Effect of external magnesium and calcium on human connexin46 hemichannels
Q28573218Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells
Q28481381Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells
Q33976143Electrical coupling and neuronal synchronization in the Mammalian brain
Q48242508Electrical synapses and the development of inhibitory circuits in the thalamus.
Q36778969Electrical synapses in basal ganglia
Q22337387Electrical synapses: a dynamic signaling system that shapes the activity of neuronal networks
Q41461476Emerging trend in second messenger communication and myoendothelial feedback
Q46390138Endothelial connexin32 enhances angiogenesis by positively regulating tube formation and cell migration
Q33676492Engram formation in psychiatric disorders
Q26826431Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance
Q37344013Evolution of energy metabolism, stem cells and cancer stem cells: how the warburg and barker hypotheses might be linked.
Q48081089Evolutionary selection pressure and family relationships among connexin genes
Q34187324Exchange of gating properties between rat cx46 and chicken cx45.6.
Q84014656Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes
Q41763891Expression of a gap junction protein, connexin43, in a large panel of human gliomas: new insights.
Q44824292Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
Q52096946Expression of connexin48.5, connexin44.1, and connexin43 during zebrafish (Danio rerio) lens development.
Q48100887Expression of connexins in embryonic mouse neocortical development
Q24799875Expression of connexins in human preimplantation embryos in vitro
Q42443122Expression of gap junction protein connexin43 in the adult rat cochlea: comparison with connexin26.
Q34317291Expression pattern of lacZ reporter gene representing connexin36 in transgenic mice
Q54997172Expressional Patterns of Connexin Isoforms in the Rat Epididymal Fat during Postnatal Development.
Q64943895Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber.
Q38172363Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms
Q41838330Functional analysis of a nonsyndromic hearing loss-associated mutation in the transmembrane II domain of the GJC3 gene
Q35607498Functional characterization of a naturally occurring Cx50 truncation
Q29030321Functional connexin “hemichannels”: A critical appraisal
Q40587065Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations
Q37575363Functional effects of Cx50 mutations associated with congenital cataracts.
Q45230136Functional imaging: new views on lens structure and function.
Q24299761Functional implications of calcium permeability of the channel formed by pannexin 1
Q28586647Functional properties of mouse connexin30.2 expressed in the conduction system of the heart
Q36579629Functional requirement for a highly conserved charged residue at position 75 in the gap junction protein connexin 32.
Q37261641Further evidence for P59L mutation in GJA3 associated with autosomal dominant congenital cataract
Q37429017GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype
Q37310526Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models.
Q42131038Gap Junction Enhancer Potentiates Cytotoxicity of Cisplatin in Breast Cancer Cells
Q36916597Gap Junctions and Biophysical Regulation of Bone Cells
Q33586541Gap junction blockers: a potential approach to attenuate morphine withdrawal symptoms
Q35700096Gap junction channel gating
Q40902811Gap junction channel protein innexin 2 is essential for epithelial morphogenesis in the Drosophila embryo
Q36895381Gap junction channels and cardiac impulse propagation
Q38797972Gap junction communication dynamics and bystander effects from ultrasoft X-rays
Q35760051Gap junction communication in myelinating glia
Q40358720Gap junction coupling and apoptosis in GFSHR-17 granulosa cells.
Q34427761Gap junction enhancer increases efficacy of cisplatin to attenuate mammary tumor growth
Q35206708Gap junction hemichannels in astrocytes of the CNS.
Q34778768Gap junction intercellular communication: a review of a potential platform to modulate craniofacial tissue engineering
Q21092155Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice
Q33232108Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells
Q38228606Gap junction regulation of vascular tone: implications of modulatory intercellular communication during gestation
Q34687709Gap junction remodeling and cardiac arrhythmogenesis: cause or coincidence?
Q34278660Gap junction-mediated electrical transmission: regulatory mechanisms and plasticity
Q52550218Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters.
Q48800187Gap junctional connexin 37 is expressed in sheep ovaries
Q27012316Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases
Q36231023Gap junctions and hemichannels in signal transmission, function and development of bone
Q36260714Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease
Q24645936Gap junctions couple astrocytes and oligodendrocytes
Q45872003Gap junctions in human glioblastomas: implications for suicide gene therapy
Q37689002Gap junctions in inherited human disease
Q28508885Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals
Q39432975Gap junctions mediate STAT5-independent β-casein expression in CID-9 mammary epithelial cells.
Q37811014Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development.
Q34020827Gap junctions.
Q30490087Gap-junction channels dysfunction in deafness and hearing loss
Q40288658Gap-junctional single-channel permeability for fluorescent tracers in mammalian cell cultures
Q50610349Genomic instability induced in distant progeny of bystander cells depends on the connexins expressed in the irradiated cells.
Q34178313Genomic organization and alternative transcripts of the human Connexin40 gene.
Q37111630Glial connexins and gap junctions in CNS inflammation and disease
Q38952860Glioma-associated microglia and macrophages/monocytes display distinct electrophysiological properties and do not communicate via gap junctions
Q37388212Glycosylation regulates pannexin intermixing and cellular localization
Q35756587Gold nanoparticle-mediated (GNOME) laser perforation: a new method for a high-throughput analysis of gap junction intercellular coupling.
Q28587050Heart and head defects in mice lacking pairs of connexins
Q34973819Hematopoietic cell regulation of osteoblast proliferation and differentiation
Q24654250Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations
Q34511602Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates
Q53243634High glucose-induced hypertrophy of mesangial cells is reversed by connexin43 overexpression via PTEN/Akt/mTOR signaling.
Q37320406High resolution map of Caenorhabditis elegans gap junction proteins
Q35842812High-resolution proteomic mapping in the vertebrate central nervous system: close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1)
Q46417570Higher susceptibility of spontaneous and NNK-induced lung neoplasms in connexin 43 deficient CD1 × AJ F1 mice: paradoxical expression of connexin 43 during lung carcinogenesis.
Q36368553How do mutations in GJB1 cause X-linked Charcot-Marie-Tooth disease?
Q37442157HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity
Q33614720Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".
Q36661413Human cell responses to ionizing radiation are differentially affected by the expressed connexins.
Q28235511Human connexin26 and connexin30 form functional heteromeric and heterotypic channels
Q50523078Human connexin30.2/31.3 (GJC3) does not form functional gap junction channels but causes enhanced ATP release in HeLa cells.
Q28117683Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system
Q39273628Human diseases associated with connexin mutations.
Q24655300Human oligodendrocytes express Cx31.3: function and interactions with Cx32 mutants
Q41638830Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens
Q24646253Identification and characterization of pannexin expression in the mammalian cochlea
Q34652632Identification and functional analysis of GJA8 mutation in a Chinese family with autosomal dominant perinuclear cataracts
Q44624274Identification of Gap Junction Blockers Using Automated Fluorescence Microscopy Imaging
Q51085102Identifying connexin expression and determining gap junction intercellular communication in rainbow trout cells.
Q41917853Immunohistochemical analysis of connexin43 expression in infertile human testes
Q36890146Impact of Astroglial Connexins on Modafinil Pharmacological Properties
Q48794285Implication of gap junction coupling in amphibian vitellogenin uptake
Q99555728In Vitro Innovation of Tendon Tissue Engineering Strategies
Q50481983In differentiating prefusion myoblasts connexin43 gap junction coupling is upregulated before myoblast alignment then reduced in post-mitotic cells.
Q89960971In silico analyses suggest the cardiac ganglion of the lobster, Homarus americanus, contains a diverse array of putative innexin/innexin-like proteins, including both known and novel members of this protein family
Q43110928In vitro optimization of antisense oligodeoxynucleotide design: an example using the connexin gene family
Q35769933Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer
Q36849388Increasing gap junctional coupling: a tool for dissecting the role of gap junctions
Q36667008Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells
Q47313001Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3.
Q38089731Inherited hearing loss: molecular genetics and diagnostic testing
Q33998166Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways
Q39442549Inhibitors of connexin and pannexin channels as potential therapeutics
Q36951964Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y).
Q92757579Interaction between growing oocytes and granulosa cells in vitro
Q39227398Interactions of Pannexin1 channels with purinergic and NMDA receptor channels
Q36809350Interactions of connexins with other membrane channels and transporters
Q35061520Intercellular redistribution of cAMP underlies selective suppression of cancer cell growth by connexin26.
Q33947209Internal ribosomal entry site (IRES) activity generates endogenous carboxyl-terminal domains of Cx43 and is responsive to hypoxic conditions
Q39347104Intracellular trafficking pathways of Cx43 gap junction channels
Q51347162Investigation of an SPR biosensor for determining the influence of connexin 43 expression on the cytotoxicity of cisplatin.
Q24307764Involvement of PI3K/Akt pathway in TGF-beta2-mediated epithelial mesenchymal transition in human lens epithelial cells
Q47236749Joint diseases: from connexins to gap junctions.
Q37001308Key connexin 43 phosphorylation events regulate the gap junction life cycle
Q30724362Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair
Q28689818Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response
Q24679811Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
Q47726282Levels of gap junction proteins in coronary arterioles and aorta of hamsters exposed to the cold and during hibernation and arousal
Q34906752Lighting up gap junction channels in a flash
Q41947119Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway.
Q90270583Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch
Q47970005Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development
Q42877305Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to carbon or silica-based nanoparticles
Q24682835Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease
Q48840496Loss-of-function and residual channel activity of connexin26 mutations associated with non-syndromic deafness
Q42409098Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: probing mechanisms of autologous stem cell therapy
Q44454865Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells
Q37246555Managing the complexity of communication: regulation of gap junctions by post-translational modification
Q35588574Maternal age effects on myometrial expression of contractile proteins, uterine gene expression, and contractile activity during labor in the rat
Q35208333Mechanism for modulation of gating of connexin26-containing channels by taurine
Q35647366Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium
Q50358017Mechanism of two novel human GJC3 missense mutations in causing non-syndromic hearing loss.
Q55026641Mechanisms of ATP Release by Inflammatory Cells.
Q24683926Methodologies for characterizing phosphoproteins by mass spectrometry
Q38168519Microglia: an active player in the regulation of synaptic activity
Q36379735Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile-associated proteins and ex vivo contractile activity during labour in the rat.
Q42159344Modulation of astrocyte P2Y1 receptors by the carboxyl terminal domain of the gap junction protein Cx43.
Q37270004Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration
Q37973241Modulation of gap junction channels and hemichannels by growth factors.
Q34794839Molecular basis of calcium regulation in connexin-32 hemichannels
Q42618671Molecular cloning and evolutionary analysis of the GJA1 (connexin43) gene from bats (Chiroptera).
Q33194304Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina
Q24303543Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1
Q28569121Molecular dynamics and in vitro analysis of Connexin43: A new 14-3-3 mode-1 interacting protein
Q36507155Molecular genetics of X-linked Charcot-Marie-Tooth disease
Q35958521Molecular interaction and functional regulation of connexin50 gap junctions by calmodulin
Q26865742Motifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensing
Q33375293Mouse lens connexin23 (Gje1) does not form functional gap junction channels but causes enhanced ATP release from HeLa cells
Q92976085Multi-scale approaches for the simulation of cardiac electrophysiology: II - Tissue-level structure and function
Q35890732Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin
Q35609940Multiple neuronal connexins in the mammalian retina
Q85592038Mutant connexin 50 (S276F) inhibits channel and hemichannel functions inducing cataract
Q34329503Mutation R184Q of connexin 26 in hearing loss patients has a dominant-negative effect on connexin 26 and connexin 30
Q40331282Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel
Q34530828Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract
Q62127831Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract
Q36892897Mutational screening of Indian families with hereditary congenital cataract
Q24534074Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease
Q39766622N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26.
Q43225798Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells.
Q35653077Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
Q36493857Neuronal gap junctions: expression, function, and implications for behavior
Q51956086Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes.
Q37732539New insights into the role of connexins in pancreatic islet function and diabetes.
Q28213363New roles for astrocytes: Gap junction hemichannels have something to communicate
Q40352096Non-stationary fluctuation analysis of macroscopic gap junction channel records
Q58194340Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43
Q35557261Novel mechanisms of central nervous system damage in HIV infection.
Q50439331Novel mutations in the connexin43 (GJA1) and GJA1 pseudogene may contribute to nonsyndromic hearing loss.
Q35793548Novel understanding of pathophysiology and potential intervention in acute pancreatitis based on studies of gene-modified mice
Q44357331Oligodendrocyte progenitor enrichment in the connexin32 null-mutant mouse.
Q34169168On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells
Q40360069Opposite regulation of connexin33 and connexin43 by LPS and IL-1alpha in spermatogenesis.
Q55003428Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling.
Q47074111Pannexin 1 ohnologs in the teleost lineage.
Q28592822Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions
Q37104590Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes
Q48410095Pannexin1 is expressed by neurons and glia but does not form functional gap junctions
Q31171198Pannexins are new molecular candidates for assembling gap junctions in the cochlea
Q28567263Pannexins, a family of gap junction proteins expressed in brain
Q38026335Paracrine signaling through plasma membrane hemichannels
Q33691804Pathogenetic role of the deafness-related M34T mutation of Cx26.
Q33959224Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans
Q45014440Patterns of cell-cell coupling in embryonic spinal cord studied via ballistic delivery of gap-junction-permeable dyes
Q37832276Pharmacological modulation of connexin-formed channels in cardiac pathophysiology
Q36936412Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.
Q37032237Phenotypic transformation of smooth muscle cells from porcine coronary arteries is associated with connexin 43
Q48742941Phosphorylation in the C-terminus of the rat connexin46 (rCx46) and regulation of the conducting activity of the formed connexons
Q36980034Phosphorylation of connexin43 induced by Src: regulation of gap junctional communication between transformed cells
Q81595526Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes
Q33856936Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis
Q37485123Potent block of Cx36 and Cx50 gap junction channels by mefloquine
Q36690729Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly
Q46633766Prenylation-defective human connexin32 mutants are normally localized and function equivalently to wild-type connexin32 in myelinating Schwann cells.
Q42683972Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling
Q34645738Properties of connexin 46 hemichannels in dissociated lens fiber cells
Q36836123Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46.
Q36322598Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368.
Q36103931Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.
Q40632684Regulation of Ion Fluxes, Cell Volume and Gap Junctional Coupling by cGMP in GFSHR-17 Granulosa Cells
Q45200618Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia
Q33620254Regulation of gap junction channels by infectious agents and inflammation in the CNS.
Q39142919Regulation of gap junctions in melanoma and their impact on Melan-A/MART-1-specific CD8⁺ T lymphocyte emergence
Q28306001Regulation of renal cell carcinoma cell proliferation, invasion and metastasis by connexin 32 gene
Q47190160Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets.
Q33281114Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart
Q40427070Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells
Q44279112Reversibility of chronic cyclosporine nephropathy in rats after withdrawal of cyclosporine
Q47881008Reversible pore block of connexin channels by cyclodextrins
Q36680668Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathy
Q35031766Role of connexin 43 in Helicobacter pylori VacA-induced cell death.
Q38717394Role of connexin 43 in cadmium-induced proliferation of human prostate epithelial cells.
Q34081156Role of connexin channels in the retinal light response of a diurnal rodent
Q41441785Role of connexin-43 hemichannels in the pathogenesis of Yersinia enterocolitica
Q81078651Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue
Q38162845Role of gap junctions and hemichannels in parasitic infections.
Q37243992Role of gap junctions in embryonic and somatic stem cells
Q40107825Role of the cytoplasmic loop domain of Cx43 in its intracellular localization and function: possible interaction with cadherin
Q36464413Roles of Cx43 and AKAP95 in ovarian cancer tissues in G1/S phase
Q35634085Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress
Q26824488Roles of gap junctions, connexins, and pannexins in epilepsy
Q36404303Screening of gap junction antagonists on dye coupling in the rabbit retina.
Q40337052Selective permeability of different connexin channels to the second messenger cyclic AMP.
Q40560997Sequence and Phylogenetic Analyses of 4 TMS Junctional Proteins of Animals: Connexins, Innexins, Claudins and Occludins
Q44397917Sharp wave-like activity in the hippocampus in vitro in mice lacking the gap junction protein connexin 36.
Q38192647Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load
Q35707998Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation
Q39399257Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells
Q36973512Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes
Q36729097Similarity of the domain structure of proteins as a basis for the conservation of meiosis
Q28550067Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein
Q36445008Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels
Q39245781Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics
Q48673875Spatiotemporal distribution of Connexin45 in the olivocerebellar system
Q48279994Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice
Q37707287Specific Cx43 phosphorylation events regulate gap junction turnover in vivo
Q36712231Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia
Q51893212Stem cells in toxicology: fundamental biology and practical considerations.
Q35012370Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels
Q31044844Subconductance states of Cx30 gap junction channels: data from transfected HeLa cells versus data from a mathematical model
Q34398416Syndromic and non-syndromic disease-linked Cx43 mutations
Q93168864TGF-β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling
Q48064844Tandem alternative splicing of zebrafish connexin45.6.
Q52626070Targeting Gap Junctions: New Insights in the Treatment of Major Depressive Disorder.
Q37046514Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion
Q35566223Temporal regulation of connexin phosphorylation in embryonic and adult tissues
Q35733183Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility
Q41892381Tetracycline-regulated expression enables purification and functional analysis of recombinant connexin channels from mammalian cells
Q28543083Tetramethylpyrazine suppresses transient oxygen-glucose deprivation-induced connexin32 expression and cell apoptosis via the ERK1/2 and p38 MAPK pathway in cultured hippocampal neurons
Q36902136The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking.
Q48183758The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice
Q37075368The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates
Q48114969The Role of Gap Junction-Mediated Endothelial Cell-Cell Interaction in the Crosstalk between Inflammation and Blood Coagulation.
Q57207105The Structural Context of Disease-causing Mutations in Gap Junctions
Q39884960The TSG101 protein binds to connexins and is involved in connexin degradation.
Q28396757The adverse cardiac effects of Di(2-ethylhexyl)phthalate and Bisphenol A
Q38756624The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43.
Q62556275The astrocytic syncytium
Q86061544The carboxy-terminal domain of connexin 43 (CT-Cx43) modulates the expression of p53 by altering miR-125b expression in low-grade human breast cancers
Q43143798The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium
Q52841380The connexin gene family in mammals.
Q35629419The connexin43 carboxyl terminus and cardiac gap junction organization
Q40367325The detection of hamster connexins: a comparison of expression profiles with wild-type mouse and the cancer-prone Min mouse
Q36052992The diverse functional roles and regulation of neuronal gap junctions in the retina.
Q24603834The effects of connexin phosphorylation on gap junctional communication
Q34678350The gap junction as a "Biological Rosetta Stone": implications of evolution, stem cells to homeostatic regulation of health and disease in the Barker hypothesis
Q36500579The gap junction cellular internet: connexin hemichannels enter the signalling limelight
Q35578676The genetic bases for syndromic and nonsyndromic deafness among Jews
Q52663041The impact of caffeine on connexin expression in the embryonic chick cardiomyocyte micromass culture system.
Q43088000The liver connexin32 interactome is a novel plasma membrane-mitochondrial signaling nexus.
Q30913735The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins.
Q39130684The oligodendroglial precursor cell line Oli-neu represents a cell culture system to examine functional expression of the mouse gap junction gene connexin29 (Cx29).
Q35875599The role of altered cell-cell communication in melanoma progression
Q39647999The role of amino terminus of mouse Cx50 in determining transjunctional voltage-dependent gating and unitary conductance
Q40343666The role of connexins in the differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor
Q53809193The role of gap junctions in Charcot-Marie-Tooth disease.
Q37137584The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation
Q35125833The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina
Q92975668The role of oligodendrocyte gap junctions in neuroinflammation
Q36667280The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing
Q50969431Transient upregulation of connexin43 gap junctions and synchronized cell cycle control precede myoblast fusion in regenerating skeletal muscle in vivo.
Q40542422Transport and function of cx26 mutants involved in skin and deafness disorders.
Q35837081Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32
Q39092645Tuning Collective Cell Migration by Cell-Cell Junction Regulation.
Q64947261Two de novo GJA1 mutation in two sporadic patients with erythrokeratodermia variabilis et progressiva.
Q52584179Two distinct heterotypic channels mediate gap junction coupling between astrocyte and oligodendrocyte connexins.
Q21261384Two novel connexin32 mutations cause early onset X-linked Charcot-Marie-Tooth disease
Q36893648Ubiquitination of gap junction proteins
Q41758796Understanding of the molecular evolution of deafness-associated pathogenic mutations of connexin 26.
Q30474526Unmyelinated auditory type I spiral ganglion neurons in congenic Ly5.1 mice
Q61480435Whole-genome sequencing reveals a recurrent missense mutation in the Connexin 46 (GJA3) gene causing autosomal-dominant lamellar cataract
Q37188598X-linked Charcot-Marie-Tooth disease
Q34148181Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion

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