Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus

scientific article published on January 2016

Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BPJ.2015.10.054
P932PMC publication ID4805864
P698PubMed publication ID26745416

P2093author name stringJanis M Burt
Tasha K Pontifex
José F Ek Vitorín
P2860cites workFunctional role of the carboxyl terminal domain of human connexin 50 in gap junctional channelsQ24654049
Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structureQ27009167
Structure of the connexin 26 gap junction channel at 3.5 A resolutionQ27654539
Asymmetric Configurations and N-terminal Rearrangements in Connexin26 Gap Junction ChannelsQ27666014
Permeability and gating properties of human connexins 26 and 30 expressed in HeLa cellsQ28206633
Regulation of connexin43 protein complexes by intracellular acidificationQ28579373
Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40Q28584221
Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop regionQ28909772
Emerging issues of connexin channels: biophysics fills the gap.Q30167614
Structure and functional studies of N-terminal Cx43 mutants linked to oculodentodigital dysplasiaQ30419343
Conductance of connexin hemichannels segregates with the first transmembrane segmentQ30476801
Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylationQ30478921
Hindered diffusion through an aqueous pore describes invariant dye selectivity of Cx43 junctionsQ30481026
Identification of a novel peptide that interferes with the chemical regulation of connexin43.Q33243179
Single-channel events and gating behavior of the cardiac gap junction channelQ33573865
Exchange of conductance and gating properties between gap junction hemichannelsQ33865061
Two distinct gating mechanisms in gap junction channels: CO2-sensitive and voltage-sensitiveQ33915425
Intracellular domains of mouse connexin26 and -30 affect diffusional and electrical properties of gap junction channelsQ33952503
PH regulation of connexin43: molecular analysis of the gating particleQ34040519
A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail lengthQ34092433
Structural and functional diversity of connexin genes in the mouse and human genomeQ34137753
Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32Q34174229
Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43Q34176322
Exchange of gating properties between rat cx46 and chicken cx45.6.Q34187324
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinaseQ34463403
Phosphorylation of connexin 50 by protein kinase A enhances gap junction and hemichannel functionQ34947770
Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heartQ35039192
A functional channel is necessary for growth suppression by Cx37.Q35071530
Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cellsQ35076932
Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channelsQ35128938
Mechanism for modulation of gating of connexin26-containing channels by taurineQ35208333
Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamicsQ35503280
Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recoveryQ35564784
Gap junctions and the connexin protein familyQ35749952
Structural bases for the chemical regulation of Connexin43 channelsQ35749965
Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibuleQ35830244
Voltage-dependent conformational changes in connexin channelsQ36007904
Structural basis for the selective permeability of channels made of communicating junction proteinsQ36074842
Adequate connexin-mediated coupling is required for proper insulin productionQ36236262
Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communicationQ36328306
Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transferQ36410895
Monovalent cation permeation through the connexin40 gap junction channel. Cs, Rb, K, Na, Li, TEA, TMA, TBA, and effects of anions Br, Cl, F, acetate, aspartate, glutamate, and NO3.Q36416091
Extracellular loop cysteine mutant of cx37 fails to suppress proliferation of rat insulinoma cellsQ36480939
Structure-activity relations of the cardiac gap junction channelQ36559690
Molecular basis of voltage dependence of connexin channels: an integrative appraisalQ36807026
Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore densityQ36857040
Connexin 37 profoundly slows cell cycle progression in rat insulinoma cellsQ36977647
The N-terminal half of the connexin protein contains the core elements of the pore and voltage gatesQ37075368
Effects of phosphorylation on the structure and backbone dynamics of the intrinsically disordered connexin43 C-terminal domainQ37112753
The carboxyl terminal residues 220-283 are not required for voltage gating of a chimeric connexin32 hemichannelQ37204358
Regulation of gap junctional charge selectivity in cells coexpressing connexin 40 and connexin 43.Q37264411
The N terminus of connexin37 contains an alpha-helix that is required for channel function.Q37339083
Carboxy terminus and pore-forming domain properties specific to Cx37 are necessary for Cx37-mediated suppression of insulinoma cell proliferationQ37439721
Specific Cx43 phosphorylation events regulate gap junction turnover in vivoQ37707287
Structural and functional studies of gap junction channelsQ37764588
Structure and closure of connexin gap junction channelsQ38184784
The role of amino terminus of mouse Cx50 in determining transjunctional voltage-dependent gating and unitary conductanceQ39647999
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activityQ39679630
Role of the N-terminus in permeability of chicken connexin45.6 gap junctional channelsQ40239792
An amino-terminal lysine residue of rat connexin40 that is required for spermine blockQ40352039
Quantification of gap junction selectivityQ40386619
Alteration of Cx43:Cx40 expression ratio in A7r5 cellsQ40828159
Functional expression and biophysical properties of polymorphic variants of the human gap junction protein connexin37.Q40867256
Connections with connexins: the molecular basis of direct intercellular signalingQ41006464
Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37.Q41081214
Structure of connexin43 and its regulation by pHi.Q41568555
Structural studies of N-terminal mutants of connexin 32 using (1)H NMR spectroscopyQ41892577
Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctionsQ42053547
Structure of the amino terminus of a gap junction proteinQ42635668
Role of the carboxyl terminal of connexin43 in transjunctional fast voltage gatingQ42671777
Dual functions for connexins: Cx43 regulates growth independently of gap junction formationQ42823532
pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domainsQ44085071
Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactionsQ44812355
Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctionsQ44859209
Functional differences between human Cx37 polymorphic hemichannelsQ46149428
Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasiaQ46535683
A particle-receptor model for the insulin-induced closure of connexin43 channelsQ47817475
Connexin diversity and gap junction regulation by pHi.Q48922364
Chimeric evidence for a role of the connexin cytoplasmic loop in gap junction channel gatingQ49014719
The carboxyl terminal domain regulates the unitary conductance and voltage dependence of connexin40 gap junction channels.Q50716462
Volatile anesthetics block intercellular communication between neonatal rat myocardial cells.Q51749593
Characterization of the pH-dependent Interaction between the Gap Junction Protein Connexin43 Carboxyl Terminus and Cytoplasmic Loop DomainsQ59241282
Uncoupling of cardiac cells by doxyl stearic acids specificity and mechanism of actionQ69060548
Uncoupling of cardiac cells by fatty acids: structure-activity relationshipsQ70116887
Electrophysiological properties of gap junction channels in hepatocytes isolated from connexin32-deficient and wild-type miceQ77885651
pH-dependent channel gating in connexin26 hemichannels involves conformational changes in N-terminusQ83347950
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages14
P304page(s)127-140
P577publication date2016-01-01
P1433published inBiophysical JournalQ2032955
P1476titleDeterminants of Cx43 Channel Gating and Permeation: The Amino Terminus
P478volume110

Reverse relations

cites work (P2860)
Q92662494Calmodulin-Mediated Regulation of Gap Junction Channels
Q54977104Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus.
Q37493164Mechanism of gating by calcium in connexin hemichannels
Q38619204Regulation of Cx37 channel and growth suppressive properties by phosphorylation.
Q38862310Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia
Q36374252The NH2 terminus regulates voltage-dependent gating of CALHM ion channels
Q90365645The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening

Search more.