The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates

scientific article published on 24 July 2012

The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00232-012-9457-Z
P932PMC publication ID3735448
P698PubMed publication ID22825713

P2093author name stringVytas K Verselis
Miduturu Srinivas
Jack Kronengold
P2860cites workCross-presentation by intercellular peptide transfer through gap junctions.Q40451404
Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannelQ42649575
Role of the carboxyl terminal of connexin43 in transjunctional fast voltage gatingQ42671777
Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes.Q48735734
Opposite voltage gating polarities of two closely related connexinsQ49110748
Selectivity of connexin-specific gap junctions does not correlate with channel conductance.Q52204658
Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells.Q52212887
GJB2mutations in keratitis-ichthyosis-deafness syndrome including its fatal formQ57637012
Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctionsQ59212248
Substituted-cysteine accessibility methodQ77121562
Structure of the connexin 26 gap junction channel at 3.5 A resolutionQ27654539
Gating properties of gap junction channels assembled from connexin43 and connexin43 fused with green fluorescent proteinQ28367650
Emerging issues of connexin channels: biophysics fills the gap.Q30167614
Conductance of connexin hemichannels segregates with the first transmembrane segmentQ30476801
Post-translational modifications of connexin26 revealed by mass spectrometryQ33506159
Identification of a pore lining segment in gap junction hemichannels.Q33915360
Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndromeQ33950693
Structural and functional diversity of connexin genes in the mouse and human genomeQ34137753
The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctionsQ34170537
Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32Q34174229
The first extracellular loop domain is a major determinant of charge selectivity in connexin46 channelsQ34174541
The permeability of gap junction channels to probes of different size is dependent on connexin composition and permeant-pore affinitiesQ34186774
Exchange of gating properties between rat cx46 and chicken cx45.6.Q34187324
Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channelsQ34189343
Gap junctions: new tools, new answers, new questionsQ34778703
Formation of the gap junction nexus: binding partners for connexinsQ35006304
Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannelsQ35012370
Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamicsQ35503280
Gap junction channel gatingQ35700096
Selective permeability of gap junction channelsQ35700130
Pore-lining residues identified by single channel SCAM studies in Cx46 hemichannelsQ35892064
Identification of amino acid residues lining the pore of a gap junction channelQ36323688
Kinetic properties of a voltage-dependent junctional conductanceQ36408444
Equilibrium properties of a voltage-dependent junctional conductance.Q36408460
Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannelsQ36445008
The gap junction cellular internet: connexin hemichannels enter the signalling limelightQ36500579
Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domainQ37094208
Voltage gating and permeation in a gap junction hemichannelQ37558064
Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70Q40241212
P433issue8
P921main subjectvoltageQ25428
P1104number of pages11
P304page(s)453-463
P577publication date2012-07-24
P1433published inJournal of Membrane BiologyQ6295550
P1476titleThe N-terminal half of the connexin protein contains the core elements of the pore and voltage gates
P478volume245

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cites work (P2860)
Q27002992Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss
Q41946636Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine
Q42021715Carbon Monoxide Modulates Connexin Function through a Lipid Peroxidation-Dependent Process: A Hypothesis
Q34774559Carbon monoxide (CO) is a novel inhibitor of connexin hemichannels
Q38511008Carbon monoxide: A new player in the redox regulation of connexin hemichannels.
Q42183057Characterization of a novel water pocket inside the human Cx26 hemichannel structure
Q42408378Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.
Q21129235Connexin and Pannexin hemichannels are regulated by redox potential
Q38099907Connexin channel modulators and their mechanisms of action
Q50057056Connexin hemichannels and cochlear function
Q38805573Determinants of Cx43 Channel Gating and Permeation: The Amino Terminus
Q38910519Extracellular Cysteine in Connexins: Role as Redox Sensors.
Q26829380Functional analysis and regulation of purified connexin hemichannels
Q37575363Functional effects of Cx50 mutations associated with congenital cataracts.
Q38175394Functional roles of the amino terminal domain in determining biophysical properties of Cx50 gap junction channels
Q37493164Mechanism of gating by calcium in connexin hemichannels
Q38263990Mind the gap: connexins and cell-cell communication in the diabetic kidney.
Q26865742Motifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensing
Q37199244Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?
Q47689866Permeant-specific gating of connexin 30 hemichannels
Q36836123Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46.
Q37158482Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation
Q48611494Role of amino terminus in voltage gating and junctional rectification of Shaking B innexins
Q34398416Syndromic and non-syndromic disease-linked Cx43 mutations
Q89673846The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition
Q93181485The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions

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