Connexin channel modulators and their mechanisms of action

scientific article published on 15 April 2013

Connexin channel modulators and their mechanisms of action is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2013.03.020
P932PMC publication ID3775990
P698PubMed publication ID23597508

P2093author name stringVytas K Verselis
Miduturu Srinivas
P2860cites workQuinine blocks specific gap junction channel subtypesQ24555201
Calcium block of Na+ channels and its effect on closing rateQ24646976
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressantQ24675998
Gap junctions in inherited human disorders of the central nervous systemQ26823332
Structure of the connexin 26 gap junction channel at 3.5 A resolutionQ27654539
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseasesQ28267180
Ionic blockade of the rat connexin40 gap junction channel by large tetraalkylammonium ionsQ28365137
Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cellsQ28573218
Tales of a Dirty Drug: Carbenoxolone, Gap Junctions, and SeizuresQ28972313
Emerging issues of connexin channels: biophysics fills the gap.Q30167614
The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndromeQ30428153
Two distinct gating mechanisms in gap junction channels: CO2-sensitive and voltage-sensitiveQ33915425
Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndromeQ33950693
Hemichannel and junctional properties of connexin 50.Q34177646
Voltage-dependent blockade of connexin40 gap junctions by spermineQ34180081
Effect of external magnesium and calcium on human connexin46 hemichannelsQ34180119
Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channelsQ34189343
Triarylmethanes, a new class of cx50 inhibitorsQ34299455
Human connexin channel specificity of classical and new gap junction inhibitorsQ34333979
Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB).Q34567249
Prospects for rational development of pharmacological gap junction channel blockersQ35007602
The antimalarial agent mefloquine inhibits ATP-sensitive K-channelsQ35042825
The combinatorial synthesis of bicyclic privileged structures or privileged substructures.Q35083549
Electrical coupling and excitatory synaptic transmission between rhythmogenic respiratory neurons in the preBötzinger complexQ35111858
Mechanism for modulation of gating of connexin26-containing channels by taurineQ35208333
Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamicsQ35503280
Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininiumQ35647366
Selective optimization of side activities: another way for drug discoveryQ35681235
Gap junction channel gatingQ35700096
Pore-lining residues identified by single channel SCAM studies in Cx46 hemichannelsQ35892064
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamideQ36057140
Lens gap junctions in growth, differentiation, and homeostasis.Q36233134
Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?Q36282330
Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia.Q36300072
How do mutations in GJB1 cause X-linked Charcot-Marie-Tooth disease?Q36368553
Kinetic properties of a voltage-dependent junctional conductanceQ36408444
Equilibrium properties of a voltage-dependent junctional conductance.Q36408460
The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapyQ36409372
Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytesQ36435171
Structure-activity relations of the cardiac gap junction channelQ36559690
Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gatingQ36843197
Remodelling of gap junctions and connexin expression in diseased myocardium.Q36870641
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevationQ36870663
P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signalingQ36981083
The N-terminal half of the connexin protein contains the core elements of the pore and voltage gatesQ37075368
Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domainQ37094208
Gap junction-mimetic peptides do work, but in unexpected waysQ37130224
Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannelQ37268155
Direct actions of carbenoxolone on synaptic transmission and neuronal membrane propertiesQ37298719
Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studiesQ37375210
GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotypeQ37429017
Potent block of Cx36 and Cx50 gap junction channels by mefloquineQ37485123
Voltage gating and permeation in a gap junction hemichannelQ37558064
Connexin-26 mutations in deafness and skin disease.Q37638797
Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous systemQ37644993
Connexin Modulators and Their Potential Targets under the Magnifying GlassQ37799642
Role of gap junctions in epilepsyQ37959793
Glial hemichannels and their involvement in aging and neurodegenerative diseasesQ38002385
Cisplatin and oxaliplatin inhibit gap junctional communication by direct action and by reduction of connexin expression, thereby counteracting cytotoxic efficacyQ39730206
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes.Q40457389
Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells.Q40598414
Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cellsQ40632649
Besides affecting intracellular calcium signaling, 2-APB reversibly blocks gap junctional coupling in confluent monolayers, thereby allowing measurement of single-cell membrane currents in undissociated cellsQ40665591
Fenamates: a novel class of reversible gap junction blockers.Q40786159
Long-chain n-alkanols and arachidonic acid interfere with the Vm-sensitive gating mechanism of gap junction channelsQ41068020
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.Q41131251
Permeation pathway of homomeric connexin 26 and connexin 30 channels investigated by molecular dynamicsQ41432409
Interaction of anaesthetics with electrical synapsesQ41548926
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant AxonsQ41761074
Analysis of effects of connexin-mimetic peptides in rat mesenteric small arteriesQ42489777
Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannelQ42649575
Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG.Q43740375
Inhibition of gap junction hemichannels by chloride channel blockersQ43916372
Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26.Q44277434
Reversible inhibition of intercellular junctional communication by glycyrrhetinic acidQ44325495
Closure of gap junction channels by arylaminobenzoatesQ44449947
Carbenoxolone Blockade of Neuronal Network Activity in Culture is not Mediated by an Action on Gap JunctionsQ44599998
Identification of Gap Junction Blockers Using Automated Fluorescence Microscopy ImagingQ44624274
Carbenoxolone inhibition of voltage-gated Ca channels and synaptic transmission in the retinaQ44804029
A high-throughput assay for connexin 43 (Cx43, GJA1) gap junctions using codon-optimized aequorinQ45309031
Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationshipsQ46979453
Reversible pore block of connexin channels by cyclodextrinsQ47881008
Opposite voltage gating polarities of two closely related connexinsQ49110748
Severe neuropathy with leaky connexin32 hemichannels.Q50663082
Volatile anesthetics block intercellular communication between neonatal rat myocardial cells.Q51749593
2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32.Q53589060
Gap Junction Hemichannel Interactions with Zwitterionic Lipid, Anionic Lipid, and Cholesterol: Molecular Simulation StudiesQ60713726
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonistsQ69843588
Effect of several uncouplers of cell-to-cell communication on gap junction morphology in mammalian heartQ71833680
Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cellsQ72988595
Cell-cell communication in heterocellular cultures of alveolar epithelial cellsQ73396905
The role of gap junctions in seizuresQ73635204
Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteriesQ73677467
Inhibition of volume-regulated and calcium-activated chloride channels by the antimalarial mefloquineQ74326616
Role of heterocellular Gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: inhibition by a connexin-mimetic peptideQ77911549
Is connexin36 critical for GABAergic hypersynchronization in the hippocampus?Q83386446
Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channelsQ83618373
Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell couplingQ84094747
P1104number of pages8
P304page(s)517-524
P577publication date2013-04-15
P1433published inNeuropharmacologyQ15332439
P1476titleConnexin channel modulators and their mechanisms of action
P478volume75

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cites work (P2860)
Q37724410A Cell-Based Assay to Assess Hemichannel Function
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Q30557012A rapid and sensitive assay of intercellular coupling by voltage imaging of gap junction networks
Q41946636Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine
Q42057370Connexin hemichannels influence genetically determined inflammatory and hyperproliferative skin diseases.
Q55174378Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury.
Q47770967Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications
Q35832943Critical role of gap junction communication, calcium and nitric oxide signaling in bystander responses to focal photodynamic injury.
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Q49047593Electroporation Loading and Dye Transfer: A Safe and Robust Method to Probe Gap Junctional Coupling.
Q57189470Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells
Q33921091Extensive astrocyte synchronization advances neuronal coupling in slow wave activity in vivo
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Q34138968Innexin AGAP001476 is critical for mediating anti-Plasmodium responses in Anopheles mosquitoes
Q47215575Molecular basis for potentiation of Cx36 gap junction channel conductance by n-alcohols and general anesthetics
Q42323019On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells
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Q28550067Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein
Q39154696Synchrony and so much more: Diverse roles for electrical synapses in neural circuits
Q34528370The Role of the Mucosa in Normal and Abnormal Bladder Function
Q90365645The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening
Q41415423The double life of connexin channels: single is a treat

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