The Role of Gap Junction-Mediated Endothelial Cell-Cell Interaction in the Crosstalk between Inflammation and Blood Coagulation.

scientific article

The Role of Gap Junction-Mediated Endothelial Cell-Cell Interaction in the Crosstalk between Inflammation and Blood Coagulation. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/IJMS18112254
P932PMC publication ID5713224
P698PubMed publication ID29077057

P50authorTakayuki OkamotoQ89750375
P2093author name stringKoji Suzuki
P2860cites workAdventitia and perivascular cellsQ26800364
Thrombin and vascular inflammationQ28246124
Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cellsQ28272977
Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migrationQ28508256
Connexin 37 limits thrombus propensity by downregulating platelet reactivity.Q45990622
Molecular role of Cx37 in advanced atherosclerosis: a micro-array studyQ46061439
Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes.Q50281724
Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine-, ERK1/2-, PKA-, and PKC-dependent manner.Q51097534
Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C.Q51774070
Connexin32 is expressed in vascular endothelial cells and participates in gap-junction intercellular communication.Q51781433
Expression of connexin43 gap junctions between cultured vascular smooth muscle cells is dependent upon phenotype.Q52227487
Endothelial connexin 32 regulates tissue factor expression induced by inflammatory stimulation and direct cell-cell interaction with activated cells.Q53461190
Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigrationQ58619840
Unitary permeability of gap junction channels to second messengers measured by FRET microscopyQ58863419
CD73/Ecto-5′-Nucleotidase Protects Against Vascular Inflammation and Neointima FormationQ61612314
Thrombin-induced chemotaxis and aggregation of neutrophilsQ69593060
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in ratsQ70884416
Gap junction localization and connexin expression in cytochemically identified endothelial cells of arterial tissueQ73248772
Regional differentiation of desmin, connexin43, and connexin45 expression patterns in rat aortic smooth muscleQ73570845
Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activationQ74557629
Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributedQ77315013
Multiple connexins form gap junction channels in rat basilar artery smooth muscle cellsQ77866214
Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migrationQ78785487
Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classesQ81595526
Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cellsQ81937265
Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in menQ82689615
Thrombin-induced ATP release from human umbilical vein endothelial cellsQ82899716
Connexins in atherosclerosisQ84171802
Connexin 43 expression is associated with vascular activation in human radial arteryQ84799530
Editorial Commentary: Tissue factor expression by the endothelium: Coagulation or inflammation?Q87239595
LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulinQ89140608
Structure of gap junction intercellular channelsQ41052924
Cx47 fine-tunes the handling of serum lipids but is dispensable for lymphatic vascular functionQ41090229
Gap junction-mediated regulation of endothelial cellular stiffnessQ41094488
Cellular interactions in hemostasisQ41198987
Mechanisms of increased endothelial permeabilityQ41245969
Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta.Q42476351
Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylationQ42583454
Thrombomodulin: a bifunctional modulator of inflammation and coagulation in sepsisQ42589170
Nonmuscle myosin light-chain kinase deficiency attenuates atherosclerosis in apolipoprotein E-deficient mice via reduced endothelial barrier dysfunction and monocyte migrationQ42811392
Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesionQ43212308
Altered pattern of vascular connexin expression in atherosclerotic plaquesQ43880556
Lipopolysaccharide-induced reductions in cellular coupling correlate with tyrosine phosphorylation of connexin 43.Q44183311
TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responsesQ44285411
Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient miceQ44324625
Connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cellsQ44763050
Prediction of the risk of myocardial infarction from polymorphisms in candidate genesQ45857137
Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cellsQ45886047
Connexin40 is essential for the pressure control of renin synthesis and secretionQ28589707
The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1.Q30159462
Regulation of cellular communication by signaling microdomains in the blood vessel wallQ30406156
Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injuryQ30443089
Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivoQ30465475
Recombinant human activated protein C inhibits integrin-mediated neutrophil migrationQ30487220
Gap junction intercellular communication during lymphocyte transendothelial migrationQ30703122
c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytesQ31465510
Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells.Q33524750
The many faces of tissue factorQ33711050
Gap junction protein connexin43 exacerbates lung vascular permeabilityQ33812506
Structural and functional diversity of connexin genes in the mouse and human genomeQ34137753
Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.Q34243239
Connexins and cell signaling in development and diseaseQ34357394
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivationQ34380698
Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activationQ34407634
Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term.Q34462119
Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation?Q34585829
Effects of Morphology vs. Cell-Cell Interactions on Endothelial Cell StiffnessQ34602126
Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contractionQ35164276
Plasma membrane channels formed by connexins: their regulation and functions.Q35541877
Gap junctions and the connexin protein familyQ35749952
Gap junctions and connexin-interacting proteinsQ35749955
Gap junction alterations in human cardiac disease.Q35750004
Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibuleQ35830244
Gap junctional communication between vascular cells. Induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions.Q35832287
Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release.Q35878244
Role of inflammatory mediators in angiogenesis.Q36048112
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphateQ36118459
Protease-activated receptors in hemostasis, thrombosis and vascular biologyQ36230881
The interactions between inflammation and coagulationQ36310877
Regulation of connexin expressionQ36344530
Connexins in atherosclerosisQ36463271
Thrombin-cofactor interactions: structural insights into regulatory mechanismsQ36489906
Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cellsQ36557140
Connexin channel permeability to cytoplasmic moleculesQ36807032
Mechanisms of anticoagulant and cytoprotective actions of the protein C pathwayQ37019583
Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activationQ37066759
Protease-activated receptors in hemostasisQ37097085
Connexin40 regulates platelet functionQ37250478
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.Q37331775
Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathwaysQ37343990
Macrophage diversity and polarization in atherosclerosis: a question of balanceQ37583322
An intact connexin43 is required to enhance signaling and gene expression in osteoblast-like cellsQ37657917
Inflammation and coagulationQ37677466
The endothelium: physiological functions and role in microcirculatory failure during severe sepsisQ37742508
von Willebrand factor and the endotheliumQ37750499
Connexin channel-dependent signaling pathways in inflammation.Q37798402
Role of connexins in microvascular dysfunction during inflammationQ37824131
Thrombomodulin and its role in inflammation.Q37909178
Can gap junctions deliver?Q37944055
Endothelial membrane reorganization during leukocyte extravasationQ38008939
Structure and closure of connexin gap junction channelsQ38184784
Between Rho(k) and a hard place: the relation between vessel wall stiffness, endothelial contractility, and cardiovascular diseaseQ38365775
Extracellular ATP metabolism on vascular endothelial cells: A pathway with pro-thrombotic and anti-thrombotic molecules.Q38491295
Platelets and physics: How platelets "feel" and respond to their mechanical microenvironmentQ38500982
Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis.Q38502107
Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration.Q38532856
Collective cell migration: guidance principles and hierarchiesQ38542134
Structural basis of blocking integrin activation and deactivation for anti-inflammationQ38543641
The role of ecto-5'-nucleotidase in endothelial dysfunction and vascular pathologiesQ38576785
Gap junctional shuttling of miRNA--A novel pathway of intercellular gene regulation and its prospects in clinical applicationQ38590638
Thrombin promotes diet-induced obesity through fibrin-driven inflammationQ38665177
The eNOS signalosome and its link to endothelial dysfunction.Q38835675
Gap junctions modulate glioma invasion by direct transfer of microRNAQ38874498
Next-Generation Connexin and Pannexin Cell BiologyQ38875571
Connexin37 protects against atherosclerosis by regulating monocyte adhesionQ40252212
Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell lineQ40863608
Selective transfer of endogenous metabolites through gap junctions composed of different connexinsQ40916863
The gap junction communication channelQ40974984
Acute loss of cell-cell communication caused by G protein-coupled receptors: a critical role for c-SrcQ41051004
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
blood coagulationQ179217
Cell–cell interactionQ5058397
cellQ7868
cell communicationQ14860133
P577publication date2017-10-27
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleThe Role of Gap Junction-Mediated Endothelial Cell-Cell Interaction in the Crosstalk between Inflammation and Blood Coagulation
P478volume18

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