Thrombin and vascular inflammation

scientific article (publication date: 2012)

Thrombin and vascular inflammation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1004392972
P356DOI10.1007/S11010-011-1024-X
P3181OpenCitations bibliographic resource ID4862753
P698PubMed publication ID21858738
P5875ResearchGate publication ID51587538

P50authorKatarina SmiljanicQ59668063
Tatiana SyrovetsQ64212708
P2093author name stringThomas Simmet
Esma R Isenović
Milan Popović
Branislava Dobutović
P2860cites workInducible secretion of large, biologically potent von Willebrand factor multimersQ24296142
cPLA2 is phosphorylated and activated by MAP kinaseQ24314148
Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaqueQ24339425
Activation of human factor IX (Christmas factor)Q24594116
Src family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human plateletsQ28183746
The role of PAR4 in thrombin-induced thromboxane production in human plateletsQ28190619
Prostaglandins, bioassay and inflammationQ28194428
P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activationQ28194880
Intravascular tissue factor pathway--a model for rapid initiation of coagulation within the blood vesselQ28204622
Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregationQ28211291
Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140Q28237622
Role of tissue factor in hemostasis, thrombosis, and vascular developmentQ28259220
Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cellsQ28262222
A dual thrombin receptor system for platelet activationQ28280578
The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of actionQ28298065
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitmentQ28298072
Functional prothrombinase complex assembly on isolated monocytes and lymphocytesQ71766776
EndothelinsQ71874242
Persistent activation of coagulation mechanism in unstable angina and myocardial infarctionQ72047945
Role of thrombin in endothelial cell monolayer repair in vitroQ72734000
Anticoagulant properties of the vascular endotheliumQ73145742
Wear of enhanced ultra-high molecular-weight polyethylene (Hylamer) in combination with a 22.225 mm diameter zirconia femoral headQ73347452
Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulationQ73445675
Polymorphonuclear leukocytes modulate tissue factor production by mononuclear cells: role of reactive oxygen speciesQ73567365
Increased plasma tissue factor levels in acute myocardial infarctionQ73739624
Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in plateletsQ73811661
Thrombin-induced thromboxane synthesis by human platelets. Properties of anion binding exosite I-independent receptorQ74070965
Platelet-endothelial interactions in inflamed mesenteric venulesQ74138198
Tissue factor: an enzyme cofactor and a true receptorQ74315010
The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombinQ74481626
Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cellsQ77148291
Activated platelets and endothelial cell interaction with neutrophils under flow conditionsQ77391112
Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophilsQ77760114
Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable anginaQ77846342
Distinct calcium-dependent pathways of epidermal growth factor receptor transactivation and PYK2 tyrosine phosphorylation in PC12 cellsQ78010436
Platelet P-selectin facilitates atherosclerotic lesion developmentQ78654773
Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cellsQ79086335
Elimination of platelet factor 4 (PF4) from platelets reduces atherosclerosis in C57Bl/6 and apoE-/- miceQ79828506
Role of superoxide dismutase in vascular inflammation and in coronary artery diseaseQ79840041
Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wallQ80512468
Structure and function of the plasminogen/plasmin systemQ81668319
High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cellsQ82920543
Human platelets target dendritic cell differentiation and production of proinflammatory cytokinesQ83314817
Relation of platelet count to bleeding and vascular complications in patients undergoing coronary angiographyQ84077201
Fibrinolysis: the key to new pathogenetic mechanisms.Q37160777
Blood-borne tissue factor: another view of thrombosisQ37181879
Protease-activated receptors as targets for antiplatelet therapyQ37223084
Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forcesQ37352056
Endothelial-mural cell signaling in vascular development and angiogenesisQ37375745
Protease-activated receptors in cardiovascular health and diseasesQ37382716
B-type natriuretic peptide: endogenous regulator of myocardial structure, biomarker and therapeutic targetQ37622311
The lipoprotein-associated coagulation inhibitorQ37677766
VEGF-A: a critical regulator of blood vessel growthQ37694868
Involvement of ERK1/2 kinase in insulin-and thrombin-stimulated vascular smooth muscle cell proliferationQ37715560
Signaling by members of the TGF-beta family in vascular morphogenesis and diseaseQ37775374
Insulin, thrombine, ERK1/2 kinase and vascular smooth muscle cells proliferation.Q37821037
Thromboxane A2: its generation and role in platelet activationQ38263211
Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1.Q38289775
Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact plateletsQ38306581
The mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cellsQ39699871
Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cellQ39706389
Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migrationQ39988367
The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 releaseQ40014591
Natural anticoagulant mechanismsQ40143046
Endothelial-leukocyte adhesion molecules in human diseaseQ40389501
Long-term aspirin in the prevention of cardiovascular disorders. Recent developments and variations on a themeQ40423093
Interleukin-6 exacerbates early atherosclerosis in miceQ40793841
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factorQ40867206
Vascular endothelial cell activation and permeability responses to thrombinQ40946084
Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.Q40956616
Restenosis following percutaneous revascularization--the potential role of thrombin and the thrombin receptorQ41148508
Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cellsQ41508649
Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cellsQ41585571
Endothelial cells in physiology and in the pathophysiology of vascular disordersQ41757874
The protease-activated receptors and their cellular expression and function in blood-related cellsQ41759322
Simultaneous expression of tissue factor and tissue factor pathway inhibitor by human monocytes. A potential mechanism for localized control of blood coagulationQ41780031
Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.Q41835663
Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivoQ42044945
Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactionsQ42101310
Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cellsQ42320997
Electromagnetic fields inhibit endothelin-1 production stimulated by thrombin in endothelial cellsQ42485252
Thrombin-stimulated elevation of human endothelial-cell cytoplasmic free calcium concentration causes prostacyclin productionQ42516679
Regulation of proteinase-activated receptor 1 by inflammatory mediators in human vascular endothelial cellsQ42524907
Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions.Q42821507
Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human plateletsQ42983397
Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V.Q42987531
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic miceQ43489161
Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathwayQ43559449
Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib.Q43562682
The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitmentQ43684711
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.Q43720106
Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxinQ43770098
Modulation of angiogenesis and progelatinase a by thrombin receptor mimetics and antagonistsQ43874428
Molecular analysis of axon repulsion by the notochordQ44304860
Inhibition of the MEK/ERK pathway has no effect on agonist-induced aggregation of human plateletsQ44403188
Inhibition of Platelet-Activating Factor (PAF) Acetylhydrolase by Methyl Arachidonyl Fluorophosphonate Potentiates PAF Synthesis in Thrombin-Stimulated Human Coronary Artery Endothelial CellsQ44618356
Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation.Q44714830
Structural and functional properties of human alpha-thrombin, phosphopyridoxylated alpha-thrombin, and gamma T-thrombin. Identification of lysyl residues in alpha-thrombin that are critical for heparin and fibrin(ogen) interactionsQ44844257
Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-AktQ45029420
Regulation of thrombomodulin expression in human vascular smooth muscle cells by COX-2-derived prostaglandinsQ45182845
Role of p38 mitogen-activated protein kinase in thrombus formationQ45222435
Thrombin stimulates smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardinQ45278736
Endothelial cells for studies of platelet-activating factor and arachidonate metabolitesQ45743099
Restoration of plasma von Willebrand factor deficiency is sufficient to correct thrombus formation after gene therapy for severe von Willebrand diseaseQ45878422
Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells.Q45968786
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.Q46001763
Thrombin regulates matrix metalloproteinase-9 expression in human monocytes.Q46005207
Primary and secondary capture of platelets onto inflamed femoral artery endothelium is dependent on P-selectin and PSGL-1.Q46014527
Basic and translational research on proteinase-activated receptors: antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic diseaseQ46189242
Thrombin-stimulated proliferation of cultured human synovial fibroblasts through proteolytic activation of proteinase-activated receptor-1.Q46372583
Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cellsQ28581725
Tissue factor and hemostasisQ28630773
Human blood coagulation factor IX. Purification, properties, and mechanism of activation by activated factor XIQ28631030
Elements of the fibrinolytic systemQ28645802
Immunobiology of dendritic cellsQ29547465
Adhesion receptors of the immune systemQ29616393
Leukotrienes and lipoxins: structures, biosynthesis, and biological effectsQ29617543
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversityQ29617967
Thrombin signalling and protease-activated receptorsQ29619601
Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbitsQ30468424
Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosisQ30469144
Platelet functions beyond hemostasisQ33385887
Inflammation, sepsis, and coagulationQ33585742
Molecular mechanisms that control leukocyte extravasation: the selectins and the chemokines.Q33720042
How the protease thrombin talks to cellsQ33740137
Native fibrin gel networks and factors influencing their formation in health and disease.Q33811728
Impaired fibrinolysis in the antiphospholipid syndromeQ33822542
Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.Q33900013
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectinQ34056920
NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis.Q34074465
Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signalingQ34108989
P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagenQ34150092
Minding the gaps to promote thrombus growth and stabilityQ34160242
Tissue factor, the blood, and the arterial wallQ34175576
Megakaryocytes and beyond: the birth of plateletsQ34215516
Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptorsQ34251521
The platelet release reaction: granules' constituents, secretion and functionsQ34327198
The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3‐kinase pathway in maintaining thrombin‐induced platelet aggregationQ34342288
Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclinQ34407094
Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cellsQ34518795
Molecular mechanisms of thrombin-induced endothelial cell permeabilityQ34527539
Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially releasedQ34584213
Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cellsQ34621520
VEGF-A and the induction of pathological angiogenesisQ34718259
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activityQ34775047
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesisQ34828549
Heterogeneous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary arteryQ35042191
G-protein coupled receptor antagonists-1: protease activated receptor-1 (PAR-1) antagonists as novel cardiovascular therapeutic agentsQ35137619
Biochemistry of Nitric Oxide and Its Redox-Activated FormsQ35159350
Dendritic cells in peripheral tolerance and immunity.Q35219314
Development of Proteinase-Activated Receptor 1 Antagonists as Therapeutic Agents for Thrombosis, Restenosis and Inflammatory DiseasesQ35551904
The role of the membrane in the expression of the vitamin K-dependent enzymesQ35564112
Regulation of leukocyte transmigration: cell surface interactions and signaling eventsQ35612622
Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytesQ35682957
Reactive oxygen species in vascular biology: role in arterial hypertensionQ35696507
Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerizationQ35720592
P-selectin induces the expression of tissue factor on monocytesQ35746146
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokinesQ35749970
Bidirectional relation between inflammation and coagulationQ35796641
Signalling through the platelet glycoprotein Ib-V-IX complexQ35894162
Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cellsQ36220406
Protease-activated receptors in hemostasis, thrombosis and vascular biologyQ36230881
Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombinQ36270379
Platelets and blood vessels: the adhesion eventQ36286236
The interaction of thrombin with blood plateletsQ36291249
The interactions between inflammation and coagulationQ36310877
Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cellsQ36436399
Accelerated atherogenesis and neointima formation in heparin cofactor II deficient miceQ36447954
Assembly, activation, and physiologic influence of the plasma kallikrein/kinin systemQ36492944
Dendritic cells: translating innate to adaptive immunity.Q36627111
Leucocyte cellular adhesion moleculesQ36633473
Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathwaysQ36647303
The roles of proteinase-activated receptors in the vascular physiology and pathophysiology.Q36649442
Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesisQ36660105
Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in miceQ36853413
The FGF system has a key role in regulating vascular integrityQ36861249
Platelet activation and atherothrombosisQ37031278
Platelet chemokines in vascular diseaseQ37131719
Mature dendritic cells express functional thrombin receptors triggering chemotaxis and CCL18/pulmonary and activation-regulated chemokine induction.Q46497438
Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humansQ46614700
Transcriptional inhibition of protease-activated receptor-1 expression by prostacyclin in human vascular smooth muscle cells.Q46830533
Thrombin regulates the function of human blood dendritic cellsQ46940799
The size of human factor VIII heterodimers and the effects produced by thrombinQ47207667
Mechanism of endothelium-dependent relaxation induced by thrombin in the pig coronary arteryQ47711198
Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cellsQ47835116
Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectinQ47869831
Recombinant human inhibin-A administered early in the menstrual cycle alters concurrent pituitary and follicular, plus subsequent luteal, function in rhesus monkeysQ48877475
Maturity and fertility of rhesus monkey oocytes collected at different intervals after an ovulatory stimulus (human chorionic gonadotropin) in in vitro fertilization cyclesQ49026420
Selective recruitment of neutrophils and lymphocytes by thrombin: a role for NF-kappaB.Q49227852
Protease-activated receptors upregulate cyclooxygenase-2 expression in human endothelial cells.Q50281727
Platelet response heterogeneity in thrombus formation.Q50284450
Thrombin binding to GPIbalpha induces platelet aggregation and fibrin clot retraction supported by resting alphaIIbbeta3 interaction with polymerized fibrinQ50331347
Comparison of plasma tissue factor levels in unstable and stable angina pectoris.Q50908719
Proliferation of dental pulp fibroblasts in response to thrombin involves mitogen-activated protein kinase signalling.Q51052801
Myeloid blood CD11c(+) dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes.Q52114386
The role of the tissue factor pathway in initiation of coagulation.Q52231388
Platelet factor Xa receptorQ52434023
Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs.Q52507277
Mechanism of endothelial nitric oxide synthase phosphorylation and activation by thrombin.Q53578656
Thrombin induces EGF receptor expression and cell proliferation via a PKC(delta)/c-Src-dependent pathway in vascular smooth muscle cells.Q54730744
Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular InjuryQ56944225
Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood PlateletsQ59057847
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditionsQ59064735
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent plateletsQ59065667
Direct Vascular Effects of Protease-Activated Receptor Type 1 Agonism In Vivo in HumansQ63488636
Time course of recovery of endothelial cell surface thrombin receptor (PAR-1) expression.Q64960495
The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activityQ67469084
Thrombin-catalyzed activation of single chain bovine factor VQ67469113
Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitroQ67913706
Functional difference between intrinsic and extrinsic coagulation pathways. Kinetics of factor X activation on human monocytes and alveolar macrophagesQ67987137
Thrombin enhances release of tissue plasminogen activator from bovine corneal endothelial cellsQ69212170
Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cellsQ69535502
Thrombin-induced chemotaxis and aggregation of neutrophilsQ69593060
Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activityQ69843451
A pathway of coagulation on endothelial cellsQ69874615
Endothelium and the regulation of coagulationQ70015651
Human prothrombinase complex assembly and function on isolated peripheral blood cell populationsQ70060804
Subunit structure of thrombin-activated human factor VIIIaQ70372881
Proliferation of microvascular endothelial cells in the primate corpus luteum during the menstrual cycle and simulated early pregnancyQ70824082
Macrophages and neutrophils infiltrating into the liver are responsible for tissue factor expression in a rabbit model of acute obstructive cholangitisQ71307865
Monocyte chemotaxis: stimulation by specific exosite region in thrombinQ71695951
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)301-313
P577publication date2011-08-23
P1433published inMolecular and Cellular BiochemistryQ1573176
P1476titleThrombin and vascular inflammation
P478volume359

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