Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes (scientific article published on August 1994)

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

Q28266921

Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity

Q28288965

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes

Q28294180

Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes

Q28300093

Thrombin is a potent mitogen for rat astroblasts but not for oligodendroblasts and neuroblasts in primary culture

Q48244943

Morphological and biochemical alterations in foetal rat brain cells cultured in the presence of monobutyryl cyclic AMP.

Q48687304

Resistance and susceptibility of neural cells to lysis by cytotoxic lymphocytes and by cytolytic granules.

Q54263278

Thrombin reverts the beta-adrenergic agonist-induced morphological response in rat glioma C6 cells.

Q55484503

Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis

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Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

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Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

Q67486053

Weighing naked proteins: practical, high-accuracy mass measurement of peptides and proteins

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Specific interaction of vitronectin with the cell-secreted protease inhibitor glia-derived nexin and its thrombin complex

Q67672206

In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C

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Evidence for the involvement of a T-cell-associated serine protease (TSP-1) in cell killing

Q68169088

A family of serine esterases in lytic granules of cytolytic T lymphocytes

Q68956731

Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes

Q69871030

The role of cytoplasmic granule components in cytolytic lymphocyte-mediated cytolysis

Q70348026

Hydrolysis of myelin basic protein in myelin membranes by granzymes of large granular lymphocytes

Q72072942

Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic Lesions

Q72773066

Characterization and isolation of a trypsin-like serine protease from a long-term culture cytolytic T cell line and its expression by functionally distinct T cells

Q28336899

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Q28594763

Thrombin modulates and reverses neuroblastoma neurite outgrowth

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Autocrine growth and progression of murine X-ray-induced T cell lymphomas.

Q33880155

Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides

Q33923228

Homology of perforin to the ninth component of complement (C9).

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Identification of a monoclonal antibody specific for a murine T3 polypeptide

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Apoptosis and programmed cell death in immunity

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A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis

Q36229747

Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis

Q36351457

Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes

Q36353869

Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation

Q36445887

A central role of perforin in cytolysis?

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Perforin-mediated target cell lysis by cytolytic T lymphocytes

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The T lymphocyte in experimental allergic encephalomyelitis

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Structure and function of perforin

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The cytolytic T lymphocyte and its mode of action

Q38625956

Cellular and humoral mechanisms of cytotoxicity: structural and functional analogies

Q39465247

Regulation of thrombin generation and functions

Q39530343

Neuron-glia interrelations.

Q39552007

The role of cytoplasmic granules in lymphocyte cytotoxicity

Q39634751

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

Q40153639

Neurite outgrowth activity of protease nexin-1 on neuroblastoma cells requires thrombin inhibition

Q41223116

Appearance of cytolytic granules upon induction of cytolytic activity in CTL-hybrids

Q41419855

Simultaneous analysis of adenosine 3',5'-cyclic monophosphate accumulation and adenosine 5'-triphosphate metabolism in cultured cells preincubated with [2-3H]adenine

Q41608588

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers

Q41617636

Cell specificity of granzyme gene expression

Q41716167

Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro

Q41733207

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes

Q42941532

T helper cell cytoplasmic granules. Exocytosis in response to activation via the T cell receptor

Q45004573

Protease nexin-1 complexes and inhibits T cell serine proteinase-1.

Q45612167

cDNA clones from autocrine thymic lymphoma cells encode two mitogenic proteins, a serine protease and a truncated T-cell receptor beta-chain

Q45804062

Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

Q46128784

Domains specifying thrombin–receptor interaction

Q46311150

Immunization with synthetic peptides containing a defined malaria epitope induces a highly diverse cytotoxic T lymphocyte response. Evidence that two peptide residues are buried in the MHC molecule

Q47858925

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

cytotoxicity

Q246181

astrocyte

Q502961

P304

page(s)

8112-8116

P577

publication date

1994-08-01

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

P478

volume

Reverse relations

cites work (P2860)

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P819	ADS bibcode	1994PNAS...91.8112S
P356	DOI	10.1073/PNAS.91.17.8112
P932	PMC publication ID	44555
P698	PubMed publication ID	8058766
P5875	ResearchGate publication ID	15140014