RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border

scientific article published on 2 May 2016

RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.201504038
P932PMC publication ID4862328
P698PubMed publication ID27138256

P50authorAnne RidleyQ21254312
Miguel A AlonsoQ42873532
Beatriz Marcos RamiroQ42889592
María Cristina OrtegaQ55507147
Diego García-WeberQ58762241
Jaime MillánQ58762250
Isabel CorreasQ64877222
Mari Carmen DuranQ73589772
Susan CoxQ86718705
Jorge FeitoQ89370544
P2093author name stringLaura Fernández-Martín
Natalia Reglero-Real
Eva Cernuda-Morollón
Susana Barroso
P2860cites workFarnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPaseQ24298206
Rocks: multifunctional kinases in cell behaviourQ24303641
MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expressionQ24306882
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangementQ24671831
Rac activation by the T-cell receptor inhibits T cell migrationQ27320959
Thrombin and vascular inflammationQ28246124
Why three Rho proteins? RhoA, RhoB, RhoC, and cell motilityQ28289336
Multiple sclerosisQ28299151
The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathwayQ28472131
Inflammation in atherosclerosisQ29547428
Activation of Rac and Cdc42 by integrins mediates cell spreadingQ29616113
Dynasore, a cell-permeable inhibitor of dynaminQ29619881
Adherens junctions connect stress fibres between adjacent endothelial cellsQ30493870
Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.Q30539318
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcriptionQ30560112
ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrityQ30564169
Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interactionQ30612918
The role of endothelial function and its assessment in rheumatoid arthritis.Q33547329
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.Q33591096
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.Q33751705
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPasesQ33772643
A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cellsQ34260840
Haemostatic system in inflammatory bowel diseases: new players in gut inflammation.Q34579752
RhoB and the mammalian Diaphanous-related formin mDia2 in endosome traffickingQ34596684
RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac.Q34819874
Is thrombin a key player in the 'coagulation-atherogenesis' maze?Q34948467
The small GTPase RhoB regulates TNFα signaling in endothelial cellsQ35005344
Rho GTPases and the regulation of endothelial permeabilityQ35127959
RhoA and RhoC have distinct roles in migration and invasion by acting through different targetsQ35196063
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.Q35377560
Bidirectional relation between inflammation and coagulationQ35796641
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodelingQ35839771
Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migrationQ36043664
RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cellsQ36285714
Intertwining of thrombosis and inflammation in atherosclerosisQ36667645
Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulationQ36956180
Dual regulation of endothelial junctional permeabilityQ37000246
TNF-mediated inflammatory disease.Q37045764
Regulation of endothelial junctional permeabilityQ37122803
Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier functionQ37170755
On the use of Ripley's K-function and its derivatives to analyze domain sizeQ37303919
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudilQ37450106
RhoA, RhoB and RhoC have different roles in cancer cell migrationQ38089140
cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier- a signaling pathway compromised in inflammationQ38169904
Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organsQ38906960
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migrationQ39963386
RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1.Q40412034
Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeabilityQ40519304
Differential regulation of human lung epithelial and endothelial barrier function by thrombinQ40530274
Thrombin and tumor necrosis factor alpha synergistically stimulate tissue factor expression in human endothelial cells: regulation through c-Fos and c-JunQ40544635
Retrieval of TGN proteins from the cell surface requires endosomal acidification.Q40791910
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane trafficQ41659144
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxiaQ42143470
Apicobasal polarity controls lymphocyte adhesion to hepatic epithelial cells.Q42186565
Involvement of Rho kinase in endothelial barrier maintenanceQ42518129
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membraneQ42823071
Rho and Rac but not Cdc42 regulate endothelial cell permeability.Q43546609
Synergistic effects of tumor necrosis factor-alpha and thrombin in increasing endothelial permeabilityQ43737991
Multiple sclerosis clinical course and cardiovascular disease risk - Swedish cohort studyQ44567736
Driving Rho GTPase activity in endothelial cells regulates barrier integrity.Q50276491
HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway.Q52578361
Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function.Q52626707
TNF-induced endothelial barrier disruption: beyond actin and Rho.Q52652490
Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1.Q53308318
Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: role of protein kinases, calcium, and RhoA.Q54115091
Roles of Rho/ROCK and MLCK in TNF-α-induced changes in endothelial morphology and permeabilityQ57909944
Increased thrombin generation in inflammatory bowel diseasesQ84904272
Recycling endosomesQ85236652
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P1104number of pages18
P304page(s)385-402
P577publication date2016-05-02
P1433published inJournal of Cell BiologyQ1524550
P1476titleRhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border
P478volume213

Reverse relations

cites work (P2860)
Q40062087A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.
Q47447773A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome
Q92589094Building Blood Vessels-One Rho GTPase at a Time
Q64979602CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity.
Q61800494Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells
Q47727869Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis
Q39365296Endothelial cell-cell adhesion and signaling
Q38807317Filling the Void: Proximity-Based Labeling of Proteins in Living Cells.
Q42373419Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation.
Q58804980KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration
Q39148245Mind the gap: mechanisms regulating the endothelial barrier
Q92409391Multifaceted Rho GTPase Signaling at the Endomembranes
Q55309370Parallels between single cell migration and barrier formation: The case of RhoB and Rac1 trafficking.
Q51456781RHOB expression controls the activity of serine/threonine protein phosphatase PP2A to modulate mesenchymal phenotype and invasion in non-small cell lung cancers.
Q48286660RhoA, RhoB and RhoC differentially regulate endothelial barrier function.
Q49550467RhoB: Team Oncogene or Team Tumor Suppressor?
Q48191911The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.
Q39016646The RhoB small GTPase in physiology and disease
Q60308057The precise molecular signals that control endothelial cell-cell adhesion within the vessel wall
Q90028175Transcriptomic analysis of differential gene expression during chick periocular neural crest differentiation into corneal cells

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