Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function

scientific article published on 18 February 2020

Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1917295117
P932PMC publication ID7060683
P698PubMed publication ID32071217

P50authorJoAnn TrejoQ61742920
Jacob M WozniakQ89766697
Olivia Molinar-InglisQ89766699
P2093author name stringYing Lin
David J Gonzalez
Neil J Grimsey
Thomas H Smith
John D Lapek
Anand Patwardhan
Sravan Girada
P2860cites workAdducin: structure, function and regulationQ24290117
Activation of endothelial cell protease activated receptor 1 by the protein C pathwayQ24299215
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationQ24337851
Thrombin and vascular inflammationQ28246124
The multifunctional GIT family of proteinsQ28306026
NetworKIN: a resource for exploring cellular phosphorylation networksQ30002344
Binding to F-actin guides cadherin cluster assembly, stability, and movementQ30538260
Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X.Q30562515
STEM: a tool for the analysis of short time series gene expression dataQ31036195
Role of G protein-coupled receptors in inflammation.Q33858841
Signal transduction by protease-activated receptorsQ33870369
Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.Q33900013
Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiologyQ34998535
Activated protein C: biased for translation.Q35583397
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffoldsQ35647525
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cellsQ35669786
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodelingQ35839771
Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferationQ36024090
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomesQ36102747
Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.Q36147000
Protease-activated receptors in hemostasis, thrombosis and vascular biologyQ36230881
Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesisQ36316682
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.Q36509665
Vascular permeability in cardiovascular disease and cancerQ37129687
Caveolae are required for protease-selective signaling by protease-activated receptor-1.Q37159069
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activityQ37217154
The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implicationsQ37393194
A novel significance score for gene selection and ranking.Q37642326
Regulation of endothelial permeability via paracellular and transcellular transport pathwaysQ37690727
VE-cadherin and endothelial adherens junctions: active guardians of vascular integrityQ38138649
Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cellsQ40338912
Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombinQ42146853
Single-step enrichment by Ti4+-IMAC and label-free quantitation enables in-depth monitoring of phosphorylation dynamics with high reproducibility and temporal resolution.Q42229898
Broken barriers: a new take on sepsis pathogenesis.Q43492938
Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivationQ45264873
A role for thrombin receptor signaling in endothelial cells during embryonic developmentQ46345481
Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signalingQ46866239
Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities.Q47823611
Cellular and molecular regulation of vascular permeability.Q50760843
Using the scan-x Web site to predict protein post-translational modifications.Q52731755
p38 MAP kinase-dependent regulation of endothelial cell permeabilityQ54964218
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory SignalingQ58721218
β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in strokeQ61799899
Activated protein C, protease activated receptor 1, and neuroprotectionQ88984497
Illuminating the dark phosphoproteomeQ91167984
P433issue9
P304page(s)5039-5048
P577publication date2020-02-18
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePhosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function
P478volume117