Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells

scientific journal article

Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPCELL.00284.2005
P698PubMed publication ID16148030

P50authorNagadhara DronadulaQ124980778
P2093author name stringHuiqing Cao
Gadiparthi N. Rao
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ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cellsQ28581381
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Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesisQ35169865
Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer CellsQ35749110
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cellsQ36321986
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxisQ36322960
NADPH oxidase mediates tissue factor-dependent surface procoagulant activity by thrombin in human vascular smooth muscle cellsQ38289755
JunB forms the majority of the AP-1 complex and is a target for redox regulation by receptor tyrosine kinase and G protein-coupled receptor agonists in smooth muscle cellsQ38327919
Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survivalQ39446473
Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptorsQ39700439
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.Q40020748
FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells.Q40479143
S100B increases proliferation in PC12 neuronal cells and reduces their responsiveness to nerve growth factor via Akt activation.Q40486252
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signalingQ40540364
Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletionQ40578104
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factorQ40867206
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptorsQ41229236
Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migrationQ41668247
Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.Q42796335
Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathwayQ42827804
Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathwayQ43559449
Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cellsQ43666441
Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathwaysQ43961145
Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cellsQ44352642
Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cellsQ44690020
Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathwaysQ45136853
STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motilityQ45153426
Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathwaysQ45195875
Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is importantQ45216903
Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery modelQ45245048
Prolonged thrombin inhibition reduces restenosis after balloon angioplasty in porcine coronary arteries.Q52529435
Syndecan-4 Is Required for Thrombin-induced Migration and Proliferation in Human Vascular Smooth Muscle CellsQ57372313
Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle CellsQ57908184
P433issue1
P304page(s)C172–182
P577publication date2006-01-01
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleThrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells
P478volume290

Reverse relations

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