Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation

scientific article published on 15 July 2014

Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1079079897
P356DOI10.1186/1475-2840-13-105
P932PMC publication ID4223716
P698PubMed publication ID25927959

P2093author name stringWei Zhang
James T Willerson
Mehran Haidari
Richard Af Dixon
P2860cites workPlasminogen Activator System in Human Coronary AtherosclerosisQ72049373
High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alphaQ73670345
Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activationQ73787446
Induction of vascular SMC proliferation by urokinase indicates a novel mechanism of action in vasoproliferative disordersQ73965851
Myosin phosphatase regulatory pathways: different functions or redundant functions?Q79494361
Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptorQ85036980
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actinQ42459171
Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?Q42474709
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signalingQ42478267
Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.Q42708500
cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.Q43142737
A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic ratsQ43192650
PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunctionQ43712800
VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptorQ44320701
Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activationQ44776652
Glucose-induced transmigration of monocytes is linked to phosphorylation of PECAM-1 in cultured endothelial cellsQ46222270
High glucose-induced human umbilical vein endothelial cell hyperpermeability is dependent on protein kinase C activation and independent of the Ca2+-nitric oxide signalling pathwayQ46712828
The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cellsQ47859760
Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells.Q47977873
Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP.Q52531493
Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation.Q52626028
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeabilityQ24634777
Regulation of cell motility by mitogen-activated protein kinaseQ24678874
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-cateninQ27631714
From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesionQ28256172
Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agentsQ28478705
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryosQ28619032
Inflammation in atherosclerosisQ29547428
Convergence of Wnt, beta-catenin, and cadherin pathwaysQ29619504
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective mannerQ30304130
p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylationQ30483820
Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin poolsQ33411752
Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissuesQ33556970
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.Q33751705
Myosin light chain kinase in microvascular endothelial barrier functionQ33954983
Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosisQ36228893
Integrin α2β1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cellsQ36294762
Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques?Q36775094
Current topics in the regulatory mechanism underlying the Ca2+ sensitization of the contractile apparatus in vascular smooth muscleQ36835387
VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formationQ37046356
The role of adherens junctions and VE-cadherin in the control of vascular permeabilityQ37195511
Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitusQ37239783
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesionsQ37486465
Novel insights into leukocyte extravasationQ37991197
Myosin light chain phosphorylation facilitates monocyte transendothelial migration by dissociating endothelial adherens junctionsQ39476023
Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formationQ40308209
Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpainQ41766019
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
phosphorylationQ242736
P304page(s)105
P577publication date2014-07-15
P1433published inCardiovascular DiabetologyQ2468083
P1476titleDisruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation
P478volume13

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cites work (P2860)
Q64229192Astragaloside IV prevents high glucose‑induced cell apoptosis and inflammatory reactions through inhibition of the JNK pathway in human umbilical vein endothelial cells
Q47156232Correction to: Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation
Q28822277Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus
Q37581139Dephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II.
Q43167219Effects of high glucose on human umbilical vein endothelial cell permeability and myosin light chain phosphorylation
Q34324055Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal
Q46059179Endothelial Permeability, Ldl Deposition, and Cardiovascular Risk Factors - A Review.
Q35101210Inhibition of protein kinase C enhances angiogenesis induced by platelet-derived growth factor C in hyperglycemic endothelial cells
Q61817409Phorbol ester-induced angiogenesis of endothelial progenitor cells: The role of NADPH oxidase-mediated, redox-related matrix metalloproteinase pathways
Q26778080Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation
Q58096193Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease)
Q48114969The Role of Gap Junction-Mediated Endothelial Cell-Cell Interaction in the Crosstalk between Inflammation and Blood Coagulation.
Q88985401Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

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