Cardiac connexins and impulse propagation

scientific article published on 31 August 2009

Cardiac connexins and impulse propagation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YJMCC.2009.08.018
P698PubMed publication ID19729017
P5875ResearchGate publication ID48324209

P2093author name stringJacques M T de Bakker
John A Jansen
Harold V M van Rijen
Toon A B van Veen
P2860cites workBasic Mechanisms of Cardiac Impulse Propagation and Associated ArrhythmiasQ22337019
Ligand-activated site-specific recombination in miceQ24600193
Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45.Q24675707
Connexin43: a protein from rat heart homologous to a gap junction protein from liverQ24680192
Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction systemQ28117683
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2Q28295943
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43Q28506915
Gap junction channels formed by coexpressed connexin40 and connexin43Q28576324
Functional properties of mouse connexin30.2 expressed in the conduction system of the heartQ28586647
Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient miceQ28587598
Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic developmentQ28588260
Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch blockQ28588926
Slow ventricular conduction in mice heterozygous for a connexin43 null mutationQ28591559
Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40Q28591560
Heart defects in connexin43-deficient miceQ28592456
A targeted disruption in connexin40 leads to distinct atrioventricular conduction defectsQ28592699
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to agingQ28593454
Gap junction remodeling and altered connexin43 expression in the failing human heartQ73085637
High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction systemQ73178378
Formation of heterotypic gap junction channels by connexins 40 and 43Q73427333
Diversity of gap junctional proteins: does it play a role in cardiac excitation?Q73530346
Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40Q73635736
Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction couplingQ73833055
Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activationQ74211196
Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conductionQ74292476
High resolution optical mapping reveals conduction slowing in connexin43 deficient miceQ74446322
Electrophysiological features of the mouse sinoatrial node in relation to connexin distributionQ74513784
Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heartQ74609476
Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexonsQ74618902
Rapid turnover of connexin43 in the adult rat heartQ77315007
Relative expression of immunolocalized connexins 40 and 43 correlates with human atrial conduction propertiesQ77385016
Connexin45, a major connexin of the rabbit sinoatrial node, is co-expressed with connexin43 in a restricted zone at the nodal-crista terminalis borderQ77901217
Molecular mechanisms of myocardial remodelingQ77918078
Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardiaQ78375776
Up-regulation of connexin45 in heart failureQ79369581
Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atriaQ79984913
Increasing gap junction coupling reduces transmural dispersion of repolarization and prevents torsade de pointes in rabbit LQT3 modelQ80823996
Discontinuous conduction in mouse bundle branches is caused by bundle-branch architectureQ81307969
Hypoxia, electrical uncoupling, and conduction slowing: Role of conduction reserveQ81526269
The effect of enhanced gap junctional conductance on ventricular conduction in explanted hearts from patients with heart failureQ83179289
Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient miceQ28593966
Altered right atrial excitation and propagation in connexin40 knockout miceQ30497043
Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goatQ30888574
Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricleQ32100784
Chamber-related differences in connexin expression in the human heart.Q33862875
Gap junctions in cardiovascular diseaseQ33949000
The sinoatrial node, a heterogeneous pacemaker structureQ34023812
Structural and functional diversity of connexin genes in the mouse and human genomeQ34137753
Remodeling of ventricular conduction pathways in healed canine infarct border zonesQ34187384
Modulation of cardiac gap junction expression and arrhythmic susceptibility.Q34207091
Cardiac myocytes express multiple gap junction proteinsQ34233299
Propagation through electrically coupled cells. How a small SA node drives a large atriumQ34258541
Cardiac gap junction channels: modulation of expression and channel propertiesQ34317993
Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexinsQ34435250
Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular nodeQ34596202
Plasma membrane channels formed by connexins: their regulation and functions.Q35541877
Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissuesQ36220146
The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domainsQ36220893
Mechanisms of atrial fibrillation: lessons from animal models.Q36272316
Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43.Q36459035
Is there a role for remodeled connexins in AF? No simple answersQ36459867
Cardiac connexins: genes to nexus.Q36463222
Connexins and cardiac arrhythmiasQ36463244
Validation of immunohistochemical quantification in confocal scanning laser microscopy: a comparative assessment of gap junction size with confocal and ultrastructural techniques.Q36767353
Multiple connexins colocalize in canine ventricular myocyte gap junctionsQ36771777
Robert Feulgen Prize Lecture. Distribution and role of gap junctions in normal myocardium and human ischaemic heart disease.Q36780969
Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation.Q36788875
New insights into myocardial arrhythmogenesis: distribution of gap-junctional coupling in normal, ischaemic and hypertrophied human heartsQ36806773
Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathyQ36837659
Remodelling of gap junctions and connexin expression in diseased myocardium.Q36870641
Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cellsQ37213790
Incompatibility of connexin 40 and 43 Hemichannels in gap junctions between mammalian cells is determined by intracellular domainsQ37383889
Gap junction protein phenotypes of the human heart and conduction systemQ40970873
Cardiac malformation in neonatal mice lacking connexin43.Q41358695
Freeze-fracture studies of gap junctions in vertebrate cardiac muscle cellsQ41637643
Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cellsQ41665390
Gap junction shape and orientation at the cardiac intercalated diskQ41998307
Protein kinase Calpha mediates the effect of antiarrhythmic peptide on gap junction conductanceQ44027831
Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletionQ44735472
Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout miceQ44932498
Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A.Q45171607
Increased late sodium current in myocytes from a canine heart failure model and from failing human heart.Q45284438
Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heartQ46229481
Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential durationQ46239877
Restricted distribution of connexin40, a gap junctional protein, in mammalian heart.Q46544653
Differential connexin distribution accommodates cardiac function in different speciesQ46690042
Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillationQ46781708
ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs.Q46978294
Heterogeneous expression of connexins in rabbit sinoatrial node cells: correlation between connexin isotype and cell sizeQ47197176
Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growthQ47246756
Architectural and functional asymmetry of the His-Purkinje system of the murine heart.Q47352047
Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosisQ47741490
Relationship between connexins and atrial activation during human atrial fibrillationQ47933334
Hallmarks of ion channel gene expression in end-stage heart failureQ48206560
Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes.Q50710952
Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43.Q51033472
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of CardiologyQ51152117
Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation.Q51469223
Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction.Q51497168
Correlation of connexin43 expression and late ventricular potentials in nonischemic dilated cardiomyopathy.Q51641861
Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice.Q51795127
Gradient model versus mosaic model of the sinoatrial node.Q52069015
Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system.Q52192878
Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system.Q52204502
Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart.Q52236833
Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia.Q52524238
Connexin40-deficient mice exhibit atrioventricular nodal and infra-Hisian conduction abnormalities.Q52541557
Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45.Q53604390
Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling.Q54107288
Localization and distribution of gap junctions in normal and cardiomyopathic hamster heart.Q54192523
Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties.Q54193717
The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents.Q54540195
Activation Delay After Premature Stimulation in Chronically Diseased Human Myocardium Relates to the Architecture of Interstitial FibrosisQ54952239
Ventricular Late Potentials, Interstitial Fibrosis, and Right Ventricular Function in Patients With Ventricular Tachycardia and Normal Left Ventricular FunctionQ57763803
Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mappingQ59241313
Distribution pattern of connexin 43, a gap junctional protein, during the differentiation of mouse heart myocytesQ67507393
Distribution and three-dimensional structure of intercellular junctions in canine myocardiumQ69485568
Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human heartsQ70470418
Spatial distribution of connexin43, the major cardiac gap junction protein, visualizes the cellular network for impulse propagation from sinoatrial node to atriumQ72187817
Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemiaQ73071883
P433issue1
P304page(s)76-82
P577publication date2009-08-31
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleCardiac connexins and impulse propagation
P478volume48