Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

scientific article

Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.E11-12-1058
P932PMC publication ID3431943
P698PubMed publication ID22787277

P50authorEric C. BeyerQ37370738
Carlos F. LagosQ38546932
Tomas Perez-AcleQ43119293
Raul Araya-SecchiQ48358883
P2093author name stringJuan C Sáez
Viviana M Berthoud
Vania Figueroa
Agustín D Martínez
Oscar Jara
Jaime Maripillán
Rodrigo Acuña
Isaac E García
P2860cites workDimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranesQ24324737
Connexin43: a protein from rat heart homologous to a gap junction protein from liverQ24680192
Structure of the connexin 26 gap junction channel at 3.5 A resolutionQ27654539
Domain assembly of NAADP-gated two-pore channelsQ28250269
Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulumQ28564736
Comparative protein structure modeling using ModellerQ29615142
Emerging issues of connexin channels: biophysics fills the gap.Q30167614
Loss-of-function and residual channel activity of connexin26 mutations associated with non-syndromic deafnessQ48840496
Homozygosity for the V37I Connexin 26 mutation in three unrelated children with sensorineural hearing loss.Q50487258
Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene.Q50494656
Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel.Q53605087
Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptorQ73041284
Gating and regulation of connexin 43 (Cx43) hemichannelsQ30480722
Gap-junction channels dysfunction in deafness and hearing lossQ30490087
TOXCAT: a measure of transmembrane helix association in a biological membraneQ31917651
Heteromeric connexons formed by the lens connexins, connexin43 and connexin56.Q32043463
Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.Q33718824
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in cultureQ33898269
Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functionsQ34084948
Structural and functional diversity of connexin genes in the mouse and human genomeQ34137753
Casein kinase 1 regulates connexin-43 gap junction assemblyQ34150954
The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptorsQ34351420
Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamicsQ35503280
Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNAQ35540725
Plasma membrane channels formed by connexins: their regulation and functions.Q35541877
Homo- and hetero-oligomerization of G protein-coupled receptorsQ35579619
Different domains are critical for oligomerization compatibility of different connexins.Q35656804
Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannelsQ36445008
Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannelQ37268155
An aberrant sequence in a connexin46 mutant underlies congenital cataracts.Q37288625
Dimerization and ligand binding affect the structure network of A(2A) adenosine receptorQ37780304
Assembly of nicotinic and other Cys-loop receptorsQ37826784
Structure and mechanism of glutamate receptor ion channel assembly, activation and modulationQ37846960
A modified, dual reporter TOXCAT system for monitoring homodimerization of transmembrane segments of proteinsQ38318639
Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cellsQ40558677
Changes in apparent free energy of helix-helix dimerization in a biological membrane due to point mutationsQ41890424
Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.Q43233958
Assembly of gap junction channels: mechanism, effects of calmodulin antagonists and identification of connexin oligomerization determinantsQ43705169
The single transmembrane domains of ErbB receptors self-associate in cell membranesQ43821697
Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulationQ44011981
Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxinQ44299992
Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43.Q45345951
P4510describes a project that usesImageJQ1659584
P433issue17
P921main subjecttransmembrane proteinQ424204
P304page(s)3299-3311
P577publication date2012-07-11
P1433published inMolecular Biology of the CellQ2338259
P1476titleCritical role of the first transmembrane domain of Cx26 in regulating oligomerization and function
P478volume23

Reverse relations

cites work (P2860)
Q42205663Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations
Q38685620Association between the p.V37I variant of GJB2 and hearing loss: a pedigree and meta-analysis
Q30810767Characterization of a knock-in mouse model of the homozygous p.V37I variant in Gjb2.
Q42183057Characterization of a novel water pocket inside the human Cx26 hemichannel structure
Q58742492Concatenation of Human Connexin26 (hCx26) and Human Connexin46 (hCx46) for the Analysis of Heteromeric Gap Junction Hemichannels and Heterotypic Gap Junction Channels
Q36031035Connexinopathies: a structural and functional glimpse
Q52716310Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.
Q26797404Diseases associated with leaky hemichannels
Q64270584Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere Disease
Q30430702Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells
Q90339565Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation
Q27320878Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43.
Q40698511Newborn genetic screening for hearing impairment: a population-based longitudinal study.
Q34700455Prevalence of p.V37I variant of GJB2 in mild or moderate hearing loss in a pediatric population and the interpretation of its pathogenicity
Q37158482Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation
Q58701520Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome
Q42633335Screening for transmembrane association in divisome proteins using TOXGREEN, a high-throughput variant of the TOXCAT assay
Q37047097Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels

Search more.