Tetravalent antibody-scTRAIL fusion proteins with improved properties

scientific article

Tetravalent antibody-scTRAIL fusion proteins with improved properties is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1186/1476-4598-13-101
P932PMC publication ID4022787
P698PubMed publication ID24092811
P5875ResearchGate publication ID262815124

P50authorRoland E KontermannQ87862266
Klaus PfizenmaierQ91723231
P2093author name stringMartin Siegemund
Oliver Seifert
Aline Plappert
Sina Fellermeier
P2860cites workDifferential protein expressions in renal cell carcinoma: new biomarker discovery by mass spectrometryQ38509519
Exploring the pathogenesis of renal cell carcinoma: pathway and bioinformatics analysis of dysregulated genes and proteinsQ38511517
LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinomaQ39282620
Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinomaQ39296588
GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesisQ39872802
Microvascular density as an independent predictor of clinical outcome in renal cell carcinoma: an automated image analysis studyQ40005099
Quantitative proteomic analysis in metastatic renal cell carcinoma reveals a unique set of proteins with potential prognostic significanceQ42109826
Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesisQ42846581
Expression of nuclear FIH independently predicts overall survival of clear cell renal cell carcinoma patientsQ42937345
Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumorQ44320068
Carbonic anhydrase IX (CAIX) is not an independent predictor of outcome in patients with clear cell renal cell carcinoma (ccRCC) after long-term follow-upQ46234210
Differential expression profiling of microRNAs and their potential involvement in renal cell carcinoma pathogenesis.Q51806979
CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.Q54331256
Exploring the role of miRNAs in renal cell carcinoma progression and metastasis through bioinformatic and experimental analyses.Q54339183
miRNA profiling for clear cell renal cell carcinoma: biomarker discovery and identification of potential controls and consequences of miRNA dysregulation.Q54357850
Towards improved prognostic scores predicting survival in patients with brain metastases: a pilot study of serum lactate dehydrogenase levels.Q55394617
Cancer as a metabolic diseaseQ21245061
Renal tumors: diagnostic and prognostic biomarkersQ26860500
Cancer statistics, 2012Q27860574
Glycolysis inhibition for anticancer treatmentQ28256222
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progressionQ28272474
Why do cancers have high aerobic glycolysis?Q28290710
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenanceQ29620462
Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter studyQ33510317
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancerQ33682182
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma.Q33880227
External validation and comparison with other models of the International Metastatic Renal-Cell Carcinoma Database Consortium prognostic model: a population-based studyQ34086969
Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinomaQ34296301
Searching for the hereditary causes of renal-cell carcinomaQ34318015
Metabolic imaging: a link between lactate dehydrogenase A, lactate, and tumor phenotypeQ34440549
Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinomaQ34533170
Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.Q34554861
Prognostic significance of morphologic parameters in renal cell carcinoma.Q34716073
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancerQ35659640
Genome-wide screening of copy number alterations and LOH events in renal cell carcinomas and integration with gene expression profileQ36477174
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferationQ36907933
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancerQ37165231
MicroRNAs in clinical oncology: at the crossroads between promises and problemsQ37592919
Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapyQ37723006
Alterations in VHL as potential biomarkers in renal-cell carcinomaQ37724576
Cancers with increasing incidence trends in the United States: 1999 through 2008.Q37979107
Interactions between epigenetics and metabolism in cancersQ38060735
Genomic medicine: new frontiers and new challengesQ38071277
Energy management - a critical role in cancer induction?Q38111505
Identification and validation of dysregulated metabolic pathways in metastatic renal cell carcinomaQ38484441
P433issue1
P921main subjectantibodyQ79460
P304page(s)101-111
P577publication date2013-10-03
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleTetravalent antibody-scTRAIL fusion proteins with improved properties
P478volume13

Reverse relations

cites work (P2860)
Q388484832ME2 inhibits the activated hypoxia-inducible pathways by cabozantinib and enhances its efficacy against medullary thyroid carcinoma
Q96303214A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells
Q37696203A four-gene signature predicts survival in clear-cell renal-cell carcinoma
Q28080748Adipose tissue dysfunction and its effects on tumor metabolism
Q41686962Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format.
Q37141627An optimized antibody-single-chain TRAIL fusion protein for cancer therapy.
Q37290538Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer
Q39097822Biomarkers of Renal Tumors: the Current State and Clinical Perspectives
Q39244262Current Role of Renal Biopsy in Urologic Practice
Q92876490Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules
Q40294268Downregulation of VEGFA inhibits proliferation, promotes apoptosis, and suppresses migration and invasion of renal clear cell carcinoma
Q52649685Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Q35590091Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display.
Q37379859Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration
Q33648672HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells
Q54998541IgG-single-chain TRAIL fusion proteins for tumour therapy.
Q64226347Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
Q35571437Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis
Q37448160LDHB may be a significant predictor of poor prognosis in osteosarcoma
Q26766711Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
Q36260554Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer
Q38648029Lactate dehydrogenase and creatine kinase as poor prognostic factors in lung cancer: A retrospective observational study
Q37584289Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma
Q52599425Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses.
Q27723745Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
Q37688151MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A.
Q91716512Molecular Mode of Action of TRAIL Receptor Agonists-Common Principles and Their Translational Exploitation
Q26740187Novel drugs that target the metabolic reprogramming in renal cell cancer
Q38659118Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2.
Q26768160Onto better TRAILs for cancer treatment
Q91839736PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA
Q37641600Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide
Q26796270Principles of antibody-mediated TNF receptor activation
Q36197277Prognostic Value of Serum Lactate Dehydrogenase in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis
Q55456133Prognostic value of D-lactate dehydrogenase in patients with clear cell renal cell carcinoma.
Q37687556Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy.
Q48119782SERPINH1 overexpression in clear cell renal cell carcinoma: association with poor clinical outcome and its potential as a novel prognostic marker
Q55452513Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways.
Q37718064Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival
Q55012569Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells.
Q36605807The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer
Q37683757The miR-383-LDHA axis regulates cell proliferation, invasion and glycolysis in hepatocellular cancer
Q40114063Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
Q37734791Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma
Q37565493miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma