Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival

scientific article published on March 2017

Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.21873/ANTICANRES.11435
P932PMC publication ID5363403
P698PubMed publication ID28314283

P2093author name stringKaram F A Soliman
Hernan Flores-Rozas
Elizabeth A Mazzio
David Bauer
Nzinga Mack
P2860cites workLactate Dehydrogenase B Controls Lysosome Activity and Autophagy in CancerQ28771724
Tetravalent antibody-scTRAIL fusion proteins with improved propertiesQ33619046
A Proteomic Study of Human Merkel Cell CarcinomaQ34274250
1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer CellsQ35409868
Metabolic signature identifies novel targets for drug resistance in multiple myelomaQ35612105
Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor OutcomeQ35962134
Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancerQ36260554
The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancerQ36605807
Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibiting integrin β5-mediated glycolysisQ36958403
Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progressionQ37376527
High-Throughput Screening to Identify Plant Derived Human LDH-A InhibitorsQ37519163
Ablation of CD44 induces glycolysis-to-oxidative phosphorylation transition via modulation of the c-Src-Akt-LKB1-AMPKα pathwayQ38755795
Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcomaQ38766568
Hypoxia-inducible proteins HIF1α and lactate dehydrogenase LDH5, key markers of anaerobic metabolism, relate with stem cell markers and poor post-radiotherapy outcome in bladder cancerQ38783511
Sensitization of hepatocellular carcinoma cells to irradiation by miR‑34a through targeting lactate dehydrogenase‑A.Q38787815
Relationship between 18F-FDG accumulation and lactate dehydrogenase A expression in lung adenocarcinomasQ38945433
Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracilQ38946267
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axisQ38952185
Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapyQ39006199
Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas.Q39229740
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.Q39247409
LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinomaQ39282620
Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinomaQ39473092
Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesisQ39612899
Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell linesQ39713426
Inhibition of LDHA suppresses tumor progression in prostate cancerQ42160926
On the relevance of glycolysis process on brain gliomasQ42649313
Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cellsQ43537462
Development of a high throughput in vitro toxicity screen predictive of high acute in vivo toxic potentialQ43744515
Inhibition of LDHA Deliver Potential Anticancer Performance in Renal Cell Carcinoma.Q52877859
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1205-1212
P577publication date2017-03-01
P1433published inAnticancer ResearchQ326290
P1476titleStable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival
P478volume37

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cites work (P2860)
Q92994088Co-culture With Human Breast Adipocytes Differentially Regulates Protein Abundance in Breast Cancer Cells
Q60950311Cytisine-Pterocarpan-Derived Compounds: Biomimetic Synthesis and Apoptosis-Inducing Activity in Human Breast Cancer Cells
Q92354474Identification and functional characterization of Lys-trimethylation of lactate dehydrogenase A
Q95326270Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy
Q49188115Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs
Q49588503Small interfering RNA-mediated α-enolase knockdown suppresses glycolysis and proliferation of human glioma U251 cells in vitro
Q64902286Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells.

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