The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.

scientific article published on 28 August 2013

The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M112.443093
P932PMC publication ID3798470
P698PubMed publication ID23986435

P50authorTakahiro KodamaQ39402298
Yoshinobu SaitoQ57000258
Satoshi TanakaQ57000274
Tetsuo TakeharaQ89741919
Naoki HiramatsuQ96131050
Tomohide TatsumiQ114433231
Takuya MiyagiQ114433273
P2093author name stringWei Li
Hayato Hikita
Minoru Shigekawa
Satoshi Shimizu
Tatsuya Kanto
Tsukasa Kawaguchi
P2860cites workApoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakQ24296478
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid miceQ28242854
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosisQ28511080
The BCL-2 protein family: opposing activities that mediate cell deathQ29547380
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegalyQ33334800
Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in miceQ33388495
BH3-only proteins in apoptosis and beyond: an overviewQ34085370
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.Q34124538
Mechanisms of lipotoxicity in NAFLD and clinical implicationsQ35132916
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophagesQ35628862
The role of Bcl-2 family members in tumorigenesisQ35680535
Death by association: BH3 domain-only proteins and liver injuryQ36312529
Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liverQ36577819
BH3-only protein bid participates in the Bcl-2 network in healthy liver cellsQ36577830
Bcl-2-regulated apoptosis: mechanism and therapeutic potentialQ36880621
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Q37100016
Mcl-1 degradation during hepatocyte lipoapoptosisQ37431628
BH3-only proteins and their roles in programmed cell deathQ37566201
Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosisQ38336372
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in miceQ39508688
Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.Q39648890
Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosisQ40108223
Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell deathQ40732702
Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury.Q43803789
Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses.Q52560625
Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained.Q52590557
Dual regulation of hepatocyte apoptosis by reactive oxygen species: Increases in transcriptional expression and decreases in proteasomal degradation of BimEL.Q54648649
Expression of Bcl-2 familial proteins is reduced in small bile duct lesions of primary biliary cirrhosisQ73471084
Genotyping the mouse severe combined immunodeficiency mutation using the polymerase chain reaction with confronting two-pair primers (PCR-CTPP)Q74766073
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamiliesQ79370601
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)30009-30018
P577publication date2013-08-28
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver
P478volume288

Reverse relations

cites work (P2860)
Q51768533Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis.
Q34726786Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes
Q26781203Regulation of Bim in Health and Disease
Q37309527Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma

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