Cholesterol effects on BAX pore activation

scientific article published on 20 June 2008

Cholesterol effects on BAX pore activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JMB.2008.06.037
P932PMC publication ID2597564
P698PubMed publication ID18590739
P5875ResearchGate publication ID5262352

P2093author name stringPaul Schlesinger
Eric Christenson
Sean Merlin
Mitsu Saito
P2860cites workApoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakQ24296478
NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived OxysterolsQ24300768
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosisQ24533270
Movement of Bax from the cytosol to mitochondria during apoptosisQ24677881
Oxysterol biosynthetic enzymesQ28139744
Peripheral benzodiazepine receptors and mitochondrial functionQ28201926
Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesisQ28205153
Cell death: critical control pointsQ28240722
Membrane-protein interactions in cell signaling and membrane traffickingQ28248356
Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c releaseQ28579372
VDAC2 inhibits BAK activation and mitochondrial apoptosisQ28594000
The BCL-2 protein family: opposing activities that mediate cell deathQ29547380
Mitochondrial membrane permeabilization in cell deathQ29547425
The pathophysiology of mitochondrial cell deathQ29547893
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosisQ29620466
The voltage dependent anion channel affects mitochondrial cholesterol distribution and functionQ33292291
Cholesterol's interfacial interactions with galactosylceramidesQ33792383
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosisQ33854131
BAX-dependent transport of cytochrome c reconstituted in pure liposomesQ33912996
VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial functionQ33915365
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversionQ33948072
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.Q34139321
Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotypeQ34304761
New insights into the mechanism of permeation through large channelsQ34352427
Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?Q34522154
Liquid-liquid immiscibility in membranesQ35062616
Peeking into a secret world of pore-forming toxins: membrane binding processes studied by surface plasmon resonance.Q35559641
Functional, synthetic organic chemical models of cellular ion channelsQ35690277
The condensing effect of cholesterol in lipid bilayersQ35794510
Cytochrome C-mediated apoptosisQ35799945
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decisionQ35812274
Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporationQ35989488
The enantiomer of cholesterolQ36035615
What's so special about cholesterol?Q36052476
Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.Q36118156
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopyQ36234474
Regulated targeting of BAX to mitochondria.Q36255507
On the role of VDAC in apoptosis: fact and fictionQ36259127
Life in the balance: how BH3-only proteins induce apoptosis.Q36294226
Cholesterol and the interaction of proteins with membrane domains.Q36436022
Surface plasmon resonance in protein-membrane interactionsQ36439282
Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunitiesQ36490192
The Bax pore in liposomes, BiophysicsQ36501189
Ionic strength of the intermembrane space of intact mitochondria as estimated with fluorescein-BSA delivered by low pH fusionQ36529908
Mitochondria as the target of the pro-apoptotic protein Bax.Q36534322
Mitochondrial P450sQ36555033
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.Q36593741
Phase boundaries and biological membranesQ36698591
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranesQ36799170
Bcl-2-regulated apoptosis: mechanism and therapeutic potentialQ36880621
Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).Q39536902
Ion channels in liposomesQ40141536
Mechanisms and genes of cellular suicideQ40605270
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membraneQ40816351
Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cellsQ41844170
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivoQ42529079
The C- and N-Terminal Residues of Synthetic Heptapeptide Ion Channels Influence Transport Efficacy Through Phospholipid BilayersQ42565141
Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondriaQ42597073
Phosphatidylcholine acyl unsaturation modulates the decrease in interfacial elasticity induced by cholesterolQ42928959
Energetics and partition of two cecropin-melittin hybrid peptides to model membranes of different compositionQ43062959
Morphological correlates of functionally defined synaptic vesicle populationsQ43558103
Enantiospecificity of cholesterol function in vivoQ43764671
Exploring peptide membrane interaction using surface plasmon resonance: differentiation between pore formation versus membrane disruption by lytic peptidesQ44276478
The role of cytochrome c diffusion in mitochondrial electron transportQ44529460
Trojan horse-like behavior of a biologically representative mixture of oxysterolsQ44819905
Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptorQ45140597
Distinct domains control the addressing and the insertion of Bax into mitochondria.Q45182291
Properties of nonfused liposomes immobilized on an L1 Biacore chip and their permeabilization by a eukaryotic pore-forming toxinQ46615466
Enantiospecific interactions between cholesterol and phospholipidsQ46826245
Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranesQ46847162
Changes in specific lipids regulate BAX-induced mitochondrial permeability transitionQ46889586
How might you compare mitochondria from different tissues and different species?Q46891171
Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC).Q50113362
The effect of melittin on proliferation and death of thymocytes.Q50527919
Characterization of the surfaces generated by liposome binding to the modified dextran matrix of a surface plasmon resonance sensor chip.Q51604331
Colorimetric determination of phospholipids with ammonium ferrothiocyanateQ56453315
Sterol and pH Interdependence in the Binding, Oligomerization, and Pore Formation of Listeriolysin O†Q57365087
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblastsQ60056610
The mitochondrial channel VDAC has a cation-selective open stateQ63027354
The properties of mitochondria enriched in vitro with cholesterolQ68606951
Cholesterol and phospholipid composition of mitochondria and microsomes isolated from morris hepatoma 5123 and rat liverQ68666774
Mitochondrial cholesterol content and membrane properties in porcine myocardial ischemiaQ70567457
Role of lipid transfer proteins in the abnormal lipid content of Morris hepatoma mitochondria and microsomesQ71733380
Motional dynamics of functional cytochrome c delivered by low pH fusion into the intermembrane space of intact mitochondriaQ72960267
Quantitative studies on the melittin-induced leakage mechanism of lipid vesiclesQ74252243
Standardizing the free energy change of transmembrane helix-helix interactionsQ78376983
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamiliesQ79370601
Cell biology. Cellular demolition and the rules of engagementQ79750370
Intracellular cholesterol transportQ80059619
Voltage gating of VDAC is regulated by nonlamellar lipids of mitochondrial membranesQ80312005
Utilization of intramitochondrial membrane cholesterol by cytochrome P-450-dependent cholesterol side-chain cleavage reaction in bovine adrenocortical mitochondria: steroidogenic and non-steroidogenic pools of cholesterol in the mitochondrial innerQ93573314
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1168-1183
P577publication date2008-06-20
P1433published inJournal of Molecular BiologyQ925779
P1476titleCholesterol effects on BAX pore activation
P478volume381

Reverse relations

cites work (P2860)
Q38432040A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.
Q27002044BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore
Q43289014Bax distribution into mitochondrial detergent-resistant microdomains is related to ceramide and cholesterol content in postischemic hearts
Q28240923Bioactive lipids and the control of Bax pro-apoptotic activity
Q37705156Cholesterol and ion channels
Q37433219Detergent-activated BAX protein is a monomer
Q36438467Effect of Cholesterol on the Structure of a Five-Component Mitochondria-Like Phospholipid Membrane.
Q35165455Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.
Q41579498Mitochondrial outer membrane permeabilization: a focus on the role of mitochondrial membrane structural organization
Q37328406Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth
Q37778022Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins
Q41975085Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process
Q42153822The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading
Q34198892The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression
Q38668186The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane
Q36150746The dynamics of Bax channel formation: influence of ionic strength
Q37138526The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes
Q36985116Three-dimensional structure of Bax-mediated pores in membrane bilayers
Q37356591ent-Steroids: novel tools for studies of signaling pathways

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