Tirofiban counteracts endothelial cell apoptosis through the VEGF/VEGFR2/pAkt axis.

scientific article

Tirofiban counteracts endothelial cell apoptosis through the VEGF/VEGFR2/pAkt axis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VPH.2015.12.001
P698PubMed publication ID26699078

P50authorGiuseppe Biondi-ZoccaiQ50743631
P2093author name stringSimona Romano
Maria Fiammetta Romano
Arturo Giordano
Anna D'Angelillo
Raffaella Avellino
Stefano Messina
Nicola Corcione
Paolo Ferraro
P2860cites workVascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationQ22004269
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Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitorsQ28236317
TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathwayQ28580836
RGD and other recognition sequences for integrinsQ29616331
Signalling pathways of the TNF superfamily: a double-edged swordQ29616428
VEGF receptor signalling - in control of vascular functionQ29617256
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
Requirement of vascular integrin alpha v beta 3 for angiogenesisQ29619681
PI3K inhibitors for cancer treatment: where do we stand?Q34921551
Integrin αIIbβ3: from discovery to efficacious therapeutic targetQ37011736
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.Q37073648
Abciximab, eptifibatide, and tirofiban exhibit dose-dependent potencies to dissolve platelet aggregatesQ40661372
RGD peptides induce apoptosis by direct caspase-3 activation.Q40971438
Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerizationQ42612916
The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.Q42956330
Increased concentrations of tirofiban in blood and their correlation with inhibition of platelet aggregation after greater bolus doses of tirofibanQ44301237
In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosionQ44899711
Tirofiban induces VEGF production and stimulates migration and proliferation of endothelial cells.Q53056524
Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients.Q53536244
Atorvastatin sensitises vascular smooth muscle cells, but not endothelial cells, to TNF-α-induced cell death.Q54475719
Effect of anti-tumor necrosis factor-α polyclonal antibody on restenosis after balloon angioplasty in a rabbit atherosclerotic modelQ56944543
Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activationQ73462995
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamiliesQ79370601
P304page(s)67-74
P577publication date2015-12-15
P1433published inVascular PharmacologyQ7916446
P1476titleTirofiban counteracts endothelial cell apoptosis through the VEGF/VEGFR2/pAkt axis.
P478volume80

Reverse relations

cites work (P2860)
Q93140384Astragaloside IV inhibits oxidized low‑density lipoprotein‑induced endothelial damage via upregulation of miR‑140‑3p
Q33842838Novel small peptides derived from VEGF125-136: potential drugs for radioactive diagnosis and therapy in A549 tumor-bearing nude mice
Q37412613Platelet Integrin αIIbβ3 Inhibitor Rescues Progression of Apoptosis in Human Platelets
Q90470411The splicing FK506-binding protein-51 isoform plays a role in glioblastoma resistance through programmed cell death ligand-1 expression regulation

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