| scholarly article | Q13442814 |
| P356 | DOI | 10.1177/1947601910382899 |
| P953 | full work available at URL | https://doi.org/10.1177/1947601910382899 |
| https://europepmc.org/articles/PMC2994581 | ||
| https://europepmc.org/articles/PMC2994581?pdf=render | ||
| https://journals.sagepub.com/doi/pdf/10.1177/1947601910382899 | ||
| P932 | PMC publication ID | 2994581 |
| P698 | PubMed publication ID | 21127736 |
| P5875 | ResearchGate publication ID | 49654636 |
| P2093 | author name string | Jennifer Lee | |
| Pengbo Zhou | |||
| P2860 | cites work | The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 |
| Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells | Q22010574 | ||
| AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 | Q22254000 | ||
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
| Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors | Q24291157 | ||
| UV-damaged DNA-binding Proteins Are Targets of CUL-4A-mediated Ubiquitination and Degradation | Q24291831 | ||
| A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP) | Q24293710 | ||
| The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance | Q24293991 | ||
| SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor | Q24297139 | ||
| HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase | Q24297940 | ||
| SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response | Q24298620 | ||
| Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus | Q24300692 | ||
| The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage | Q24301297 | ||
| Identification of mutations in CUL7 in 3-M syndrome | Q34448386 | ||
| Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. | Q34503453 | ||
| Inflammation, a key event in cancer development | Q34512066 | ||
| The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. | Q34517945 | ||
| A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins | Q34528552 | ||
| Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation | Q34592792 | ||
| Proteasome inhibitors in the treatment of multiple myeloma | Q34611676 | ||
| DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase | Q34641190 | ||
| The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor | Q34647751 | ||
| CUL7 is a novel antiapoptotic oncogene | Q34702306 | ||
| DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases | Q35106169 | ||
| SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection | Q35613215 | ||
| The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). | Q35805056 | ||
| Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization | Q35857019 | ||
| Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor | Q36098917 | ||
| Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21 CIP1/WAF1 and cyclin D proteins | Q36310068 | ||
| A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1 | Q24301361 | ||
| Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery | Q24302241 | ||
| Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase | Q24304123 | ||
| CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation | Q24306802 | ||
| Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL | Q24311838 | ||
| PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex | Q24312855 | ||
| Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases | Q24313433 | ||
| Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation | Q24314520 | ||
| The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation | Q24315972 | ||
| WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase | Q24316117 | ||
| cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family | Q24336422 | ||
| Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7 | Q24337643 | ||
| Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase | Q24529056 | ||
| The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. | Q24544148 | ||
| Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction | Q24602385 | ||
| The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro | Q24608829 | ||
| Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB | Q24634406 | ||
| Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice | Q24642008 | ||
| Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation | Q24651352 | ||
| Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy | Q24652502 | ||
| SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation | Q24653723 | ||
| Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex | Q24670129 | ||
| DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest | Q24671784 | ||
| Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis | Q24680360 | ||
| Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle | Q24680705 | ||
| A protein knockdown strategy to study the function of beta-catenin in tumorigenesis | Q24805040 | ||
| Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ | Q27659474 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| Function and regulation of cullin-RING ubiquitin ligases | Q28131707 | ||
| SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 | Q28137860 | ||
| Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts | Q28138471 | ||
| Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha | Q28143121 | ||
| Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo | Q28177348 | ||
| Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage | Q28182301 | ||
| Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | Q28187304 | ||
| Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells | Q28201183 | ||
| Human claspin is required for replication checkpoint control | Q28206333 | ||
| Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex | Q28210666 | ||
| Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint | Q28212584 | ||
| Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase | Q28215069 | ||
| TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas | Q28218999 | ||
| Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage | Q28238604 | ||
| The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling | Q28240232 | ||
| Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase | Q28240243 | ||
| Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress | Q28255529 | ||
| Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery | Q28260190 | ||
| Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation | Q28284798 | ||
| CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation | Q28290857 | ||
| Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes | Q28292606 | ||
| Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1 | Q28301467 | ||
| betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis | Q28306984 | ||
| Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 | Q28382823 | ||
| REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase | Q28390295 | ||
| Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer | Q28469051 | ||
| Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E | Q28504517 | ||
| Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene | Q28506095 | ||
| Constitutive turnover of cyclin E by Cul3 maintains quiescence | Q28506695 | ||
| Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication | Q28507216 | ||
| Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis | Q28508088 | ||
| CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis | Q28508809 | ||
| Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans | Q47069321 | ||
| CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans | Q47069420 | ||
| A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. | Q47071852 | ||
| Skp2-mediated degradation of p27 regulates progression into mitosis | Q47640200 | ||
| Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p | Q47847570 | ||
| Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice | Q52591074 | ||
| Comparative genomic hybridization of squamous cell carcinoma of the esophagus: the possible involvement of the DPI gene in the 13q34 amplicon | Q53425309 | ||
| The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling | Q53545883 | ||
| Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability. | Q53572786 | ||
| Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation | Q53609401 | ||
| BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase | Q53633362 | ||
| Genetic Alterations in Childhood Medulloblastoma Analyzed by Comparative Genomic Hybridization | Q58183532 | ||
| Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E | Q58236966 | ||
| Overexpression of the human homologue for Caenorhabditis elegans cul-4 gene is associated with poor outcome in node-negative breast cancer | Q59616824 | ||
| Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins | Q73074519 | ||
| PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2) | Q73617626 | ||
| Adrenocortical carcinoma is characterized by a high frequency of chromosomal gains and high-level amplifications | Q73821482 | ||
| Somatic mutations of the beta-TrCP gene in gastric cancer | Q79763034 | ||
| Stabilization of prolactin receptor in breast cancer cells | Q81461032 | ||
| Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma | Q28589317 | ||
| Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase | Q28617041 | ||
| Cullin 4A associates with the UV-damaged DNA-binding protein DDB | Q28619483 | ||
| Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex | Q29041391 | ||
| Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway | Q29547371 | ||
| The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 | Q29547773 | ||
| FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation | Q29616127 | ||
| The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase | Q29616502 | ||
| Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation | Q29618051 | ||
| NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development | Q29620011 | ||
| EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors | Q33261811 | ||
| Down-regulation of the interferon signaling pathway in T lymphocytes from patients with metastatic melanoma. | Q33284046 | ||
| HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase | Q33290831 | ||
| The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4. | Q33292338 | ||
| Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes. | Q33627191 | ||
| Exploring the functional complexity of cellular proteins by protein knockout | Q33715456 | ||
| Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation | Q33755125 | ||
| Nedd8 on cullin: building an expressway to protein destruction. | Q33976667 | ||
| The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells | Q34012408 | ||
| Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation | Q34083015 | ||
| CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein | Q34275804 | ||
| Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage | Q34353149 | ||
| UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. | Q34417183 | ||
| Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. | Q36660357 | ||
| The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing | Q36898085 | ||
| Skp2 regulates G2/M progression in a p53-dependent manner | Q36954187 | ||
| Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer | Q37002726 | ||
| Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein | Q37073031 | ||
| Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer | Q37080006 | ||
| Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein | Q37240247 | ||
| Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism | Q37359358 | ||
| KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta | Q37406535 | ||
| NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer | Q37423465 | ||
| Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. | Q37446146 | ||
| Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase | Q37453413 | ||
| Adenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase | Q37459809 | ||
| New perspectives on APC control of cell fate and proliferation in colorectal cancer | Q37549825 | ||
| Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. | Q37574153 | ||
| Activation of the hedgehog-signaling pathway in human cancer and the clinical implications | Q37638143 | ||
| The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase | Q37729872 | ||
| Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation | Q38318841 | ||
| hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. | Q38353313 | ||
| The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system | Q39771199 | ||
| beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. | Q39792638 | ||
| Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. | Q39823935 | ||
| Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein | Q39832009 | ||
| SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis | Q39904875 | ||
| A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron. | Q39941210 | ||
| Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor. | Q40163119 | ||
| Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells. | Q40227584 | ||
| CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling | Q40266758 | ||
| Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation | Q40271317 | ||
| Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor | Q40520820 | ||
| Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions | Q41436188 | ||
| Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation. | Q41731658 | ||
| Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase | Q42631679 | ||
| Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation | Q42745906 | ||
| Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition | Q42819481 | ||
| Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. | Q44691496 | ||
| A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size | Q45118851 | ||
| Overexpression of human beta TrCP1 deleted of its F box induces tumorigenesis in transgenic mice | Q45286163 | ||
| Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells | Q45309132 | ||
| Abnormalities of the APC/beta-catenin pathway in endometrial cancer | Q45345268 | ||
| The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers | Q46612442 | ||
| CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans | Q47068715 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ubiquitin | Q407111 |
| cul-3 | Q29675796 | ||
| P304 | page(s) | 690-699 | |
| P577 | publication date | 2010-07-01 | |
| P1433 | published in | Genes & Cancer | Q26842471 |
| P1476 | title | Cullins and cancer | |
| Cullins and Cancer | |||
| P478 | volume | 1 |
| Q27936513 | A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. |
| Q34043935 | Accelerated hepatocellular carcinoma development in CUL4B transgenic mice |
| Q27027816 | Building and remodelling Cullin-RING E3 ubiquitin ligases |
| Q39212145 | CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line |
| Q39134142 | CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells |
| Q30433428 | CRL4Cdt2: master coordinator of cell cycle progression and genome stability |
| Q34051772 | Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa |
| Q28606437 | Comprehensive assessment of cancer missense mutation clustering in protein structures |
| Q30577461 | Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation |
| Q45931257 | Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. |
| Q26822657 | Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms |
| Q38059746 | Cullin-RING Ligases as Attractive Anti-cancer Targets |
| Q37343015 | Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. |
| Q52348724 | Dishevelled: A masterful conductor of complex Wnt signals. |
| Q39031671 | E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation |
| Q39152964 | Effects of the NEDD8-activating enzyme inhibitor MLN4924 on lytic reactivation of Kaposi's sarcoma-associated herpesvirus |
| Q28262931 | Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis |
| Q51699150 | Expression of CUL1 correlates with tumour-grade and recurrence in urothelial carcinoma |
| Q38058483 | Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase |
| Q27027897 | Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases |
| Q36387588 | It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53 |
| Q90581968 | Leucine-rich repeat and sterile alpha motif containing 1 promotes the oncogenic growth of human hepatocellular carcinoma cells |
| Q39531701 | Mutational analysis of VACM-1/cul5 exons in cancer cell lines |
| Q39181880 | Network-based identification of key proteins involved in apoptosis and cell cycle regulation. |
| Q30410498 | Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924 |
| Q39451819 | Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924. |
| Q61795911 | RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas |
| Q26827548 | Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic |
| Q36152200 | Regulation of the Abundance of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2 |
| Q92532060 | Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation |
| Q34043821 | Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications |
| Q36293814 | Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents |
| Q26866185 | Targeting the ubiquitin pathway for cancer treatment |
| Q90092804 | The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer |
| Q37354000 | The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies |
| Q101140357 | The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer |
| Q38608745 | The role of cullin proteins in gastric cancer |
| Q33802187 | The role of cullin4B in human cancers |
| Q34035063 | The role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1. |
| Q38112497 | The role of ubiquitin modification in the regulation of p53 |
| Q98564796 | The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes |
| Q33787405 | Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma |
| Q35137658 | β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells. |
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