Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

scientific article

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2010.01.029
P3181OpenCitations bibliographic resource ID3098174
P932PMC publication ID2828953
P698PubMed publication ID20178741
P5875ResearchGate publication ID41547820

P50authorHediye Erdjument-BromageQ25910537
Wei LiQ42789793
Ryohei IshiiQ55270467
Paul TempstQ25912123
P2093author name stringGaia Schiavon
Jonathan Cooper
Lu Zhou
Marco Giovannini
Pengbo Zhou
Filippo G Giancotti
C Oliver Hanemann
Stephen B Long
Liru You
Angela Pepe-Caprio
P2860cites workTumorigenic transformation by CPI-17 through inhibition of a merlin phosphataseQ24298753
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damageQ24301297
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1Q24301361
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationQ24307387
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligaseQ24321736
TEAD mediates YAP-dependent gene induction and growth controlQ24336045
Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycleQ24680705
Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortexQ37432747
Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-LQ37709703
Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannomaQ40075297
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.Q40077047
Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.Q40284714
Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin.Q40484684
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localizationQ40758119
Functional analysis of neurofibromatosis 2 (NF2) missense mutationsQ40793131
An alternative domain determines nuclear localization in multifunctional protein 4.1.Q41035102
Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cellsQ41740694
Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15.Q42810615
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.Q42823880
Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.Q54785852
Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cellsQ73424194
Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findingsQ80287223
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domainQ27637088
Wnt/beta-catenin signaling in development and diseaseQ27860784
p21-activated kinase links Rac/Cdc42 signaling to merlinQ28207198
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradationQ28272241
Membrane organization and tumorigenesis--the NF2 tumor suppressor, MerlinQ28275474
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growthQ28282803
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesisQ28508809
NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctionsQ28511556
Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1Q28513718
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesQ29547700
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domainQ29614381
Elucidation of a universal size-control mechanism in Drosophila and mammalsQ29618935
ERM proteins and merlin: integrators at the cell cortexQ29619893
Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane rufflingQ30411760
Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signalingQ30437229
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membraneQ30443407
Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysisQ31943093
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosisQ34474913
Delineation of a Fat tumor suppressor pathwayQ34566699
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligaseQ34641190
Isolation and mass spectrometry of transcription factor complexesQ34675839
Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic developmentQ34793207
Contact-dependent inhibition of EGFR signaling by Nf2/MerlinQ36118464
Ubiquitin proteasome system (UPS): what can chromatin do for you?Q36741709
Hippo signaling in organ size controlQ36793377
Shedding light on Merlin's wizardryQ36795086
Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.Q36878513
Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progressionQ36909853
NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growthQ37275182
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectneurofibromin 2Q410233
DDB1 and CUL4 associated factor 1Q21112163
P304page(s)477-90
P577publication date2010-02-19
P1433published inCellQ655814
P1476titleMerlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
P478volume140

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