Essential signaling in NF2 loss-related tumours: the therapeutic potential of CRL4DCAF1 and mTOR combined inhibition

scientific article published in October 2017

Essential signaling in NF2 loss-related tumours: the therapeutic potential of CRL4DCAF1 and mTOR combined inhibition is …
instance of (P31):
editorialQ871232
scholarly articleQ13442814

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P356DOI10.21037/JTD.2017.09.34
P932PMC publication ID5723899
P698PubMed publication ID29268334

P50authorHelena J Janse van RensburgQ87350758
P2093author name stringXiaolong Yang
P2860cites workMerlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleusQ24300692
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleusQ24300770
Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cellsQ28541763
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosisQ30357776
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2Q30387415
Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signalingQ30437229
Treatment of patients with advanced neurofibromatosis type 2 with novel molecularly targeted therapies: from bench to bedsideQ30458310
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammalsQ34077795
Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thoughtQ34392256
Role of Merlin/NF2 inactivation in tumor biologyQ36189820
NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growthQ37275182
Molecular insights into NF2/Merlin tumor suppressor functionQ38204110
Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo IndependentQ38784652
Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin.Q40484684
Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15.Q42810615
The neurofibromatosis type 2 gene is inactivated in schwannomasQ43555539
Compensative shuttling of merlin to phosphorylation on serine 518 in vestibular schwannomaQ46909683
The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of MerlinQ47972634
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressorQ48129277
Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis.Q53316010
Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomasQ58862180
Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancerQ72610940
P433issue10
P304page(s)3533-3536
P577publication date2017-10-01
P1433published inJournal of thoracic diseaseQ26841814
P1476titleEssential signaling in NF2 loss-related tumours: the therapeutic potential of CRL4DCAF1 and mTOR combined inhibition
P478volume9

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