Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

scientific article published in Nature

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1005563195
P356DOI10.1038/35003228
P698PubMed publication ID10646608

P50authorJosef PenningerQ1674391
Pamela OhashiQ56891473
P2093author name stringY Y Kong
T Sasaki
A Wakeham
J Le
I Sarosi
H Nishina
D Bouchard
K Bachmaier
S Lipkowitz
C Krawczyk
S Mariathasan
I Kozieradzki
A Itie
A Oliveira-dos-Santos
P2860cites workChronic inflammation caused by lymphotoxin is lymphoid neogenesisQ36366337
Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissueQ36404280
Blockade of the CD28 co-stimulatory pathway: a means to induce toleranceQ40396698
Cbl-b regulates the CD28 dependence of T-cell activation.Q40904107
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptorQ57185397
Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cellsQ58991849
Binding of T cell receptor to major histocompatibility complex class II-peptide complexes at the single-cell level results in the induction of antigen unresponsiveness (anergy)Q67589692
Primate evolution--in and out of AfricaQ95780651
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulationQ22008757
B lymphocytes express and lose syndecan at specific stages of differentiationQ24596510
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clonesQ28209894
Differential T cell costimulatory requirements in CD28-deficient miceQ28590647
Adaptors and molecular scaffolds in immune cell signalingQ28610104
The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinaseQ30193228
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.Q33560835
Altered thymic positive selection and intracellular signals in Cbl-deficient miceQ33596728
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceQ33776192
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.Q34449405
Positive versus negative signaling by lymphocyte antigen receptorsQ34468852
Functional management of an antiviral cytotoxic T-cell responseQ35889447
P433issue6766
P407language of work or nameEnglishQ1860
P304page(s)211-216
P577publication date2000-01-01
P1433published inNatureQ180445
P1476titleNegative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
P478volume403

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cites work (P2860)
Q34745654A Variable CD3+ T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat
Q37473160A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity
Q35063827A model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathway
Q36370638A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase
Q37588247A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.
Q33951432A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.
Q36079891AIRE and APECED: molecular insights into an autoimmune disease
Q30427703ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation
Q35664087Ablation of Cbl-b provides protection against transplanted and spontaneous tumors
Q34162136Abrogating Cbl-b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice
Q34517906Activation and inhibition of lymphocytes by costimulation
Q33898956Adapter proteins in lymphocyte antigen-receptor signaling
Q34282320Adapters in lymphocyte signalling
Q34044528Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase
Q47936492Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
Q34409836Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model
Q28078650Advantages of Extracellular Ubiquitin in Modulation of Immune Responses
Q36421662Alpha-MSH regulates protein ubiquitination in T cells
Q37370498Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus
Q91322503An RNA toolbox for cancer immunotherapy
Q41547133An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells
Q33746412Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b.
Q82786536Animal Models of Inflammatory Bowel Disease
Q34263452Antigen decoding by T lymphocytes: from synapses to fate determination
Q33937471Antigen-specific regulation of T cell-mediated cytokine production
Q34538693Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase
Q28068981Aptamers: A New Technological Platform in Cancer Immunotherapy
Q34120426Autoimmune thyroid disease: new models of cell death in autoimmunity
Q27676126Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
Q34405560Beyond the RING: CBL proteins as multivalent adapters
Q26744624Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression
Q54471021CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing
Q40588827CBLB ubiquitin ligase: a major regulator of antifungal immunity
Q45209871CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.
Q39407691CD14 gene silencing alters the microRNA expression profile of RAW264.7 cells stimulated by Brucella melitensis infection.
Q57289668CD28 Signaling via VAV/SLP-76 Adaptors
Q42169398CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation
Q40386654CD3ε recruits Numb to promote TCR degradation
Q24670063CD4+CD28- costimulation-independent T cells in multiple sclerosis
Q42552884CD43 regulates the threshold for T cell activation by targeting Cbl functions
Q37421679CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells.
Q60305294CD5, an Undercover Regulator of TCR Signaling
Q42586718CIMT 2014: Next waves in cancer immunotherapy--report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany
Q90482319CIMT 2019: report on the 17th Annual Meeting of the Association for Cancer Immunotherapy
Q24304461CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases
Q34611954CTLA-4 negative signaling via lipid rafts: A new perspective
Q24310048Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Q37003275Casitas B-lineage lymphoma b inhibits antigen recognition and slows cell cycle progression at late times during CD4+ T cell clonal expansion
Q77689842Cbl and Cbl-b in T-cell regulation
Q37283549Cbl- and Nedd4-family ubiquitin ligases: balancing tolerance and immunity
Q36138338Cbl-3-deficient mice exhibit normal epithelial development
Q37607147Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation
Q36300645Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma
Q37731713Cbl-b and itch: key regulators of peripheral T-cell tolerance
Q81543211Cbl-b differentially regulates activation-induced apoptosis in T helper 1 and T helper 2 cells
Q37748608Cbl-b in T-cell activation
Q40531841Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b
Q28585061Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells
Q33558284Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation
Q50958644Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
Q36370786Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.
Q24673177Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells
Q39736375Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation
Q34367640Cbl-b regulates airway mucosal tolerance to aeroallergen
Q40904107Cbl-b regulates the CD28 dependence of T-cell activation.
Q30168616Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.
Q35572346Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720.
Q33948376Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex
Q35735738Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity
Q34474505Cbl-c Ubiquitin Ligase Activity Is Increased via the Interaction of Its RING Finger Domain with a LIM Domain of the Paxillin Homolog, Hic 5
Q24301400Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation
Q43578123Cbl-mediated ubiquitinylation and negative regulation of Vav.
Q34205572Cbl: many adaptations to regulate protein tyrosine kinases
Q28573498Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
Q41091768Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition
Q38112644Cbl‐family proteins as regulators of cytoskeleton‐dependent phenomena
Q38380126Cell regulation by phosphotyrosine-targeted ubiquitin ligases
Q28771482Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation
Q34192425Comparative genomic organization of the cbl genes
Q34009660Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?
Q46736652Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis
Q35940280Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b
Q43077500Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection
Q28587056DLGH1 is a negative regulator of T-lymphocyte proliferation
Q34326683DOK3 Negatively Regulates LPS Responses and Endotoxin Tolerance
Q34568402Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses
Q24336767Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling
Q90354863Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance
Q42485920Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity.
Q28387136Does antigen masking by ubiquitin chains protect from the development of autoimmune diseases?
Q36585041Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease?
Q37473165Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease
Q28471948Drosophila cbl is essential for control of cell death and cell differentiation during eye development
Q51039411Dysregulation of anergy-related factors involved in regulatory T cells defects in Systemic Lupus Erythematosus patients: Rapamycin and Vitamin D efficacy in restoring regulatory T cells.
Q33551291E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.
Q35072559E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination
Q89207889E3 Ubiquitin Ligase c-cbl Inhibits Microglia Activation After Chronic Constriction Injury
Q35835790E3 ligases in T cell anergy--turning immune responses into tolerance
Q33953086E3 ubiquitin ligase Cbl-b in innate and adaptive immunity
Q50439358E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway
Q36070980E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity
Q37672304E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation
Q57369632E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
Q28750747E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance
Q24813057E3 ubiquitin ligases and their control of T cell autoreactivity
Q35873265E3 ubiquitin ligases as T cell anergy factors.
Q37588591E3 ubiquitin ligases in T-cell tolerance
Q90627972Early-onset inflammatory bowel disease as a model disease to identify key regulators of immune homeostasis mechanisms
Q43225888Engineering effective T-cell based antitumor immunity
Q37260135Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity
Q34596980Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice.
Q33577204Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Q28539113Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A
Q79173587Establishment and Characterization of the Komeda Diabetes-prone Rat as a Segregating Inbred Strain
Q38909897Exosomes from Dendritic Cells Loaded with Chaperone-Rich Cell Lysates Elicit a Potent T Cell Immune Response Against Intracranial Glioma in Mice
Q44389555Expression and function of Cbl-b in T cells from patients with systemic lupus erythematosus, and detection of the 2126 A/G Cblb gene polymorphism in the Mexican mestizo population.
Q36990608From T-cell activation signals to signaling control of anti-cancer immunity
Q41369044Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells
Q35604557GRAIL (Gene Related to Anergy in Lymphocytes) Regulates Cytoskeletal Reorganization through Ubiquitination and Degradation of Arp2/3 Subunit 5 and Coronin 1A
Q37809578GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness
Q28155998GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells
Q37710951Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms
Q35176426Genetic analysis of CD28 signaling
Q28591902Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice
Q26783085Genetically engineered mouse models for studying inflammatory bowel disease
Q36593309Genetics of SLE in mice
Q37839499Genome-wide association studies in multiple sclerosis: lessons and future prospects
Q47434293Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.
Q37172531HLA class II transgenic mice mimic human inflammatory diseases.
Q33708589Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.
Q28943483Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene
Q38356890Identification of embryonic pancreatic genes using Xenopus DNA microarrays
Q47774246Immune Regulation by Ubiquitin Tagging as Checkpoint Code.
Q38111096Immune modulation by genetic modification of dendritic cells with lentiviral vectors.
Q35193871Immune networks in animal models of inflammatory bowel disease
Q58570450Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch
Q36328809Immunity by ubiquitylation: a reversible process of modification
Q37864698Immunological perspective of self versus tumor antigens: insights from the RIP-gp model.
Q30680139Immunopathogenesis of the multiple sclerosis lesion
Q36371686Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice
Q51960672Impaired T-cell development in the absence of Vav1 and Itk.
Q82468648Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression
Q35015130Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo models
Q40610011Inhibition of CBLB protects from lethal Candida albicans sepsis
Q37677433Interruption of OX40L signaling prevents costimulation blockade-resistant allograft rejection
Q39272758Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity
Q35119897Intrinsic T Cell Defects in Systemic Autoimmunity
Q36608215Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy mice
Q41920687K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling
Q54245255K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.
Q34572115Knockout mice: a paradigm shift in modern immunology
Q36252532Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b
Q34111708Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy
Q37230559Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia
Q33912823Lymphocyte signaling: Cbl sets the threshold for autoimmunity
Q34091330Lymphocytes with a complex: adapter proteins in antigen receptor signaling
Q47757131Lys63-polyubiquitination by the E3 ligase casitas B-lineage lymphoma-b (Cbl-b) modulates peripheral regulatory T cell tolerance in patients with systemic lupus erythematosus.
Q38040302MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.
Q35119907Major Peptide Autoepitopes for Nucleosome‐Centered T and B Cell Interaction in Human and Murine Lupus
Q34987286Making and breaking tolerance.
Q35045888Many paths lead to lupus.
Q54256455Mechanisms of Tolerance Induction by Dendritic Cells In Vivo
Q28190356Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome
Q26852975MicroRNA regulation of lymphocyte tolerance and autoimmunity
Q37696126MicroRNA-891b is an independent prognostic factor of pancreatic cancer by targeting Cbl-b to suppress the growth of pancreatic cancer cells
Q38393275Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.
Q37465464Modulation of peripheral B cell tolerance by CD72 in a murine model
Q41536641Modulation of the spleen transcriptome in domestic turkey (Meleagris gallopavo) in response to aflatoxin B1 and probiotics
Q37049512Molecular and cellular mechanisms of photocarcinogenesis
Q34228160Molecular controls of antigen receptor clustering and autoimmunity
Q36870857Molecular mechanisms of CD4+ T-cell anergy
Q38098621Molecular mechanisms of T-cell anergy
Q33753720Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy
Q37864696Molecular mechanisms of T-cell tolerance.
Q35463260Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment
Q36466372Molecular regulation of T-cell anergy
Q34262298Molecular underpinning of B-cell anergy
Q28307750Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders
Q54642331Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling
Q36622748NFAT transcription factors in control of peripheral T cell tolerance.
Q33784244Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression
Q36839507Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2.
Q24632761Nedd4 controls animal growth by regulating IGF-1 signaling
Q34236595Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.
Q44405179Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.
Q35145782Negative regulation of TCR signaling and T-cell activation by selective protein degradation
Q44808755New autoimmune genes and the pathogenesis of type 1 diabetes
Q28608965New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
Q37899120Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
Q34306829Notch Ligand Delta-Like 4 Regulates Development and Pathogenesis of Allergic Airway Responses by Modulating IL-2 Production and Th2 Immunity
Q35549999Notch signaling in the immune system.
Q87402780Novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation
Q35899482Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation.
Q40854918On the Mechanism of T cell receptor down-modulation and its physiological significance.
Q42160561Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins
Q33753888Organization of proximal signal initiation at the TCR:CD3 complex
Q92101831Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells
Q28242808PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells
Q39207130PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal
Q40062424PD1 signal transduction pathways in T cells.
Q35181798Phosphoinositide 3-kinase signalling--which way to target?
Q33656136Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance
Q29620319Points of control in inflammation
Q51039264Polymorphic variation in the CBLB gene in human type 1 diabetes
Q34572179Positive and negative regulation of T-cell activation by adaptor proteins
Q38624562Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation.
Q36382352Progress in multiple sclerosis genetics
Q36177042Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation
Q26852269Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases
Q34088521Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.
Q26853207RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
Q37155467Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl
Q33588711Re-adapting T cells for cancer therapy: from mouse models to clinical trials
Q38711461Receptor signaling in immune cell development and function
Q35126405Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes
Q50534081Redirection to the bone marrow improves T cell persistence and antitumor functions.
Q46367310Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels
Q36508910Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins
Q57817463Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b
Q34987659Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications
Q37256999Regulation of T-cell responses by PTEN
Q39029996Regulation of TGF-β Family Signaling by Inhibitory Smads.
Q28587191Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2
Q36228270Regulation of peripheral T cell activation by calreticulin
Q40723397Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase
Q35084280Regulation of thymocyte development: only the meek survive
Q37412624Regulatory T cells overturned: the effectors fight back
Q39188794Relationship between CD4 Regulatory T Cells and Anergy In Vivo
Q21285001Releasing the Brake: Targeting Cbl-b to Enhance Lymphocyte Effector Functions
Q38363901Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation
Q36922987Role of phosphoinositide 3-kinase signaling in autoimmunity
Q33781079Roles of E3 ubiquitin ligases in cell adhesion and migration
Q35571851Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.
Q53667349Selective inhibition of Fcepsilon RI-mediated mast cell activation by a truncated variant of Cbl-b related to the rat model of type 1 diabetes mellitus
Q34187562Sin: good or bad? A T lymphocyte perspective
Q30496974Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization
Q34632056Spinning molecular immunology into successful immunotherapy
Q36229277Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells
Q46124218Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex
Q38721532Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.
Q33745662Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase
Q37087575T cell Receptor Signal Transduction in T lymphocytes
Q24658051T cell activation
Q36986111T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells
Q36369516T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase
Q37173926T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber
Q37783748T follicular helper cells during immunity and tolerance.
Q34567937T lymphocyte activation--an inside overview.
Q38103582T-Cell Tolerance in Cancer
Q35624722T-cell anergy: from phenotype to genotype and back
Q39150603T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation
Q36498083T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b
Q34093298T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency
Q24646289T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain
Q34716347T-cell signalling and autoimmunity: molecular mechanisms of disease
Q35998853T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens
Q57184989TCR affinity and negative regulation limit autoimmunity
Q80143450TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
Q37155730Targeting CBLB as a potential therapeutic approach for disseminated candidiasis
Q28277251The Cbl interactome and its functions
Q33357894The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Q33802637The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells
Q36791340The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance
Q24320362The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination
Q34299184The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival
Q28511124The MAGUK family protein CARD11 is essential for lymphocyte activation
Q35038302The autoantibody repertoire: searching for order
Q33958592The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.
Q45065835The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity
Q57090272The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia
Q48540784The reverse stop-signal model for CTLA4 function
Q39782506The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells
Q34769671The role of the e3 ligase cbl-B in murine dendritic cells.
Q38124036The role of ubiquitin ligases in the control of organ specific autoimmunity
Q42169339The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport
Q37593731The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state
Q41189915The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation.
Q40165041The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes.
Q37527221The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility
Q36453343The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.
Q37419923The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface
Q26781243Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity
Q35107814Therapeutic administration of the chemokine CXCL1/KC abrogates autoimmune inflammatory heart disease
Q33785953Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease
Q33979948Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
Q36453359Transcriptional basis of lymphocyte tolerance.
Q34135663Transcriptional mechanisms underlying lymphocyte tolerance.
Q36409007Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo
Q35155283Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells
Q28189981Two isoforms of otubain 1 regulate T cell anergy via GRAIL
Q92534916Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity
Q39317949Ubiquitin enzymes in the regulation of immune responses
Q26998711Ubiquitin in the immune system
Q26863525Ubiquitin-dependent regulation of Foxp3 and Treg function
Q37852608Ubiquitination in host immune response to human papillomavirus infection
Q38082222Ubiquitination signals critical to regulatory T cell development and function
Q33850593Ubiquitous points of control over regulatory T cells
Q26770849Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling
Q37424798Ubiquitylation in innate and adaptive immunity.
Q34732889Understanding Rho/Rac biology in T-cells using animal models
Q28189055Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
Q47275927Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets
Q36234273Utility of murine models for the study of spontaneous autoimmune type 1 diabetes
Q28943396Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis
Q51950654Vasopressin receptor 1a-mediated negative regulation of B cell receptor signaling
Q35579688Vav proteins, masters of the world of cytoskeleton organization.
Q34559351Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer
Q28610412Vav1: a key signal transducer downstream of the TCR
Q28206048Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte
Q37346002c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes
Q34157660c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation
Q36280423c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses
Q36787601c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells
Q33796333c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway
Q37732873cblb Gene Analysis in Japanese Type 1 Diabetes with Younger Age of Onset
Q34156303p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function
Q42932270β2 integrins inhibit TLR responses by regulating NF‐κB pathway and p38 MAPK activation
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