The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells

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The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0901243
P932PMC publication ID2857710
P698PubMed publication ID19801520
P5875ResearchGate publication ID224774922

P2093author name stringAdam J Adler
Adam T Hagymasi
Harry Z Qui
Marianne A Mihalyo
Marie-Clare St Rose
Robert B Clark
Suman Bandyopadhyay
P2860cites workCalcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsQ24310048
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunityQ24643886
Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T CellsQ24653129
Innate immune recognitionQ27860721
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Cblb is a major susceptibility gene for rat type 1 diabetes mellitusQ28573498
Tolerance, danger, and the extended familyQ29547532
The Fas death factorQ29620461
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivoQ30080006
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.Q30168616
In vivo cyclophosphamide and IL-2 treatment impedes self-antigen-induced effector CD4 cell tolerization: implications for adoptive immunotherapyQ33756565
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic miceQ45854348
Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunityQ46094710
Adjuvant effect of IL-12: conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivo.Q52032514
IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cellsQ52267043
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.Q55035366
CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive toleranceQ56903158
T cell tolerance by clonal elimination in the thymusQ56922465
Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral toleranceQ58882235
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-bQ59058408
T-cell apoptosis detected in situ during positive and negative selection in the thymusQ59087078
Distinct Requirements for Deletion versus Anergy during CD8 T Cell Peripheral Tolerance In VivoQ61140313
CD4+ T Cells Pass Through an Effector Phase During the Process of In Vivo Tolerance InductionQ61140374
Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferationQ68261487
In vivo CD4+ T cell tolerance induction versus priming is independent of the rate and number of cell divisionsQ73330334
Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletionQ73406538
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideQ73688337
CD4 cell priming and tolerization are differentially programmed by APCs upon initial engagementQ74145423
CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritisQ80455078
Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-alpha and IFN-gamma expression potentialsQ33756571
Steady state dendritic cells present parenchymal self-antigen and contribute to, but are not essential for, tolerization of naive and Th1 effector CD4 cellsQ33756646
Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigenQ33756662
T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expressionQ33756668
Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulationQ33756678
Effector CD4 cells are tolerized upon exposure to parenchymal self-antigenQ33791198
Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigenQ33791226
Regulatory T cells: key controllers of immunologic self-toleranceQ33941140
Transcriptional mechanisms underlying lymphocyte tolerance.Q34135663
In vivo activation of antigen-specific CD4 T cells.Q34178091
Immune responses against the myelin/oligodendrocyte glycoprotein in experimental autoimmune demyelinationQ34279716
In vivo instruction of suppressor commitment in naive T cellsQ34548023
T-cell signalling and autoimmunity: molecular mechanisms of diseaseQ34716347
Peripheral selection of the T cell repertoireQ34880495
T cell anergyQ35019694
The role of CD95 in the regulation of peripheral T-cell apoptosisQ35129712
E3 ubiquitin ligases as T cell anergy factors.Q35873265
Peripheral tolerance of CD8 T lymphocytesQ36076297
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivoQ36353340
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cellsQ36356623
Certified professionals: CD4(+)CD25(+) suppressor T cellsQ36369181
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanismQ36392973
CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting CellsQ36400881
Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular DestructionQ36401408
Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-bQ36773147
Casitas B-lineage lymphoma b inhibits antigen recognition and slows cell cycle progression at late times during CD4+ T cell clonal expansionQ37003275
New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprintingQ37506953
Egr-2 and Egr-3 are negative regulators of T cell activation.Q38327900
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.Q40110921
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivoQ40327455
Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigenQ40701079
Cbl-b regulates the CD28 dependence of T-cell activation.Q40904107
Maintenance of in vivo tolerance by persistence of antigenQ41828244
Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptorQ41902311
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune responseQ43986613
Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- miceQ44240372
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytesQ44851100
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.Q45179048
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)4975-4983
P577publication date2009-10-01
P1433published inJournal of ImmunologyQ3521441
P1476titleThe E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells
P478volume183

Reverse relations

cites work (P2860)
Q34162136Abrogating Cbl-b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice
Q33746412Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b.
Q47774246Immune Regulation by Ubiquitin Tagging as Checkpoint Code.
Q38124036The role of ubiquitin ligases in the control of organ specific autoimmunity

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