| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/82_2017_64 |
| P698 | PubMed publication ID | 28929193 |
| P50 | author | Yun-Cai Liu | Q58812903 |
| P2093 | author name string | Peng Zeng | |
| Runqing Yang | |||
| Jieyu Ma | |||
| P2860 | cites work | Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction | Q22001513 |
| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
| HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 | ||
| Linear ubiquitination prevents inflammation and regulates immune signalling | Q24298581 | ||
| SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis | Q24298626 | ||
| De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling | Q24299573 | ||
| A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7 | Q24300148 | ||
| T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20 | Q24307779 | ||
| The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice | Q24308721 | ||
| Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins | Q24310048 | ||
| The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling | Q24314649 | ||
| Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains | Q24316967 | ||
| Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1 | Q24336199 | ||
| Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling | Q24336767 | ||
| Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species | Q24338871 | ||
| The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation | Q24610637 | ||
| Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells | Q24615775 | ||
| Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice | Q24616207 | ||
| Control of regulatory T cell development by the transcription factor Foxp3 | Q27860489 | ||
| Foxp3 programs the development and function of CD4+CD25+ regulatory T cells | Q27860714 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases | Q28139237 | ||
| Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice | Q28140546 | ||
| Identification of the familial cylindromatosis tumour-suppressor gene | Q28145560 | ||
| Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. | Q36502902 | ||
| Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease. | Q36598807 | ||
| Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease | Q36649404 | ||
| Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b | Q36773147 | ||
| GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells | Q28155998 | ||
| The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination | Q28201717 | ||
| PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells | Q28242808 | ||
| The ubiquitin code | Q28265104 | ||
| A genomic and functional inventory of deubiquitinating enzymes | Q28284911 | ||
| The tumor suppressor CYLD controls the function of murine regulatory T cells | Q28505871 | ||
| Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase | Q28506124 | ||
| The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals | Q28506474 | ||
| Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation | Q28510102 | ||
| Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells | Q28585061 | ||
| B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice | Q28588121 | ||
| Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling | Q28588278 | ||
| Regulation of T cell development by the deubiquitinating enzyme CYLD | Q28588773 | ||
| Dependence of self-tolerance on TRAF6-directed development of thymic stroma | Q28590193 | ||
| The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 | Q28591890 | ||
| The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20 | Q28593201 | ||
| Mechanisms of peripheral tolerance to allergens | Q29027397 | ||
| Follicular helper CD4 T cells (TFH) | Q29615063 | ||
| The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses | Q29616349 | ||
| Regulatory T cells and immune tolerance | Q29616864 | ||
| CTLA-4 control over Foxp3+ regulatory T cell function | Q29619413 | ||
| Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. | Q30168616 | ||
| Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics | Q30524705 | ||
| IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway | Q33294682 | ||
| Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b. | Q33746412 | ||
| The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells | Q33802637 | ||
| Regulation of natural killer T-cell development by deubiquitinase CYLD | Q33878486 | ||
| TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. | Q33931833 | ||
| Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis | Q33966409 | ||
| Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells | Q33979948 | ||
| The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. | Q34041946 | ||
| The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. | Q34097297 | ||
| c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation | Q34157660 | ||
| Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes. | Q34159850 | ||
| Abrogating Cbl-b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice | Q34162136 | ||
| Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells | Q42510282 | ||
| TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation | Q42702792 | ||
| Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection | Q43077500 | ||
| Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice | Q44240372 | ||
| Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b. | Q44405179 | ||
| PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation | Q44764543 | ||
| Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha | Q44948359 | ||
| Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. | Q45179048 | ||
| TRAF6 directs commitment to regulatory T cells in thymocytes | Q45356807 | ||
| Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. | Q45718626 | ||
| Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination | Q46118529 | ||
| Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch | Q46802020 | ||
| ITCH deficiency protects from diet-induced obesity. | Q46809066 | ||
| A20 controls intestinal homeostasis through cell-specific activities | Q46832278 | ||
| Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies | Q47936492 | ||
| Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination. | Q48193515 | ||
| Regulatory T cells: recommendations to simplify the nomenclature. | Q48624465 | ||
| A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis | Q49050925 | ||
| The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. | Q49169701 | ||
| A20 and CYLD do not share significant overlapping functions during B cell development and activation. | Q50783685 | ||
| Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells. | Q50958644 | ||
| Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. | Q52545197 | ||
| MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. | Q54724272 | ||
| Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b | Q57184850 | ||
| TCR affinity and negative regulation limit autoimmunity | Q57184989 | ||
| Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b | Q59058408 | ||
| Foxp3-dependent programme of regulatory T-cell differentiation | Q59084714 | ||
| A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression | Q36933695 | ||
| Casitas B-lineage lymphoma b inhibits antigen recognition and slows cell cycle progression at late times during CD4+ T cell clonal expansion | Q37003275 | ||
| SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex | Q37033632 | ||
| Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway | Q37150447 | ||
| Vav1-phospholipase C-γ1 (Vav1-PLC-γ1) pathway initiated by T cell antigen receptor (TCRγδ) activation is required to overcome inhibition by ubiquitin ligase Cbl-b during γδT cell cytotoxicity | Q37168337 | ||
| Deubiquitylation and regulation of the immune response | Q37184075 | ||
| Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner | Q37233985 | ||
| Itch expression by Treg cells controls Th2 inflammatory responses. | Q37259247 | ||
| Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes | Q37336094 | ||
| Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1. | Q37394376 | ||
| The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility | Q37527221 | ||
| Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production | Q37554411 | ||
| A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. | Q37588247 | ||
| E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation | Q37672304 | ||
| The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. | Q37733779 | ||
| Deubiquitinases in cancer: new functions and therapeutic options. | Q37945451 | ||
| The ubiquitin system in immune regulation. | Q38245098 | ||
| Modulation of Immune Cell Functions by the E3 Ligase Cbl-b. | Q38393275 | ||
| The E3 ligase Itch in immune regulation and beyond. | Q38530613 | ||
| Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system | Q38530619 | ||
| Silencing the expression of Cbl-b enhances the immune activation of T lymphocytes against RM-1 prostate cancer cells in vitro. | Q38953896 | ||
| Deltex1 promotes protein kinase Cθ degradation and sustains Casitas B-lineage lymphoma expression. | Q38977477 | ||
| T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation | Q39150603 | ||
| Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis | Q39179203 | ||
| A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis | Q39464232 | ||
| Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions | Q39605573 | ||
| A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. | Q39843043 | ||
| Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance | Q40071336 | ||
| Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells | Q40140592 | ||
| Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo | Q40327455 | ||
| Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. | Q40334819 | ||
| SHARPIN controls the development of regulatory T cells | Q40771683 | ||
| Cbl-b regulates the CD28 dependence of T-cell activation. | Q40904107 | ||
| Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. | Q41096230 | ||
| Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. | Q41112588 | ||
| The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells | Q41560743 | ||
| Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD | Q41782395 | ||
| Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation | Q41791638 | ||
| Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition | Q41902497 | ||
| Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function | Q41904331 | ||
| K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling | Q41920687 | ||
| Interleukin-13 suppresses interleukin-10 via inhibiting A20 in peripheral B cells of patients with food allergy | Q42107095 | ||
| Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner | Q42474606 | ||
| Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model | Q34409836 | ||
| Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation | Q34468354 | ||
| A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response. | Q34473746 | ||
| Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change | Q34478754 | ||
| Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes | Q34512302 | ||
| The enemy within: keeping self-reactive T cells at bay in the periphery | Q34573771 | ||
| Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. | Q34590849 | ||
| GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype | Q34607035 | ||
| Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. | Q34655006 | ||
| The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells | Q34901817 | ||
| TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity | Q34994847 | ||
| A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity | Q34996919 | ||
| Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence | Q35064904 | ||
| E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination | Q35072559 | ||
| A20 is critical for the induction of Pam3CSK4-tolerance in monocytic THP-1 cells | Q35086715 | ||
| Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice | Q35099711 | ||
| ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. | Q35101189 | ||
| HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells | Q35102340 | ||
| Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling | Q35182251 | ||
| The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells | Q35562497 | ||
| The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis | Q35630131 | ||
| Ablation of Cbl-b provides protection against transplanted and spontaneous tumors | Q35664087 | ||
| E3 ligases in T cell anergy--turning immune responses into tolerance | Q35835790 | ||
| E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity. | Q35837701 | ||
| E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity | Q36070980 | ||
| Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. | Q36164605 | ||
| Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation | Q36177042 | ||
| Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells | Q36229277 | ||
| Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses | Q36229402 | ||
| Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa | Q36339991 | ||
| T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells | Q36402737 | ||
| Regulatory T cells, tumour immunity and immunotherapy | Q36430144 | ||
| Molecular regulation of T-cell anergy | Q36466372 | ||
| Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages | Q36474924 | ||
| T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b | Q36498083 | ||
| P304 | page(s) | 215-248 | |
| P577 | publication date | 2017-01-01 | |
| P1433 | published in | Current Topics in Microbiology and Immunology | Q15752446 |
| P1476 | title | Immune Regulation by Ubiquitin Tagging as Checkpoint Code | |
| P478 | volume | 410 |
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