PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation

scientific article published on 23 June 2009

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.2000046
P698PubMed publication ID19549985

P50authorThomas GruberQ64025622
Natascha Hermann-KleiterQ120598795
Günther GastlQ125249671
Friedrich FresserQ125251449
Josef PenningerQ1674391
P2093author name stringGottfried Baier
Rainer Schneider
Reinhard Hinterleitner
P433issue76
P921main subjectprotein ubiquitinationQ3547638
P304page(s)ra30
P577publication date2009-06-23
P1433published inScience SignalingQ7433604
P1476titlePKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation
P478volume2

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cites work (P2860)
Q35063827A model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathway
Q33855540Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses
Q34409836Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model
Q26744624Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression
Q42552884CD43 regulates the threshold for T cell activation by targeting Cbl functions
Q38038873Cbl proteins in platelet activation
Q37607147Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation
Q37748608Cbl-b in T-cell activation
Q36867563Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.
Q50958644Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
Q35572346Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720.
Q35735738Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity
Q41091768Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition
Q111442282Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells
Q90354863Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance
Q33953086E3 ubiquitin ligase Cbl-b in innate and adaptive immunity
Q37179037E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity
Q37672304E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation
Q47434293Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.
Q47774246Immune Regulation by Ubiquitin Tagging as Checkpoint Code.
Q90318660Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy
Q84599923Inhibiting the Inhibitor of the Inhibitor: Blocking PKC-θ to Enhance Regulatory T Cell Function
Q41975118Involvement of distinct PKC gene products in T cell functions
Q89229413Isoflurane decreases interleukin-2 production by increasing c-Cbl and Cbl-b expression in rat peripheral blood mononuclear cells
Q41118609Meeting report: Signal transduction meets systems biology
Q64083066Modulation of B cell activation threshold mediated by BCR/CD40 costimulation by targeting Cbl-b for ubiquitination
Q38393275Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.
Q36131918Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc
Q36451833Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.
Q34118353PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes
Q35552713PKCθ activation in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors is needed for stimulation of numerous important cellular signaling cascades
Q42321322PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton
Q36177042Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation
Q42819083Protein kinase C βII and δ/θ play critical roles in bone morphogenic protein-4-stimulated osteoblastic differentiation of MC3T3-E1 cells
Q54309549Protein kinase Cθ: the pleiotropic T-cell signalling intermediate.
Q42257149Regulating the Regulator: Phosphorylation of PKC θ in T Cells
Q57817463Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b
Q21285001Releasing the brake: targeting Cbl-b to enhance lymphocyte effector functions
Q33781079Roles of E3 ubiquitin ligases in cell adhesion and migration
Q27024068The Novel PKCθ from Benchtop to Clinic
Q36632900The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis
Q38835389Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function
Q37852608Ubiquitination in host immune response to human papillomavirus infection
Q37849576Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

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