E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity

scientific article published on 18 July 2016

E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20151932
P932PMC publication ID4986534
P698PubMed publication ID27432944

P50authorJin-Fu XuQ61161156
Xin LinQ85605179
Yahui GuoQ91303102
Tian-Ming LuoQ96199656
P2093author name stringXin-Ming Jia
Yuan-Ying Jiang
Xia Xu
Bing Tang
Ting-Ting Wang
Le-Le Zhu
Xue-Qiang Zhao
P2860cites workTyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulationQ22008757
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?Q24617857
Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responsesQ28115369
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunityQ28118774
cbl-b inhibits epidermal growth factor receptor signalingQ28139234
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunityQ28504584
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-bQ28506491
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicansQ28508646
Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responsesQ28513762
Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-bQ28577868
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.Q30168616
Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.Q30531717
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.Q33357894
Mincle is a long sought receptor for mycobacterial cord factorQ33590457
A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cellsQ33854830
E3 ubiquitin ligase Cbl-b in innate and adaptive immunityQ33953086
CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicansQ34074248
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin MincleQ34087974
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.Q34088521
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulationQ34157660
C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activationQ34396971
The role of the e3 ligase cbl-B in murine dendritic cells.Q34769671
Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.Q34977717
Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular trapsQ35557248
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responsesQ35630243
Signaling by myeloid C-type lectin receptors in immunity and homeostasisQ35779708
The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase.Q36122145
Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.Q36370786
Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infectionQ36492765
Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteinsQ36508910
The SYK tyrosine kinase: a crucial player in diverse biological functionsQ36662082
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lungQ37016835
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infectionQ37331568
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.Q37394376
Ubiquitylation in innate and adaptive immunity.Q37424798
CARD9 versus CARMA1 in innate and adaptive immunityQ37440232
ESCRT proteins and cell signallingQ37868733
Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.Q38393275
Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ.Q39114386
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complexQ39797161
Cbl-b regulates the CD28 dependence of T-cell activation.Q40904107
Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteriaQ41759445
Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in miceQ42826978
Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirusQ44013677
PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradationQ44764543
C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infectionQ44918036
Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptorQ44987474
The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor.Q51030807
Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal PathwayQ57385011
Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidityQ79912619
Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-BQ81317219
Proteolysis: from the lysosome to ubiquitin and the proteasomeQ81354981
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1555-1570
P577publication date2016-07-18
P1433published inJournal of Experimental MedicineQ3186912
P1476titleE3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity
P478volume213

Reverse relations

cites work (P2860)
Q88693847Antifungal Innate Immunity: A Perspective from the Last 10 Years
Q88182685C-type lectins in immunity and homeostasis
Q90579335CBLB Constrains Inactivated Vaccine-Induced CD8+ T Cell Responses and Immunity against Lethal Fungal Pneumonia
Q92969533Cellular and molecular mechanisms of antifungal innate immunity at epithelial barriers: The role of C-type lectin receptors
Q39123280Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors
Q92627518Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity
Q90001228Glutathione Reductase Promotes Fungal Clearance and Suppresses Inflammation during Systemic Candida albicans Infection in Mice
Q33752362Immunity against fungi
Q39201643Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance
Q40361934JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression
Q47334511Modulating Host Signaling Pathways to Promote Resistance to Infection by Candida albicans
Q52664258Pattern recognition receptors in fungal immunity.
Q64991646Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans.
Q96303597Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae
Q49956875Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity
Q83230893Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

Search more.