The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation.

scientific article published on 23 October 2015

The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1189/JLB.3A0315-135R
P698PubMed publication ID26497245

P50authorPeter SteinbergerQ40360267
Gregor HoermannQ50930011
Georg GreinerQ52788154
Franz RatzingerQ56844755
Ralf L J SchmidtQ86548623
P2093author name stringRodrig Marculescu
Winfried F Pickl
Klaus G Schmetterer
Nadine Witzeneder
Sabrina Jutz
Johanna Prodinger
Lisa J Loacker
P2860cites work3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survivalQ39611354
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Destabilization of peptide:MHC interaction induces IL-2 resistant anergy in diabetogenic T cellsQ41772561
Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletionQ43008746
Transforming growth factor beta 1 (TGF-beta1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ TregsQ43121941
Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.Q43950657
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Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression.Q44634043
Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.Q44807466
Concentrations of cyclosporin A and FK506 that inhibit IL-2 induction in human T cells do not affect TGF-beta1 biosynthesis, whereas higher doses of cyclosporin A trigger apoptosis and release of preformed TGF-beta1.Q45269848
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiationQ46487258
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Prevention of Allogeneic Fetal Rejection by Tryptophan CatabolismQ24336018
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolismQ24337667
IDO expression by dendritic cells: tolerance and tryptophan catabolismQ29614752
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed settingQ29618424
MYC on the Path to CancerQ29619979
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Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b.Q33746412
Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.Q34000160
The TOR kinases link nutrient sensing to cell growthQ34194195
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activationQ34242691
T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cellsQ34284626
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in miceQ34286263
Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.Q34427919
Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity.Q34675784
The effects of Cyclosporine A and azathioprine on human T cells activated by different costimulatory signalsQ35191057
mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.Q35611316
IDO and tolerance to tumorsQ35628246
3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosisQ36276917
Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.Q36376561
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolitesQ36376598
Distinct TCR signaling pathways drive proliferation and cytokine production in T cellsQ36625346
IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genesQ37153986
Abl tyrosine kinases in T-cell signalingQ37182419
The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematologyQ37331219
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcriptionQ37564002
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Metabolic checkpoints in activated T cellsQ38044664
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.Q38218127
P433issue4
P304page(s)583-594
P577publication date2015-10-23
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleThe tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation
P478volume99

Reverse relations

cites work (P2860)
Q37627829Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation.
Q92500840Identification and Characterization of a Novel pic Gene Cluster Responsible for Picolinic Acid Degradation in Alcaligenes faecalis JQ135
Q93082071Ironing out Macrophage Immunometabolism
Q50217787Metabolic Regulation of T Cell Immunity
Q87875813Prospective study of blood metabolites associated with colorectal cancer risk
Q47865416The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity
Q49194479The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
Q48272907The role of indoleamine-2,3-dioxygenase in normal and pathological pregnancies

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