E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance (scientific article (publication date: 29 September 2009))

The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane

Q42151552

Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK.

Q42159544

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

Q45179048

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells

Q47310168

Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells

Q51037372

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

Q58617364

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

Q58882241

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

Q59058408

The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis

Q79445145

Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells

Q80057973

TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis

Q80143450

Oral tolerance

Q80945963

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

Q24310048

Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy

Q24597077

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

Q28155998

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

Q28189981

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

Q28507088

Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

Q28590075

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

Q28609096

Selective function of PKC-theta in T cells

Q28647196

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells

Q33624770

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

Q33936032

Transcriptional mechanisms underlying lymphocyte tolerance.

Q34135663

Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking

Q34325683

MAP kinases in the immune response

Q34542231

Protein kinase C(theta) in T cell activation

Q34542294

The enemy within: keeping self-reactive T cells at bay in the periphery

Q34573771

GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype

Q34607035

T cell anergy

Q35019694

Protein kinase C-theta (PKCtheta): it's all about location, location, location.

Q35096674

Protein kinase C theta (PKCtheta): a key player in T cell life and death

Q36838094

Molecular mechanisms of CD4+ T-cell anergy

Q36870857

The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells

Q37013471

Differential requirement of PKC-theta in the development and function of natural regulatory T cells

Q37236962

p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells

Q39968515

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

T cell activation

Q14863969

P304

page(s)

16770-5

P577

publication date

2009-09-29

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance

P478

volume

106

Reverse relations

cites work (P2860)

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P819	ADS bibcode	2009PNAS..10616770K
P356	DOI	10.1073/PNAS.0908957106
P932	PMC publication ID	2757842
P698	PubMed publication ID	19805371
P5875	ResearchGate publication ID	26871547