Drosophila cbl is essential for control of cell death and cell differentiation during eye development

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Drosophila cbl is essential for control of cell death and cell differentiation during eye development is …
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scholarly articleQ13442814

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P819ADS bibcode2008PLoSO...3.1447W
P356DOI10.1371/JOURNAL.PONE.0001447
P932PMC publication ID2180199
P698PubMed publication ID18197257
P5875ResearchGate publication ID5654786

P2093author name stringAndreas Bergmann
Yuan Wang
Ying Li
Dongbin Xu
Ernst Hafen
Zhihong Chen
Christian Werz
P2860cites workThe Hallmarks of CancerQ221226
Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaicsQ52171416
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila.Q52177458
In Situ Activation Pattern of Drosophila EGF Receptor Pathway During DevelopmentQ52192958
Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathwayQ52207709
The emergence of order in the Drosophila pupal retinaQ52453111
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.Q52551521
Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activationQ52565560
Sprouty, an intracellular inhibitor of Ras signalingQ52569025
A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye.Q53668894
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-bQ59058408
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptorQ78069495
The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in DrosophilaQ36846541
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomasQ37252270
Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in DrosophilaQ37383561
The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptorQ39757659
Cbl-b regulates the CD28 dependence of T-cell activation.Q40904107
Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant DrosophilaQ40982035
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signalingQ40995001
Ubiquitous expression of sevenless: position-dependent specification of cell fateQ41260139
Ommatidial development in Drosophila eye disc fragmentsQ41381190
Giant lens, a gene involved in cell determination and axon guidance in the visual system of Drosophila melanogasterQ41528680
vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosisQ42003445
Notch activation of yan expression is antagonized by RTK/pointed signaling in the Drosophila eye.Q42673863
Development of the Drosophila retina, a neurocrystalline latticeQ43989421
Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye.Q44687983
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domainQ44689071
Regulation of Drosophila neural development by a putative secreted proteinQ44902624
A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye.Q45129152
The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retinaQ46042874
A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinaseQ46204426
Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migrationQ46626360
The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosisQ47069969
Ras promotes cell survival in Drosophila by downregulating hid expressionQ47070193
The head involution defective gene of Drosophila melanogaster functions in programmed cell deathQ47070937
The Drosophila gene torso encodes a putative receptor tyrosine kinaseQ47071829
D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesisQ47072323
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulationQ24336399
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomasQ24624849
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7Q28146026
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
The Cbl interactome and its functionsQ28277251
Epidermal growth factor receptor mutations in lung cancerQ29615474
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1Q29617290
Analysis of genetic mosaics in developing and adult Drosophila tissuesQ29617838
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradationQ29622825
A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivoQ30168862
D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites.Q30176514
Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.Q30176591
Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cblQ30193172
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceQ33776192
A screen for genes that function downstream of Ras1 during Drosophila eye development.Q33967357
Cbl: many adaptations to regulate protein tyrosine kinasesQ34205572
Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.Q34303458
Beyond the RING: CBL proteins as multivalent adaptersQ34405560
The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye.Q34439501
Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinasesQ35169572
Signal integration during development: insights from the Drosophila eye.Q35618173
Cbl-3-deficient mice exhibit normal epithelial developmentQ36138338
Negative regulation of PTK signalling by Cbl proteinsQ36194521
Signal transduction and the fate of the R7 photoreceptor in DrosophilaQ36471874
ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activityQ36820100
The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in DrosophilaQ36844137
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
DrosophilaQ312154
cell deathQ2383867
P304page(s)e1447
P577publication date2008-01-16
P1433published inPLOS OneQ564954
P1476titleDrosophila cbl is essential for control of cell death and cell differentiation during eye development
P478volume3

Reverse relations

cites work (P2860)
Q33528991CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases
Q33826264D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis
Q33929193Endocytic pathway is required for Drosophila Toll innate immune signaling
Q46578462Feedback regulation of RTK signaling in development.
Q37242772Genetic control of programmed cell death (apoptosis) in Drosophila
Q35989025Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms.
Q36699882Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor.
Q36197104Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.
Q36560463Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila
Q26852269Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases
Q36455731Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system
Q33838124Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development
Q33619834The role of ubiquitylation for the control of cell death in Drosophila

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