Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A

scientific article (publication date: 2014)

Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...987116K
P356DOI10.1371/JOURNAL.PONE.0087116
P932PMC publication ID3900716
P698PubMed publication ID24466333
P5875ResearchGate publication ID259920565

P2093author name stringStanley Lipkowitz
Stephen C Kales
Marion M Nau
Anand S Merchant
P2860cites workcbl-3: a new mammalian cbl family proteinQ22009959
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53Q22253350
Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradationQ24301400
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogeneQ24322680
LIM domain recognition of a tyrosine-containing tight turnQ24322821
Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.Q24533621
ret transforming gene encodes a fusion protein homologous to tyrosine kinasesQ24628687
The PDZ domain of the LIM protein enigma binds to beta-tropomyosinQ24648940
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisQ26853207
Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-bQ27646953
The LIM domain: regulation by associationQ28137861
cbl-b inhibits epidermal growth factor receptor signalingQ28139234
Genetics of Hirschsprung diseaseQ28139433
Characterization of the ret proto-oncogene products expressed in mouse L cellsQ28265050
The Cbl interactome and its functionsQ28277251
Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinaseQ28575205
Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradationQ28580654
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domainQ29614381
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1Q29617290
Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligaseQ33292370
Altered thymic positive selection and intracellular signals in Cbl-deficient miceQ33596728
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceQ33776192
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimizationQ33875853
Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complexQ33948376
Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell lineQ33981089
Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesisQ34080215
Comparative genomic organization of the cbl genesQ34192425
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in miceQ34360157
Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.Q34474505
Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approachQ34589458
Cbl-3-deficient mice exhibit normal epithelial developmentQ36138338
The rearranged during transfection/papillary thyroid carcinoma tyrosine kinase is an estrogen-dependent gene required for the growth of estrogen receptor positive breast cancer cellsQ36180128
Alternative splicing results in RET isoforms with distinct trafficking properties.Q36284502
EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteinsQ36508737
Specificity of LIM domain interactions with receptor tyrosine kinasesQ36802964
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transductionQ37352330
Inhibition of RET activated pathways: novel strategies for therapeutic intervention in human cancersQ38042995
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.Q39751877
The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancerQ39981895
A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancerQ40033636
Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.Q40100421
Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).Q40524623
Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-bQ40531841
Cbl-b regulates the CD28 dependence of T-cell activation.Q40904107
RET activation by germline MEN2A and MEN2B mutationsQ41260398
Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domainQ42812834
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-bQ59058408
The human CBL oncogeneQ70237241
Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2Q79354839
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)e87116
P577publication date2014-01-01
P1433published inPLOS OneQ564954
P1476titleEnigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A
P478volume9

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cites work (P2860)
Q64231562Afadin cooperates with Claudin-2 to promote breast cancer metastasis
Q27853152Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity
Q38631763Differential recruitment of E3-ubiquitin ligase complexes regulates RET isoform internalization
Q64086696Identification of Triple-Negative Breast Cancer Genes and a Novel High-Risk Breast Cancer Prediction Model Development Based on PPI Data and Support Vector Machines
Q46228906Pathologic significance of a novel oncoprotein in thyroid cancer progression
Q36560048RNF135, RING finger protein, promotes the proliferation of human glioblastoma cells in vivo and in vitro via the ERK pathway
Q38366765The RET oncogene in papillary thyroid carcinoma

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